Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 28, 2025

This study aimed to elucidate the potential causal relationship between 4,907 plasma proteins and risk of gastric cancer using a two-sample Mendelian randomization approach. We utilized genome-wide association (GWAS) data perform analyses, treating as exposure factors outcome. Instrumental variables for were selected based on strongly correlated SNPs identified through processing screening GWAS provided by deCode database. employed set statistical methods centered inverse variance weighting (IVW) analysis estimate odds ratios (ORs) effects these susceptibility. According IVW method, 14 associated with (p < 0.005). Specifically, CHST15 (OR = 0.7553, 95% CI 0.6346 − 0.8988), L1CAM 0.7230, 0.5876 0.8896), FTMT 0.8246, 0.7241 0.9391), PMM2 0.5767, 0.3943 0.8433) negatively GASTRIC CANCER, whereas ABO 1.1868, 1.0638 1.3240), FAM3D 1.2109, 1.0850 1.3515), FAM3B 1.2988, 1.0953 1.5402), ADH7 1.3568, 1.1044 1.6670), MAP1LC3A 1.3704, 1.1194 1.6778), PGLYRP1 1.4071, 1.1235 1.7623), PDE5A 1.7446, 1.2693 2.3978), GLUL 3.1203, 1.5017 6.4839), NFE2L1 3.1759, 1.6163 6.2402), MAFG 3.1945, 1.5329 6.6575) positively correlated. Convergent results from Weighted Median MR-Egger analyses confirmed associations. Reverse indicated that does not significantly alter levels > 0.05). Sensitivity including assessments heterogeneity horizontal pleiotropy, robustness reliability our findings without significant bias. Pathway enrichment gene expression proteins, GO KEGG pathways, revealed CHST15, L1CAM, FTMT, may serve protective against cancer, while ABO, FAM3D, FAM3B, ADH7, MAP1LC3A, PGLYRP1, PDE5A, GLUL, NFE2L1, contribute pathogenesis. These highlight complex biological interactions tumorigenesis, providing valuable insights preventive therapeutic strategies in malignancy management.

Language: Английский

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Advances in exosome modulation of ferroptosis for the treatment of orthopedic diseases

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 257, P. 155312 - 155312

Published: April 22, 2024

Language: Английский

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Engineered small extracellular vesicle-mediated ferroptosis: A new frontier in cancer immunotherapy

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 139, P. 112621 - 112621

Published: July 15, 2024

Language: Английский

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Mendelian Randomization Analysis of Plasma Proteins Reveals Potential Novel Tumor Markers for Gastric Cancer

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

This study aimed to elucidate the potential causal relationship between 4,907 plasma proteins and risk of gastric cancer using a two-sample Mendelian randomization approach. We utilized genome-wide association (GWAS) data perform analyses, treating as exposure factors outcome. Instrumental variables for were selected based on strongly correlated SNPs identified through processing screening GWAS provided by deCode database. employed set statistical methods centered inverse variance weighting (IVW) analysis estimate odds ratios (ORs) effects these susceptibility. According IVW method, 14 associated with (p < 0.005). Specifically, CHST15 (OR = 0.7553, 95% CI 0.6346 − 0.8988), L1CAM 0.7230, 0.5876 0.8896), FTMT 0.8246, 0.7241 0.9391), PMM2 0.5767, 0.3943 0.8433) negatively cancer, whereas ABO 1.1868, 1.0638 1.3240), FAM3D 1.2109, 1.0850 1.3515), FAM3B 1.2988, 1.0953 1.5402), ADH7 1.3568, 1.1044 1.6670), MAP1LC3A 1.3704, 1.1194 1.6778), PGLYRP1 1.4071, 1.1235 1.7623), PDE5A 1.7446, 1.2693 2.3978), GLUL 3.1203, 1.5017 6.4839), NFE2L1 3.1759, 1.6163 6.2402), MAFG 3.1945, 1.5329 6.6575) positively correlated. Convergent results from Weighted Median MR-Egger analyses confirmed associations. Reverse indicated that does not significantly alter levels > 0.05). Sensitivity including assessments heterogeneity horizontal pleiotropy, robustness reliability our findings without significant bias. Pathway enrichment gene expression proteins, GO KEGG pathways, revealed CHST15, L1CAM, FTMT, may serve protective against while ABO, FAM3D, FAM3B, ADH7, MAP1LC3A, PGLYRP1, PDE5A, GLUL, NFE2L1, contribute pathogenesis. These highlight complex biological interactions tumorigenesis, providing valuable insights preventive therapeutic strategies in malignancy management.

Language: Английский

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Scientific investigation of non-coding RNAs in mitochondrial epigenetic and aging disorders: Current nanoengineered approaches for their therapeutic improvement

Mitochondrion, Journal Year: 2024, Volume and Issue: 80, P. 101979 - 101979

Published: Nov. 5, 2024

Language: Английский

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