PubMed,
Год журнала:
2024,
Номер
49(8), С. 1353 - 1362
Опубликована: Авг. 28, 2024
Renal
fibrosis
is
the
common
pathological
basis
for
progressive
development
of
chronic
kidney
disease
(CKD)
caused
by
various
etiologies.
It
characterized
persistent
deposition
extracellular
matrix,
leading
to
renal
tissue
damage
and
impaired
function,
ultimately
progressing
failure.
Current
clinical
treatments
CKD
mainly
focus
on
managing
primary
diseases,
with
no
specific
drugs
targeting
fibrosis.
The
pathogenesis
complex,
there
are
currently
available
reverse
it.
A
comprehensive
overview
fibrosis,
alongside
a
summary
current
anti-fibrotic
therapies,
including
some
that
already
used
clinically
slow
function
progression,
new
in
trials,
emerging
targeted
could
provide
theoretical
foundations
perspectives
treatment
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(42), С. 23211 - 23223
Опубликована: Окт. 11, 2024
Gut
microbiota
provides
an
important
insight
into
clarifying
the
mechanism
of
active
substances
with
low
bioavailability,
but
its
specific
action
varied
case
by
and
remained
unclear.
Dihydroquercetin
(DHQ)
is
a
bioactive
flavonoid
which
showed
beneficial
effects
on
colitis
alleviation
gut
modulation.
Herein,
we
aimed
to
explore
microbiota-dependent
anticolitis
DHQ
in
sight
metabolites
their
interactions
microRNAs
(miRNAs).
Dietary
supplementation
alleviated
dextran
sulfate
sodium-induced
phenotypes
improved
dysbiosis.
Fecal
transplantation
further
revealed
that
activity
was
mediated
microbiota.
To
clarify
how
modulated
mice,
tandem
analyses
microbiome
targeted
metabolome
were
performed,
altered
profiles
metabolite
short-chain
fatty
acids
(SCFAs)
bile
producers
observed
DHQ-treated
mice.
In
addition,
SCFA
treatment
compared
acids,
along
inhibition
phosphoinositide-3-kinase
(PI3K)-protein
kinase
B
(Akt)
pathway.
Subsequently,
colonic
miRNA
profile
mice
receiving
sequenced,
differentially
expressed
miR-10a-5p
identified.
Both
prediction
analysis
dual-luciferase
reporter
assay
indicated
directly
bind
3'-untranslated
regions
gene
Food Reviews International,
Год журнала:
2024,
Номер
unknown, С. 1 - 29
Опубликована: Авг. 5, 2024
The
incidence
of
kidney
diseases
is
increasing
globally,
posing
a
serious
threat
to
human
health.
Studies
have
shown
that
apigenin,
natural
dietary
flavonoid
with
multiple
bioactivities,
may
be
effective
in
protecting
the
kidneys
and
treating
variety
diseases.
This
review
collates
discusses
available
evidence
on
therapeutic
effects
apigenin
common
In
addition,
specific
molecular
mechanisms
by
which
exerts
its
renoprotective
are
described,
informs
further
research
clinical
nutritional
applications
field
renal
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 1942 - 1942
Опубликована: Авг. 23, 2024
Chronic
kidney
disease
(CKD)
is
a
major
global
health
concern.
Renal
fibrosis,
prevalent
outcome
regardless
of
the
initial
cause,
ultimately
leads
to
end-stage
renal
disease.
Glomerulosclerosis
and
interstitial
fibrosis
are
primary
pathological
features.
Preventing
slowing
considered
effective
strategies
for
delaying
CKD
progression.
However,
treatments
lacking.
Sirtuin
1
(SIRT1),
nicotinamide
adenine
dinucleotide
(NAD+)-dependent
deacetylase
belonging
class
III
histone
deacetylases,
implicated
in
physiological
regulation
protection
susceptible
diverse
array
influences,
as
demonstrated
previous
studies.
Interestingly,
controversial
conclusions
have
emerged
research
has
progressed.
This
review
provides
comprehensive
summary
current
understanding
advancements
field;
specifically,
biological
roles
mechanisms
SIRT1
regulating
These
include
aspects
such
lipid
metabolism,
epithelial-mesenchymal
transition,
oxidative
stress,
aging,
inflammation,
autophagy.
manuscript
explores
potential
therapeutic
target
offers
new
perspectives
on
treatment
approaches
prognostic
assessments.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 20, 2024
The
rising
incidence
of
fibrosis
poses
a
major
threat
to
global
public
health,
and
the
continuous
exploration
natural
products
for
effective
treatment
fibrotic
diseases
is
crucial.
Berberine
(BBR),
an
isoquinoline
alkaloid,
widely
used
clinically
its
anti-inflammatory,
anti-tumor
anti-fibrotic
pharmacological
effects.
Until
now,
researchers
have
worked
explore
mechanisms
BBR
fibrosis,
multiple
studies
found
that
attenuates
through
different
pathways
such
as
TGF-β/Smad,
AMPK,
Nrf2,
PPAR-γ,
NF-κB,
Notch/snail
axis.
This
review
describes
mechanism
derivatives,
safety
evaluation
toxicity
BBR.
provides
important
therapeutic
clues
strategies
exploring
new
drugs
fibrosis.
Nevertheless,
more
studies,
especially
clinical
are
still
needed.
We
believe
with
implementation
high-quality
significant
progress
will
be
made
in
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2582 - 2582
Опубликована: Ноя. 12, 2024
Urinary
tract
infections
(UTIs)
are
common
bacterial
in
children.
UTIs
may
be
limited
to
the
bladder
or
involve
kidneys
with
possible
irreversible
damage.
Congenital
abnormalities
of
kidney
and
urinary
(CAKUT)
often
associated
UTIs;
scars
have
been
considered
a
consequence
untreated
but
congenital.
The
mechanism
by
which
bacteria
produce
inflammation
system
has
intensively
investigated.
Diagnostic
tools,
including
invasive
imaging
procedures,
advocated
infants
small
children
not
necessary
most
cases.
Effective
antibiotic
drugs
available,
prophylactic
treatment
questioned.
Several
guidelines
on
simple
one
for
general
practitioners
is
needed.
PubMed,
Год журнала:
2024,
Номер
49(8), С. 1353 - 1362
Опубликована: Авг. 28, 2024
Renal
fibrosis
is
the
common
pathological
basis
for
progressive
development
of
chronic
kidney
disease
(CKD)
caused
by
various
etiologies.
It
characterized
persistent
deposition
extracellular
matrix,
leading
to
renal
tissue
damage
and
impaired
function,
ultimately
progressing
failure.
Current
clinical
treatments
CKD
mainly
focus
on
managing
primary
diseases,
with
no
specific
drugs
targeting
fibrosis.
The
pathogenesis
complex,
there
are
currently
available
reverse
it.
A
comprehensive
overview
fibrosis,
alongside
a
summary
current
anti-fibrotic
therapies,
including
some
that
already
used
clinically
slow
function
progression,
new
in
trials,
emerging
targeted
could
provide
theoretical
foundations
perspectives
treatment
