Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

Chemical Reviews, Год журнала: 2024, Номер 124(7), С. 4124 - 4257

Опубликована: Март 21, 2024

Hydrogen sulfide (H2S) is not only a well-established toxic gas but also an important small molecule bioregulator in all kingdoms of life. In contemporary biology, H2S often classified as "gasotransmitter," meaning that it endogenously produced membrane permeable carries out essential cellular processes. Fluorescent probes for and related reactive sulfur species (RSS) detection provide cornerstone investigating the multifaceted roles these molecules complex biological systems. A now common approach to develop such tools "activity-based probes" couple specific H2S-mediated chemical reaction fluorescent output. This Review covers different types highlights mechanisms by which each probe type activated RSS. Common examples include reduction oxidized nitrogen motifs, disulfide exchange, electrophilic reactions, metal precipitation, coordination. addition, we outline complementary activity-based imaging reductant-labile sulfane species, including persulfides polysulfides. For highlighted this Review, focus on systems with demonstrated compatibility or applications. Building from breadth reported strategies application, highlight key unmet challenges future opportunities advancing

Язык: Английский

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Dual-channel fluorescent probe for simultaneously detecting H2S and viscosity/polarity and its application in non-alcoholic fatty liver, tumor tissue, and food spoilage

Sensors and Actuators B Chemical, Год журнала: 2023, Номер 397, С. 134596 - 134596

Опубликована: Сен. 9, 2023

Язык: Английский

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Advances in fluorescent probe development for bioimaging of potential Parkinson's biomarkers

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 267, С. 116195 - 116195

Опубликована: Янв. 29, 2024

Язык: Английский

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A fluorescent probe for detecting H2O2 and delivering H2S in lysosomes and its application in maintaining the redox environments

Talanta, Год журнала: 2024, Номер 273, С. 125894 - 125894

Опубликована: Март 8, 2024

Язык: Английский

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A turn-on fluorescent probe based on benzothiazole for H2S detection and its multiple applications in water samples and food spoilage

Journal of Molecular Structure, Год журнала: 2024, Номер 1307, С. 137978 - 137978

Опубликована: Март 6, 2024

Язык: Английский

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Unveiling the negative correlation of formaldehyde and hydrogen sulfide in Parkinson’s disease models using a dual-responsive ruthenium(II) complex probe

Chemical Engineering Journal, Год журнала: 2024, Номер 486, С. 150349 - 150349

Опубликована: Март 12, 2024

Язык: Английский

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Responsive β-Diketonate-europium(III) Complex-Based Probe for Time-Gated Luminescence Detection and Imaging of Hydrogen Sulfide In Vitro and In Vivo

Inorganic Chemistry, Год журнала: 2024, Номер 63(29), С. 13244 - 13252

Опубликована: Июль 9, 2024

As a crucial biological gasotransmitter, hydrogen sulfide (H

Язык: Английский

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An innovative near-infrared fluorescent probe designed to track the evolution of carboxylesterase in drug-induced liver injury

Sensors and Actuators B Chemical, Год журнала: 2023, Номер 402, С. 135133 - 135133

Опубликована: Дек. 12, 2023

Язык: Английский

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Peroxynitrite imaging in ferroptosis-mediated drug-induced liver injury with a near-infrared fluorescence probe

Analytica Chimica Acta, Год журнала: 2024, Номер 1309, С. 342673 - 342673

Опубликована: Май 5, 2024

Язык: Английский

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Silica Nanoparticle-Based FRET System for Hydrogen Sulfide Detection in Biological and Food Samples

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(10), С. 11739 - 11748

Опубликована: Май 15, 2024

Hydrogen sulfide (H2S), a crucial endogenous gasotransmitter, plays significant role in monitoring pathological and physiological processes as well the realm of food safety control. The detection H2S poses numerous challenges due to complexity biological fluids samples high demands for biocompatible probe molecules. To address these challenges, we have developed an innovative silica nanoparticle-based Förster resonance energy transfer (FRET) system with pyrene (Py) pyronine (Pyr) embedded donors acceptors (Pyr@Py-SiO2 NPs). This not only enhances biocompatibility fluorescent probes but also effectively mitigates interference from complex through its dual-mode FRET response. Our study reveals that units within nanoparticles facilitate efficient transfer, enabling both colorimetric ratiometric optical H2S. approach is highly sensitive (detection limit 71.5 nM), rapid (response time ≤10 s), uninfluenced by common anions thiols. Moreover, successfully applied this various practical scenarios, including human urine, onion slices, spoilage. work provides effective method systems real-world samples.

Язык: Английский

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