The
presence
of
fluoroquinolone
(FQs)
antibiotic
residues
in
the
food
and
environment
has
become
a
significant
concern
for
human
health
ecosystems.
In
this
study,
background-free
properties
upconversion
nanoparticles
(UCNPs),
high
specificity
target
aptamer
(Apt),
quenching
graphene
oxide
(GO)
were
integrated
into
microfluidic-based
fluorescence
biosensing
chip
(MFBC).
Interestingly,
microfluidic
channels
MFBC
prepared
by
laser-printing
technology
without
need
complex
preparation
processes
additional
specialized
equipment.
target-responsive
probes
loaded
on
self-assembly
UCNPs-Apt
with
GO
based
π-π
stacking
interactions,
which
can
be
used
detection
two
FQs
large
scale
multi-step
manipulations
reactions,
resulting
excellent
multiplexed,
automated
simultaneous
sensing
capabilities
limits
as
low
1.84
ng/mL
(enrofloxacin)
2.22
(ciprofloxacin).
addition,
was
smartphone
portable
device
to
enable
analysis
wide
range
field.
This
research
provides
simple-to-prepare
great
potential
field
applications
large-scale
screening
environment.
Micro,
Год журнала:
2023,
Номер
3(4), С. 822 - 866
Опубликована: Окт. 31, 2023
In
recent
years,
the
field
of
drug
delivery
has
seen
a
significant
shift
towards
exploration
and
utilization
nanoparticles
(NPs)
as
versatile
carriers
for
therapeutic
agents.
With
its
ability
to
provide
exact
control
over
NPs’
characteristics,
microfluidics
emerged
potent
platform
efficient
controlled
synthesis
NPs.
Microfluidic
devices
designed
precise
fluid
manipulation
at
micro-scale
offer
unique
tailoring
NP
properties,
enabling
enhanced
properties
such
size,
morphology,
size
distribution
while
ensuring
high
batch-to-batch
reproducibility.
Microfluidics
can
be
used
produce
liposomes,
solid
lipid
nanoparticles,
polymer-based
NPs,
lipid-polymer
hybrid
well
variety
inorganic
NPs
silica,
metal,
metal
oxide,
quantum
dots,
carbon-based
offering
composition
surface
properties.
Its
precision
in
holds
great
promise
advancing
NP-based
systems
both
clinical
industrial
settings.
Although
challenges
with
large-scale
production
still
remain,
offers
transformative
approach
synthesis.
this
review,
starting
from
historical
development
microfluidic
systems,
materials
create
microfabrication
methods,
system
components
will
discussed
order
reader
an
overview
systems.
following,
studies
on
fabrication
polymeric
are
included.
Advanced Optical Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 29, 2024
Abstract
Metamaterials
based
on
quasi‐bound
states
in
the
continuum
(qBICs)
with
manipulable
resonance
quality
(
Q
)
factors
have
provided
a
standout
platform
for
cutting‐edge
terahertz
(THz)
sensing
applications.
However,
most
so
far
been
implemented
as
conventional
metal
patch
structures
adjacent
substrate
layers,
incurring
limitation
of
insufficient
light‐matter
interaction
due
to
effects.
Here,
qBIC‐driven
metamaterials
substrate‐free
metallic
aperture
tailoring
interactions
and
exhibiting
near‐ideal
performance
is
introduced.
Specifically,
it
incorporated
ultrafast
femtosecond
laser
processing
technology
fabricate
H‐type
accessible
high‐contrast
factor
resonances
allowed
by
in‐plane
symmetry
breaking.
Correspondingly,
stronger
light
field
energies
are
applied
completely
eliminating
confinement
effect,
enabling
experimental
sensitivity
up
0.86
THz
RIU
−1
qBIC
resonance,
1.9
times
that
dipole
resonance.
Moreover,
high
achieved
optimized
asymmetry
parameter
exploited
detecting
ultrathin
layers
L‐proline
molecules
low
0.87
nmol.
It
envisioned
this
approach
will
deliver
insights
real‐time,
precise,
high‐performance
detection
trace
biomolecules,
open
new
perspectives
realizing
ideal
metadevices.
PLoS ONE,
Год журнала:
2025,
Номер
20(3), С. e0319392 - e0319392
Опубликована: Март 12, 2025
Breast
cancer
represents
a
significant
therapeutic
challenge
due
to
its
aggressive
nature
and
resistance
treatment.
A
major
cause
of
treatment
failure
in
breast
is
the
presence
rare,
low-proliferative
disseminated
tumor
cells
(DTCs)
distant
organs
including
bone
marrow.
This
study
introduced
microfluidic-based
approach
improve
immunodetection
isolation
these
rare
DTCs
for
downstream
analysis,
with
an
emphasis
on
optimizing
immunocapture,
release,
enrichment
methods
live
as
compared
standard
blood-borne
circulating
(CTCs).
EGFR
(epidermal
growth
factor
receptor)
EpCAM
(epithelial
cell
adhesion
molecule),
two
key
surface
markers
cancer,
were
validated
efficient
capture
targets
within
microfluidic
chambers.
Furthermore,
we
demonstrated
that
combination
0.25%
trypsin
impulse
was
most
effective
releasing
captured
cells,
maintaining
high
viability,
preserving
essential
cellular
characteristics.
Using
metastatic
mouse
model,
achieved
47.9-fold
DTCs.
Analysis
blood
marrow
samples
obtained
from
patient
minimal
residual
disease
at
timepoints
revealed
reduction
CTCs
increase
following
adjuvant
chemotherapy.
observation
suggested
potential
dynamic
interplay
between
response
therapy.
Our
results
underscore
enhancing
DTC
detection
shed
light
importance
monitoring
both
prognosis
assessment.
Micromachines,
Год журнала:
2025,
Номер
16(3), С. 332 - 332
Опубликована: Март 13, 2025
To
address
the
issues
of
agglomeration
during
magnetic
particle
capture
and
incomplete
release
these
particles
reuse
in
microfluidic
chips
for
library
preparation,
a
microchamber
was
utilized
to
enhance
dispersion
area
capture.
Additionally,
achieved
through
synergistic
action
flow
field
field.
The
simulation
results
indicated
that
as
inlet
velocity
varied
from
0.02
m/s
0.16
magnet
spacing
ranged
1.2
mm
1.8
mm,
coverage
increased
17.29%
63.59%.
Meanwhile,
rate
decreased
100%
35.2%.
These
processes
were
further
validated
experimental
methods.
During
process,
trajectory
under
effect
aligned
with
expectations.
captured
released
within
12
s,
achieving
100%.
