Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 2, 2024
Язык: Английский
Materials Science and Engineering R Reports, Год журнала: 2024, Номер 159, С. 100805 - 100805
Опубликована: Май 29, 2024
Язык: Английский
Процитировано
21
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(8), С. 4740 - 4756
Опубликована: Июль 1, 2024
Early detection of cancer is vital for increasing patient survivability chances. The three major techniques used to diagnose cancers are instrumental examination, tissue biopsy, and tumor biomarker detection. Circulating DNA (ctDNA) has gained much attention in recent years due advantages over traditional technology, such as high sensitivity, specificity, noninvasive nature. Through the mechanism apoptosis, necrosis, circulating exosome release cells, ctDNA can spread throughout circulatory system carry modifications methylations, mutations, gene rearrangements, microsatellite instability. Traditional gene-detection technology struggles achieve real-time, low-cost, portable measurement, whereas electrochemical biosensors offer low cost, specificity alongside portability ctDNA. Therefore, this review focuses on describing advancements biomarkers various types biosensor developments noninvasive, rapid Further review, sensors also discussed regards their selections probes receptors based electrode surface recognition elements.
Язык: Английский
Процитировано
19
Small, Год журнала: 2023, Номер 19(15)
Опубликована: Янв. 11, 2023
Abstract Liquid biopsy for the analysis of circulating cancer biomarkers (CBs) is a major advancement toward early detection cancer. In comparison to tissue techniques, liquid relatively painless, offering multiple sampling opportunities across easily accessible bodily fluids such as blood, urine, and saliva. also inexpensive simple, avoiding requirement specialized laboratory equipment or trained medical staff. Major advances in field are attributed largely developments nanotechnology microfabrication that enables creation highly precise chip‐based platforms. These devices can overcome limitations an individual biomarker by detecting markers simultaneously on same chip, featuring integrated combined target separation techniques. this review, portable semi‐portable micro, nano, multiplexed platforms CB diagnosis highlighted. A comparative discussion provided, noting merits drawbacks platforms, especially terms portability. Finally, key challenges device portability possible solutions, well discussing future direction
Язык: Английский
Процитировано
43
Biosensors, Год журнала: 2023, Номер 13(4), С. 426 - 426
Опубликована: Март 27, 2023
In comparison with traditional clinical diagnosis methods, field−effect transistor (FET)−based biosensors have the advantages of fast response, easy miniaturization and integration for high−throughput screening, which demonstrates their great technical potential in biomarker detection platform. This mini review mainly summarizes recent advances FET biosensors. Firstly, gives an overview design strategies sensitive assay, including structures devices, functionalization methods semiconductor materials used. Having established this background, then focuses on following aspects: immunoassay based a single biosensor disease diagnosis; efficient into large−area array, where multiplexing provides valuable insights testing options; microfluidics, contributes to rapid development lab−on−chip (LOC) sensing platforms other types sensors multifunctional applications. Finally, we summarize long−term prospects commercialization systems.
Язык: Английский
Процитировано
40
Sensors, Год журнала: 2023, Номер 23(15), С. 6808 - 6808
Опубликована: Июль 30, 2023
As a new type of one-dimensional semiconductor nanometer material, silicon nanowires (SiNWs) possess good application prospects in the field biomedical sensing. SiNWs have excellent electronic properties for improving detection sensitivity biosensors. The combination and effect transistors (FETs) formed one special biosensor with high target selectivity real-time label-free. Recently, SiNW-FETs received more attention fields detection. Here, we give critical review progress SiNW-FETs, particular, about reversible surface modification methods. Moreover, summarized applications DNA, protein, microbial We also discuss related working principle technical approaches. Our provides an extensive discussion studying challenges future development SiNW-FETs.
Язык: Английский
Процитировано
24
Small Methods, Год журнала: 2021, Номер 6(1)
Опубликована: Дек. 15, 2021
Wearable piezoresistive sensors are being developed as electronic skins (E-skin) for broad applications in human physiological monitoring and soft robotics. Tactile with sufficient sensitivities, durability, large dynamic ranges required to replicate this critical component of the somatosensory system. Multiple micro/nanostructures, materials, sensing modalities have been reported address need. However, a trade-off arises between device performance complexity. Inspired by microstructure spinosum at dermo epidermal junction skin, low-cost, scalable, high-performance sensor is high sensitivity (0.144 kPa
Язык: Английский
Процитировано
57
Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(25), С. 5715 - 5747
Опубликована: Янв. 1, 2023
This review mainly provides a comprehensive discussion on the detection of lung cancer markers such as miRNA, DNA and proteins using biosensors electrochemical, optical nanopore developed in past 5 years.
Язык: Английский
Процитировано
22
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 12, 2024
Abstract Cancer stem cells (CSCs) represent both a key driving force and therapeutic target of tumoral carcinogenesis, tumor evolution, progression, recurrence. CSC-guided diagnosis, treatment, surveillance are strategically significant in improving cancer patients’ overall survival. Due to the heterogeneity plasticity CSCs, high sensitivity, specificity, outstanding targeting demanded for CSC detection targeting. Nanobiotechnologies, including biosensors, nano-probes, contrast enhancers, drug delivery systems, share identical features required. Implementing these techniques may facilitate performance In this review, we focus on some most recent advances how nanobiotechnologies leverage characteristics optimize diagnosis treatment liquid biopsy, clinical imaging, nano-treatment. Specifically, attributes maximize circulating DNA, cells, exosomes, improve positron emission computed tomography magnetic resonance enhance effects cytotoxic therapy, photodynamic immunotherapy radioimmunotherapy reviewed.
Язык: Английский
Процитировано
8
Biosensors, Год журнала: 2022, Номер 12(8), С. 649 - 649
Опубликована: Авг. 17, 2022
Early diagnosis and treatment have always been highly desired in the fight against cancer, detection of circulating tumor DNA (ctDNA) has recently touted as promising for early cancer-screening. Consequently, ctDNA liquid biopsy is gaining much attention field treatment, which also attracted research interest from industry. However, it difficult to achieve low-cost, real-time, portable measurement traditional gene-detection technology. Electrochemical biosensors become a solution due their unique advantages such high sensitivity, specificity, low cost, good portability. Therefore, this review aims discuss latest developments minimally invasive, rapid, real-time detection. Various sensors are reviewed with respect choices receptor probes, designs electrodes, strategies, preparation samples, figures merit, sorted by type electrode surface recognition elements. The development Internet Things, point-of-care testing, big data, health analyzed, focus on portable, non-destructive characteristics.
Язык: Английский
Процитировано
26
ACS Omega, Год журнала: 2022, Номер 7(26), С. 22073 - 22088
Опубликована: Июнь 22, 2022
Advances in nanotechnology over the past decade have emerged as a substitute for conventional therapies and facilitated development of economically viable biosensors. Next-generation biosensors can play significant role curbing spread various viruses, including HCoV-2, controlling morbidity mortality. Pertaining to impact current pandemic, there is need point-of-care biosensor-based testing detection method accelerate process. Integrating with nanostructures could be ultrasensitive label-free amplify sensing miniaturization. Notably, next-generation expedite An elaborate description types functionalized nanomaterials their synthetic aspects presented. The utility nanostructured materials fabricating nanobiosensors detect several viral infections described this review. This review also discusses choice appropriate nanomaterials, well challenges opportunities field nanobiosensors.
Язык: Английский
Процитировано
24