Pathology - Research and Practice, Год журнала: 2023, Номер 248, С. 154663 - 154663
Опубликована: Июль 6, 2023
Язык: Английский
Talanta, Год журнала: 2023, Номер 268, С. 125280 - 125280
Опубликована: Окт. 12, 2023
Язык: Английский
Процитировано
58
Journal of Pharmaceutical Analysis, Год журнала: 2023, Номер 13(12), С. 1429 - 1451
Опубликована: Авг. 24, 2023
With the continuous discovery and research of predictive cancer-related biomarkers, liquid biopsy shows great potential in cancer diagnosis. Surface-enhanced Raman scattering (SERS) microfluidic technology have received much attention among various biomarker detection methods. The former has ultrahigh sensitivity can provide a unique fingerprint. In contrast, latter characteristics miniaturization integration, which realize accurate control samples high-throughput through design. Both for point-of-care testing (POCT), their combination (lab-on-a-chip SERS (LoC-SERS)) good compatibility. this paper, basic situation circulating proteins, tumor cells, exosomes, DNA (ctDNA), microRNA (miRNA) diagnosis cancers is reviewed, these biomarkers by LoC-SERS platform recent years described detail. At same time, challenges future development are discussed at end review. Summarizing current expected to reference scholars engaged related work interested field.
Язык: Английский
Процитировано
35
Sensors, Год журнала: 2023, Номер 23(11), С. 5300 - 5300
Опубликована: Июнь 2, 2023
The treatment of cancers is a significant challenge in the healthcare context today. Spreading circulating tumor cells (CTCs) throughout body will eventually lead to cancer metastasis and produce new tumors near healthy tissues. Therefore, separating these invading extracting cues from them extremely important for determining rate progression inside development individualized treatments, especially at beginning process. continuous fast separation CTCs has recently been achieved using numerous techniques, some which involve multiple high-level operational protocols. Although simple blood test can detect presence circulation system, detection still restricted due scarcity heterogeneity CTCs. more reliable effective techniques thus highly desired. technology microfluidic devices promising among many other bio-chemical bio-physical technologies. This paper reviews recent developments two types devices, are based on size and/or density cells, cells. goal this review identify knowledge or gaps suggest future works.
Язык: Английский
Процитировано
27
Chemical Engineering Journal, Год журнала: 2024, Номер 482, С. 148851 - 148851
Опубликована: Янв. 18, 2024
Exosomes in body fluids are important liquid biopsy as they reflect the information of their originating cells. Thus, exosome analysis can provide valuable insights into diseases such cancer. However, low concentration exosomes is accompanied by background noise, making challenging. Here, a microfluidic chip which three-dimensional nanostructures were arranged herringbone pattern (nanochip) that could efficiently capture specific was developed. Nanostructures prepared stacking silica nanoparticles to enhance contact and interaction between structures, then improve mass transfer through micromixing. To analyze derived from human epidermal growth factor receptor 2 (HER2, an marker for cancer progression patient survival)-positive cancer, anti-HER2 antibody introduced nanochip approximately 97.7% efficiency confirmed. The performed better than chips with solid structure or without (solid flat chips). feasibility capturing multiple demonstrated using both vitro vivo samples employing dual configuration nanochips different antibodies interconnected series. This effectively HER2-positive has potential isolations. Additionally, this detect various disease-related because be applied; will useful exosome-based disease diagnosis monitoring biopsies.
Язык: Английский
Процитировано
12
Laser & Photonics Review, Год журнала: 2024, Номер 18(5)
Опубликована: Янв. 28, 2024
Abstract Liquid biopsy is regarded as a promising strategy for assisting precision medicine because of its convenience, noninvasiveness, and ability to overcome tumor heterogeneity achieve early detection. Recently, impressive advancements in plasmonic biosensors, artificial intelligence, portable Raman equipment have yielded unprecedented progress surface‐enhanced spectroscopy (SERS)–based point‐of‐care testing (POCT) systems liquid biopsy. The development these presents paradigm shift on‐site applications by leveraging the unique benefits efficiency, fast analysis, portability, affordability, user‐friendliness. Herein, advances are introduced over last 3 years field SERS‐based POCT labeled label‐free biomarker analysis body fluids, including circulating proteins cells, exosomes, micro‐RNA, DNA. Additionally, powerful machine learning algorithms (including deep algorithms) integrated with SERS effectively extract potential data features generate precise diagnostic models. review highlights use handheld devices significantly promoting application clinical scenarios. Finally, outlines challenges future perspectives this technology.
Язык: Английский
Процитировано
10
The Analyst, Год журнала: 2023, Номер 148(18), С. 4447 - 4455
Опубликована: Янв. 1, 2023
Development and characterization of TGF-β1 MIP electrochemical sensor as a tool for POC diagnostics.
Язык: Английский
Процитировано
18
Cancer Control, Год журнала: 2024, Номер 31
Опубликована: Янв. 1, 2024
Skin cancer comprises one-third of all diagnosed cases and remains a major health concern. Genetic environmental parameters serve as the two main risk factors associated with development skin cancer, ultraviolet radiation being most common factor. Studies have also found fair complexion, arsenic toxicity, indoor tanning, family history among prevailing causes cancer. Prevention early diagnosis play crucial role in reducing frequency ensuring effective management Recent studies focused on exploring minimally invasive or non-invasive diagnostic technologies along artificial intelligence to facilitate rapid accurate diagnosis. The treatment ranges from traditional surgical excision various advanced methods such phototherapy, radiotherapy, immunotherapy, targeted therapy, combination therapy. introduction new checkpoint inhibitors personalized immunotherapy enhancing efficacy. Advancements multi-omics, nanotechnology, further deepened understanding mechanisms underlying tumoral growth their interaction therapeutic effects, which has paved way for precision oncology. This review aims highlight recent advancements provide an overview existing emerging diagnostic, prognostic, modalities, while highlighting areas that require research bridge knowledge gaps.
Язык: Английский
Процитировано
7
Advanced Materials Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Abstract Multiplexed remote bio‐detection is demonstrated through an optical waveguide assembly coated with interferometric layers. Image conduits (IC)s, composed of 3012 individual cores, are layers tantalum pentoxide (Ta 2 O 5 ) and silica (SiO to transform each core into a sensitive sensor. The spectral response the IC as function refractive index (RI) changes obtained compared simulated one. experimental sensitivities resolutions cores assessed in detection mode by imaging assembly. For 75% sensitivity better than 510%. RIU −1 (RI Unit) obtained, corresponding resolution 7 × 10 −4 RIU. Furthermore, face functionalized two localized arrays hundred‐micrometer droplets containing different oligonucleotide (ODN) probes using polymeric 3D‐printed microcantilever. Hybridization complementary ODN strands detected for one probes, second being negative control. Interaction kinetics monitored areas grouping several or on cores. Thus, multiplexed surface first time paving way applications multiplex situ biosensing, and, ultimately, vivo endoscopic diagnosis.
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7077 - 7077
Опубликована: Апрель 11, 2023
According to the World Health Organization (WHO) forecasts, Antimicrobial Resistance (AMR) will be leading cause of death worldwide in next decades. To prevent this phenomenon, rapid Susceptibility Testing (AST) techniques are required drive selection most suitable antibiotic and its dosage. In context, we propose an on-chip platform, based on a micromixer microfluidic channel, combined with pattern engineered electrodes exploit di-electrophoresis (DEP) effect. The role is ensure proper interaction bacteria over long time (≈1 h), DEP-based channel enables efficient sorting live from dead bacteria. A efficiency more than 98%, low power consumption (Vpp = 1 V) response 5 s, within chip footprint ≈86 mm2, has been calculated, which makes proposed system very attractive innovative for monitoring antimicrobial susceptibility at single-bacterium level next-generation medicine.
Язык: Английский
Процитировано
15
Talanta, Год журнала: 2024, Номер 273, С. 125866 - 125866
Опубликована: Март 6, 2024
Язык: Английский
Процитировано
6