Journal of Orthopaedic Surgery and Research,
Год журнала:
2024,
Номер
19(1)
Опубликована: Дек. 5, 2024
Low
back
pain
caused
by
intervertebral
disc
degeneration
(IDD)
has
emerged
as
a
significant
global
public
health
concern,
with
far-reaching
consequences
for
patients'
quality
of
life
and
healthcare
systems.
Although
previous
research
have
revealed
that
the
mechanisms
cell
apoptosis,
pyroptosis
necroptosis
can
aggravate
IDD
damage
mediating
inflammation
promoting
extracellular
matrix
degradation,
but
they
cannot
explain
connection
between
different
death
ion
metabolism
disorders.
The
latest
study
shows
such
cellular
senescence,
ferroptosis,
cuproptosis,
PANopotosis
similar
roles
in
progression
degeneration,
not
exactly
same
mechanism.
This
paper
summarizes
effects
various
patterns
on
disease
IDD,
related
molecular
signaling
pathways,
providing
new
perspectives
potential
clinical
intervention
strategies
prevention
treatment
IDD.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 5, 2024
Abstract
Copper
is
a
crucial
trace
element
that
plays
role
in
various
pathophysiological
processes
the
human
body.
also
acts
as
transition
metal
involved
redox
reactions,
contributing
to
generation
of
reactive
oxygen
species
(ROS).
Under
prolonged
and
increased
ROS
levels,
oxidative
stress
occurs,
which
has
been
implicated
different
types
regulated
cell
death.
The
recent
discovery
cuproptosis,
copper-dependent
death
pathway
distinct
from
other
known
forms,
raised
interest
researchers
field
cancer
therapy.
Herein,
present
work
aims
outline
current
understanding
with
an
emphasis
on
its
anticancer
activities
through
interplay
copper-induced
stress,
thereby
providing
new
ideas
for
therapeutic
approaches
targeting
modes
future.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 1, 2024
Copper
plays
vital
roles
in
numerous
cellular
processes
and
its
imbalance
can
lead
to
oxidative
stress
dysfunction.
Recent
research
has
unveiled
a
unique
form
of
copper-induced
cell
death,
termed
cuproptosis,
which
differs
from
known
death
mechanisms.
This
process
involves
the
interaction
copper
with
lipoylated
tricarboxylic
acid
cycle
enzymes,
causing
protein
aggregation
death.
Recently,
growing
number
studies
have
explored
link
between
cuproptosis
cancer
development.
review
comprehensively
examines
systemic
metabolism
copper,
including
tumor-related
signaling
pathways
influenced
by
copper.
It
delves
into
discovery
mechanisms
connection
various
cancers.
Additionally,
suggests
potential
treatments
using
ionophores
that
induce
combination
small
molecule
drugs,
for
precision
therapy
specific
types.
Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Сен. 26, 2024
Abstract
Long
non-coding
RNAs
(lncRNAs)
have
emerged
as
crucial
regulators
in
various
cellular
processes,
including
cancer
progression
and
stress
response.
Recent
studies
demonstrated
that
copper
accumulation
induces
a
unique
form
of
cell
death
known
cuproptosis,
with
lncRNAs
playing
key
role
regulating
cuproptosis-associated
pathways.
These
may
trigger
cell-specific
responses
to
stress,
presenting
new
opportunities
prognostic
markers
therapeutic
targets.
This
paper
delves
into
the
cuproptosis-mediated
cancer,
underscoring
their
potential
biomarkers
targets
for
innovative
strategies.
A
thorough
review
scientific
literature
was
conducted,
utilizing
databases
such
PubMed,
Google
Scholar,
ScienceDirect,
search
terms
like
'lncRNAs,'
'cuproptosis,'
'cancer.'
Studies
were
selected
based
on
relevance
lncRNA
regulation
cuproptosis
pathways
implications
prognosis
treatment.
The
highlights
significant
contribution
cuproptosis-related
genes
pathways,
impacting
metabolism,
mitochondrial
responses,
apoptotic
signaling.
Specific
are
breast,
lung,
liver,
ovarian,
pancreatic,
gastric
cancers.
objective
this
article
is
explore
cancers
mediated
by
cuproptosis.
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2024,
Номер
1879(4), С. 189124 - 189124
Опубликована: Май 25, 2024
Apoptosis
has
traditionally
been
regarded
as
the
desired
cell
death
pathway
activated
by
chemotherapeutic
drugs
due
to
its
controlled
and
non-inflammatory
nature.
However,
recent
discoveries
of
alternative
pathways
have
paved
way
for
immune-stimulatory
treatment
approaches
in
cancer.
Ferroptosis
(dependent
on
iron)
cuproptosis
copper)
hold
promise
selective
cancer
targeting
overcoming
drug
resistance.
Copper
ionophores
iron-bearing
nano-drugs
show
potential
clinical
therapy
single
agents
adjuvant
treatments.
Here
we
review
up-to-date
evidence
involvement
metal
ion-dependent
cytotoxicity
classical
(alkylating
agents,
topoisomerase
inhibitors,
antimetabolites,
mitotic
spindle
inhibitors)
their
combinations
with
ferroptosis
inducers,
indicating
prospects,
advantages,
obstacles
use.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
