Using Machine Learning to Design a FeMOF Bidirectional Regulator for Electrochemiluminescence Sensing of Tau Protein
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
The
single-luminophore-based
ratiometric
electrochemiluminescence
(ECL)
sensor
coupling
bidirectional
regulator
has
become
a
research
hotspot
in
the
detection
field
because
of
its
simplicity
and
accuracy.
However,
limited
hinders
further
development.
In
this
study,
by
leveraging
robust
predictive
capabilities
machine
learning,
we
prepared
an
Fe-based
metal-organic
framework
(FeMOF)
as
for
modulating
dual-emission
ECL
signals
single
luminophore
first
time.
proof
concept
was
demonstrated
applying
FeMOF
to
classical
Ru(bpy)32+,
results
showed
ability
enhance
cathode
signal
(Ecathode)
inhibit
anode
(Eanode).
As
example,
Tau
protein
(Tau)
utilizing
FeMOF/Ru(bpy)32+
system
developed.
incorporation
effectively
mitigated
erratic
fluctuations
or
minor
discrepancies
between
two
stronger
correlation
stability
Ecathode/Eanode
than
before
regulation.
result,
good
analytical
performance
with
limit
low
3.38
fg
mL-1
(S/N
=
3).
Moreover,
it
not
only
comparable
test
commercially
available
ELISA
kit
but
also
could
well
distinguish
normal
Alzheimer's
disease
(AD)
patients
(80%
specificity
90%
sensitivity).
Thus,
proposed
strategy
is
promising
be
extended
other
luminophores
MOFs,
providing
new
path
sensors.
Язык: Английский
Electrochemiluminescence Mechanisms and Bioanalysis Based on Multishape Gold Nanoparticles and Visualized ATT-Au NCs
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
Herein,
a
visual
electrochemiluminescence
(ECL)
luminophore,
6-azido-2-thioxanthine-coated
gold
nanoclusters
(ATT-Au
NCs),
was
prepared
efficiently
in
single
step,
followed
by
comprehensive
characterization
of
their
structural,
optical,
and
ECL
properties
using
diverse
analytical
methodologies.
Concurrently,
nanoparticles,
dimers,
nanorod
(Au
NR)
dispersions,
dimers
(parallel
perpendicular
conformations)
were
synthesized
via
chemical
reduction,
DNA
ligation,
seed
growth,
electrostatic
adsorption
organic
ligands,
respectively.
The
finite
difference
time
domain
(FDTD)
modeling
subsequently
employed
to
analyze
the
electromagnetic
field
distribution
surrounding
these
revealing
that
parallel
notably
enhanced
intensity.
Based
on
this,
we
constructed
novel
biosensor
harnessed
surface-plasmon-coupled
(SPC-ECL)
resonance
energy
transfer
(RET)
between
ATT-Au
NCs
Au
NR
dimers.
sensor
incorporated
Cu2O
nanoparticles
(NPs)
as
quenching
probes
precisely
induce
RET,
leading
signal
being
switched
"off".
This
dual
enhancement
strategy
achieved
high
signal-to-noise
ratio,
facilitating
sensitive
detection
microRNA-21
(miRNA-21)
with
linear
range
1
fM–100
nM
low
limit
0.28
fM.
work
not
only
extends
our
understanding
SPC
effect
application
RET
mechanism
ECL,
providing
theoretical
foundation
for
further
advancements
field,
but
also
highlights
its
considerable
potential
applications
biomedical
research
clinical
diagnostics.
Язык: Английский
Intramolecular charge transfer synergistic LSPR effect enhanced electrochemiluminescence platform for deoxynivalenol detection
Sensors and Actuators B Chemical,
Год журнала:
2025,
Номер
431, С. 137432 - 137432
Опубликована: Фев. 16, 2025
Язык: Английский
Recent advances in electrochemiluminescence immunosensing
Sensors & Diagnostics,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Herein,
we
review
the
recent
developments
and
applications
of
ECL
for
immunosensing
in
different
areas,
such
as
detection
biomarkers,
bead-based
bacteria
cell
analysis,
provide
future
perspectives
new
developments.
Язык: Английский
Multi-element transition metal electrochemiluminescence system based on efficient quenching strategy for sensitive detection of glial fibrillary acidic protein
Fangqin Han,
Chunfang Cheng,
Jingyu Zhao
и другие.
Sensors and Actuators B Chemical,
Год журнала:
2025,
Номер
unknown, С. 137767 - 137767
Опубликована: Апрель 1, 2025
Язык: Английский
Enzyme- and Nanozyme-Based food allergen detections: from natural biocatalysts to rational engineering approaches
Trends in Food Science & Technology,
Год журнала:
2025,
Номер
unknown, С. 105016 - 105016
Опубликована: Апрель 1, 2025
Язык: Английский
A novel MCI-ECL dual organic ligand MOFs with low-potential by band gap regulation for ultrasensitive S.aureus detection
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 162433 - 162433
Опубликована: Апрель 1, 2025
Язык: Английский
Efficient Al–H3NTB-MOG ECL Emitter with Self-Enhanced and AIECL Performance for Ultrasensitive Sensing of miRNA-141 Combined with a Y-Shaped Multiregion Dual-Drive DNA Walker
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 16, 2025
In
this
work,
using
Al-H3NTB-MOG
with
self-enhanced
and
aggregation-induced
electrochemiluminescence
(AIECL)
performance
as
an
efficient
emitter,
a
biosensor
based
on
Y-shaped
multiregion
dual-drive
DNA
walker
was
constructed
for
the
sensitive
detection
of
miRNA-141.
Notably,
4,4',4″-nitrilotribenzoic
acid
(H3NTB)
selected
luminescent
ligand
ECL
property
co-reactive
tertiary
amine
in
its
structure.
Al3+
served
central
ion
to
coordinate
H3NTB
form
three-dimensional
porous
gel
structure,
which
restricted
internal
rotation
vibration
benzene
molecules
exhibited
excellent
AIECL
property.
More
interestingly,
N-2-hydroxyethylpiperazine-N'-ethane-sulfonic
(HEPES)
chosen
system
buffer,
could
not
only
stabilize
test
environment
but
also
play
co-reaction
compensation
role
compensate
consumption
groups
process,
then
significantly
resulting
better
stability
response.
Besides,
dynamic
signal
amplification
established
synergistic
effect
rolling
cycle
(RCA)
process
ionic
cleavage
at
both
ends
nanostructure
assembled
by
catalytic
hairpin
self-assembly
(CHA)
reaction.
Specifically,
two
long
chains
abundant
recognition
regions
were
formed
RCA
reaction
walker,
simultaneously
walk
along
predesigned
tracks
shear
specific
sites
from
directions,
effectively
improving
efficiency.
that
way,
realized
miRNA-141
10
aM
1
nM
range
limit
low
6.48
aM.
Язык: Английский
Dual-signal immunosensor based on aggregation-induced electrochemiluminescence resonance energy transfer of La-MOF and low cathodic excitation potential of g-C3N4@AuNPs for the quantitation of human serum amyloid A
Sensors and Actuators B Chemical,
Год журнала:
2024,
Номер
424, С. 136925 - 136925
Опубликована: Ноя. 12, 2024
Язык: Английский