Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 28, 2025

This study aimed to elucidate the potential causal relationship between 4,907 plasma proteins and risk of gastric cancer using a two-sample Mendelian randomization approach. We utilized genome-wide association (GWAS) data perform analyses, treating as exposure factors outcome. Instrumental variables for were selected based on strongly correlated SNPs identified through processing screening GWAS provided by deCode database. employed set statistical methods centered inverse variance weighting (IVW) analysis estimate odds ratios (ORs) effects these susceptibility. According IVW method, 14 associated with (p < 0.005). Specifically, CHST15 (OR = 0.7553, 95% CI 0.6346 − 0.8988), L1CAM 0.7230, 0.5876 0.8896), FTMT 0.8246, 0.7241 0.9391), PMM2 0.5767, 0.3943 0.8433) negatively GASTRIC CANCER, whereas ABO 1.1868, 1.0638 1.3240), FAM3D 1.2109, 1.0850 1.3515), FAM3B 1.2988, 1.0953 1.5402), ADH7 1.3568, 1.1044 1.6670), MAP1LC3A 1.3704, 1.1194 1.6778), PGLYRP1 1.4071, 1.1235 1.7623), PDE5A 1.7446, 1.2693 2.3978), GLUL 3.1203, 1.5017 6.4839), NFE2L1 3.1759, 1.6163 6.2402), MAFG 3.1945, 1.5329 6.6575) positively correlated. Convergent results from Weighted Median MR-Egger analyses confirmed associations. Reverse indicated that does not significantly alter levels > 0.05). Sensitivity including assessments heterogeneity horizontal pleiotropy, robustness reliability our findings without significant bias. Pathway enrichment gene expression proteins, GO KEGG pathways, revealed CHST15, L1CAM, FTMT, may serve protective against cancer, while ABO, FAM3D, FAM3B, ADH7, MAP1LC3A, PGLYRP1, PDE5A, GLUL, NFE2L1, contribute pathogenesis. These highlight complex biological interactions tumorigenesis, providing valuable insights preventive therapeutic strategies in malignancy management.

Язык: Английский

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Advances in exosome modulation of ferroptosis for the treatment of orthopedic diseases

Pathology - Research and Practice, Год журнала: 2024, Номер 257, С. 155312 - 155312

Опубликована: Апрель 22, 2024

Язык: Английский

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Engineered small extracellular vesicle-mediated ferroptosis: A new frontier in cancer immunotherapy

International Immunopharmacology, Год журнала: 2024, Номер 139, С. 112621 - 112621

Опубликована: Июль 15, 2024

Язык: Английский

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Mendelian Randomization Analysis of Plasma Proteins Reveals Potential Novel Tumor Markers for Gastric Cancer

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

This study aimed to elucidate the potential causal relationship between 4,907 plasma proteins and risk of gastric cancer using a two-sample Mendelian randomization approach. We utilized genome-wide association (GWAS) data perform analyses, treating as exposure factors outcome. Instrumental variables for were selected based on strongly correlated SNPs identified through processing screening GWAS provided by deCode database. employed set statistical methods centered inverse variance weighting (IVW) analysis estimate odds ratios (ORs) effects these susceptibility. According IVW method, 14 associated with (p < 0.005). Specifically, CHST15 (OR = 0.7553, 95% CI 0.6346 − 0.8988), L1CAM 0.7230, 0.5876 0.8896), FTMT 0.8246, 0.7241 0.9391), PMM2 0.5767, 0.3943 0.8433) negatively cancer, whereas ABO 1.1868, 1.0638 1.3240), FAM3D 1.2109, 1.0850 1.3515), FAM3B 1.2988, 1.0953 1.5402), ADH7 1.3568, 1.1044 1.6670), MAP1LC3A 1.3704, 1.1194 1.6778), PGLYRP1 1.4071, 1.1235 1.7623), PDE5A 1.7446, 1.2693 2.3978), GLUL 3.1203, 1.5017 6.4839), NFE2L1 3.1759, 1.6163 6.2402), MAFG 3.1945, 1.5329 6.6575) positively correlated. Convergent results from Weighted Median MR-Egger analyses confirmed associations. Reverse indicated that does not significantly alter levels > 0.05). Sensitivity including assessments heterogeneity horizontal pleiotropy, robustness reliability our findings without significant bias. Pathway enrichment gene expression proteins, GO KEGG pathways, revealed CHST15, L1CAM, FTMT, may serve protective against while ABO, FAM3D, FAM3B, ADH7, MAP1LC3A, PGLYRP1, PDE5A, GLUL, NFE2L1, contribute pathogenesis. These highlight complex biological interactions tumorigenesis, providing valuable insights preventive therapeutic strategies in malignancy management.

Язык: Английский

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Scientific investigation of non-coding RNAs in mitochondrial epigenetic and aging disorders: Current nanoengineered approaches for their therapeutic improvement

Mitochondrion, Год журнала: 2024, Номер 80, С. 101979 - 101979

Опубликована: Ноя. 5, 2024

Язык: Английский

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