The roles of lncRNAs in the development of drug resistance of oral cancers
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
180, С. 117458 - 117458
Опубликована: Окт. 15, 2024
Язык: Английский
cGAS/STING in skin melanoma: from molecular mechanisms to therapeutics
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 18, 2024
Язык: Английский
Resveratrol enhances the protective effects of calcium supplements on spinal cord injury–induced osteoporosis by targeting the SIRT1/FOXO3a pathway
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 17, 2024
Язык: Английский
Targeting non-coding RNAs as a promising biomarker in peritoneal metastasis: Background, mechanism, and therapeutic approach
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117294 - 117294
Опубликована: Сен. 2, 2024
Peritoneal
metastasis
(PM)
pathophysiology
is
complex
and
not
fully
understood.
PM,
originating
from
gastrointestinal
(GI)
cancer,
a
condition
that
significantly
worsens
patient
prognosis
due
to
its
nature
limited
treatment
options.
The
non-coding
RNAs
(ncRNAs)
have
been
shown
play
pivotal
roles
in
cancer
biology,
influencing
tumorigenesis,
progression,
metastasis,
therapeutic
resistance.
Increasing
evidence
has
demonstrated
the
regulatory
functions
of
different
classes
ncRNAs,
including
microRNAs
(miRNAs)
long
(lncRNAs)
PM.
Identifying
biomarkers
for
early
detection
PM
crucial
step
towards
improving
outcomes,
how
ncRNA
profiles
correlate
with
survival
rates,
response
therapy,
recurrence
risks
raised
much
attention
recent
years.
Additionally,
exploring
innovative
approaches
utilizing
such
as
targeted
therapy
gene
silencing,
may
offer
new
horizons
treating
this
dire
condition.
Recent
advances
systemic
treatments
development
novel
loco-regional
therapies
opened
doors
multimodal
approaches.
Radical
surgeries
combined
hyperthermic
intraperitoneal
chemotherapy
(HIPEC)
promising
results,
leading
extended
survival.
Current
research
focused
on
molecular
characterization
which
developing
future
strategies.
By
summarizing
latest
findings,
study
underscores
transformative
potential
ncRNAs
enhancing
diagnosis,
prognosis,
GI
paving
way
more
personalized
effective
clinical
Язык: Английский
Role of Phytochemicals in Treatment of Aging and Cancer: Focus on Mechanism of FOXO3 Activation
Antioxidants,
Год журнала:
2024,
Номер
13(9), С. 1099 - 1099
Опубликована: Сен. 11, 2024
There
have
been
many
studies
reporting
that
the
regular
consumption
of
fruits
and
vegetables
is
associated
with
reduced
risks
cancer
age-related
chronic
diseases.
Recent
demonstrated
reducing
reactive
oxygen
species
inflammation
by
phytochemicals
derived
from
natural
sources
can
extend
lifespans
in
a
range
model
organisms.
Phytochemicals
known
to
display
both
preventative
suppressive
activities
against
various
types
via
vitro
vivo
research
interfering
cellular
processes
critical
for
tumor
development.
The
current
challenge
lies
creating
tailored
supplements
containing
specific
individual
needs.
Achieving
this
goal
requires
deeper
understanding
molecular
mechanisms
through
which
affect
human
health.
In
review,
we
examine
recently
(from
2010
2024)
reported
plant
extracts
established
anti-aging
anti-cancer
effects
activation
FOXO3
transcriptional
factor.
Additionally,
provide
an
overview
these
molecules
exert
their
systems.
Lastly,
discuss
limitations
approach
outline
potential
future
directions
field.
Язык: Английский