Current Psychiatry Reports,
Год журнала:
2019,
Номер
21(9)
Опубликована: Авг. 13, 2019
Poor
treatment
response
is
a
hallmark
of
major
depressive
disorder.
To
tackle
this
problem,
recent
neuroimaging
studies
have
sought
to
characterize
antidepressant
in
terms
pretreatment
differences
intrinsic
functional
brain
networks.
Our
aim
review
that
predict
using
network
connectivity.
We
discuss
current
methodological
limitations
and
directions
for
future
biomarker
studies.
Functional
connectivity
stemming
from
the
subgenual
rostral
anterior
cingulate
has
shown
particular
consistency
predicting
response.
Differences
may
prove
fruitful
differentiating
responders
many
interventions.
Future
should
integrate
biological
MDD
subtypes
address
disorder's
inherent
clinical
heterogeneity.
These
scientific
advancements
potential
population
marked
by
limited
Methodological
considerations,
including
patient
selection,
criteria,
model
overfitting,
will
require
investigation
ensure
biomarkers
generalize
prospective
prediction
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 10, 2024
Abstract
Although
neuroimaging
has
been
widely
applied
in
psychiatry,
much
of
the
exuberance
decades
past
tempered
by
failed
replications
and
a
lack
definitive
evidence
to
support
utility
imaging
inform
clinical
decisions.
There
are
multiple
promising
ways
forward
demonstrate
relevance
for
psychiatry
at
individual
patient
level.
Ultra-high
field
magnetic
resonance
is
developing
as
sensitive
measure
neurometabolic
processes
particular
that
holds
promise
new
way
characterize
abnormalities
well
variability
response
treatment.
Neuroimaging
may
also
be
particularly
suited
science
brain
stimulation
interventions
given
can
both
targeting
changes
circuit
communication
function
how
effectively
improve
symptoms.
We
argue
greater
focus
on
data
will
pave
stronger
care
psychiatry.
stress
importance
using
symptom-relevant
experimental
manipulations
best
demonstrated
pairing
with
differential
treatment
prediction
outcome
measurement.
The
priorities
shifting,
which
compels
solidify
patients
over
exploratory
associations
biomarkers
ultimately
fail
replicate.
JAMA Psychiatry,
Год журнала:
2024,
Номер
81(5), С. 437 - 437
Опубликована: Март 6, 2024
Importance
Posttraumatic
stress
disorder
(PTSD)
is
a
common
psychiatric
that
particularly
difficult
to
treat
in
military
veterans.
Noninvasive
brain
stimulation
has
significant
potential
as
novel
treatment
reduce
PTSD
symptoms.
Objective
To
test
whether
active
transcranial
direct
current
(tDCS)
plus
virtual
reality
(VR)
superior
sham
tDCS
VR
for
warzone-related
PTSD.
Design,
Setting,
and
Participants
This
double-blind
randomized
clinical
trial
was
conducted
among
US
veterans
enrolled
from
April
2018
May
2023
at
secondary
care
Department
of
Veterans
Affairs
hospital
included
1-
3-month
follow-up
visits.
with
chronic
exposure,
recruited
via
referral
advertisement.
Patients
had
be
on
stable
regimen
least
6
weeks
eligible
enrollment.
Data
were
analyzed
September
2023.
Intervention
randomly
assigned
receive
2-mA
anodal
or
targeted
the
ventromedial
prefrontal
cortex,
during
six
25-minute
sessions
standardized
warzone
delivered
over
2
3
weeks.
Main
Outcomes
Measures
The
co–primary
outcomes
self-reported
symptoms,
measured
checklist
DSM-5
(PCL-5),
alongside
quality
life.
Other
psychophysiological
arousal,
clinician-assessed
PTSD,
depression,
social/occupational
function.
Results
A
total
54
participants
(mean
[SD]
age,
45.7
[10.5]
years;
51
[94%]
males)
assessed,
including
26
group
28
group.
reported
reduction
symptom
severity
1
month
(
t
=
−2.27,
P
.02;
Cohen
d
−0.82).
There
no
differences
life
between
groups.
Active
significantly
accelerated
habituation
events
compared
F
5,7689.8
4.65;
<
.001).
Adverse
effects
consistent
known
safety
profile
corresponding
interventions.
Conclusions
Relevance
These
findings
suggest
combined
may
promising
strategy
underscore
innovative
these
technologies.
Trial
Registration
ClinicalTrials.gov
Identifier:
NCT03372460
Brain Sciences,
Год журнала:
2024,
Номер
14(3), С. 210 - 210
Опубликована: Фев. 24, 2024
First-line
treatments
for
post-traumatic
stress
disorder
(PTSD)
encompass
a
wide
range
of
pharmacotherapies
and
psychotherapies.
However,
many
patients
fail
to
respond
such
interventions,
highlighting
the
need
novel
approaches.
Due
its
ability
modulate
cortical
activity,
non-invasive
brain
stimulation
(NIBS)
could
represent
valuable
therapeutic
tool.
Therefore,
aim
this
systematic
review
is
summarize
discuss
existing
evidence
on
ameliorative
effects
NIBS
PTSD
comorbid
anxiety
depressive
symptoms.
Our
goal
also
debate
effectiveness
an
integrated
approach
characterized
by
combination
psychotherapy.
This
search
was
conducted
following
preferred
reporting
items
reviews
meta-analyses
(PRISMA)
guidelines
in
PubMed,
PsycINFO,
PsycARTICLES,
PSYINDEX,
MEDLINE,
ERIC
databases.
Overall,
31
studies
met
eligibility
criteria,
yielding
total
26
clinical
trials
employing
transcranial
magnetic
(TMS)
5
making
use
direct-current
(tDCS).
From
these
studies,
it
emerged
that
consistently
reduced
overall
symptoms'
severity
as
well
Moreover,
we
speculate
combining
with
prolonged
exposure
or
cognitive
processing
therapy
might
promising
ameliorating
subjects'
conditions.
Current Psychiatry Reports,
Год журнала:
2019,
Номер
21(9)
Опубликована: Авг. 13, 2019
Poor
treatment
response
is
a
hallmark
of
major
depressive
disorder.
To
tackle
this
problem,
recent
neuroimaging
studies
have
sought
to
characterize
antidepressant
in
terms
pretreatment
differences
intrinsic
functional
brain
networks.
Our
aim
review
that
predict
using
network
connectivity.
We
discuss
current
methodological
limitations
and
directions
for
future
biomarker
studies.
Functional
connectivity
stemming
from
the
subgenual
rostral
anterior
cingulate
has
shown
particular
consistency
predicting
response.
Differences
may
prove
fruitful
differentiating
responders
many
interventions.
Future
should
integrate
biological
MDD
subtypes
address
disorder's
inherent
clinical
heterogeneity.
These
scientific
advancements
potential
population
marked
by
limited
Methodological
considerations,
including
patient
selection,
criteria,
model
overfitting,
will
require
investigation
ensure
biomarkers
generalize
prospective
prediction
