Dual-signal immunosensor based on aggregation-induced electrochemiluminescence resonance energy transfer of La-MOF and low cathodic excitation potential of g-C3N4@AuNPs for the quantitation of human serum amyloid A DOI

Shenglan Hu,

Lixin Xu,

M. J. Huang

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 424, P. 136925 - 136925

Published: Nov. 12, 2024

Language: Английский

Using Machine Learning to Design a FeMOF Bidirectional Regulator for Electrochemiluminescence Sensing of Tau Protein DOI
Wei Yuan, Tao Qin, Xuyuan Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

The single-luminophore-based ratiometric electrochemiluminescence (ECL) sensor coupling bidirectional regulator has become a research hotspot in the detection field because of its simplicity and accuracy. However, limited hinders further development. In this study, by leveraging robust predictive capabilities machine learning, we prepared an Fe-based metal-organic framework (FeMOF) as for modulating dual-emission ECL signals single luminophore first time. proof concept was demonstrated applying FeMOF to classical Ru(bpy)32+, results showed ability enhance cathode signal (Ecathode) inhibit anode (Eanode). As example, Tau protein (Tau) utilizing FeMOF/Ru(bpy)32+ system developed. incorporation effectively mitigated erratic fluctuations or minor discrepancies between two stronger correlation stability Ecathode/Eanode than before regulation. result, good analytical performance with limit low 3.38 fg mL-1 (S/N = 3). Moreover, it not only comparable test commercially available ELISA kit but also could well distinguish normal Alzheimer's disease (AD) patients (80% specificity 90% sensitivity). Thus, proposed strategy is promising be extended other luminophores MOFs, providing new path sensors.

Language: Английский

Citations

1
Electrochemiluminescence Mechanisms and Bioanalysis Based on Multishape Gold Nanoparticles and Visualized ATT-Au NCs DOI
Yan Liu, Jia Zhang,

Jia-Wan Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Herein, a visual electrochemiluminescence (ECL) luminophore, 6-azido-2-thioxanthine-coated gold nanoclusters (ATT-Au NCs), was prepared efficiently in single step, followed by comprehensive characterization of their structural, optical, and ECL properties using diverse analytical methodologies. Concurrently, nanoparticles, dimers, nanorod (Au NR) dispersions, dimers (parallel perpendicular conformations) were synthesized via chemical reduction, DNA ligation, seed growth, electrostatic adsorption organic ligands, respectively. The finite difference time domain (FDTD) modeling subsequently employed to analyze the electromagnetic field distribution surrounding these revealing that parallel notably enhanced intensity. Based on this, we constructed novel biosensor harnessed surface-plasmon-coupled (SPC-ECL) resonance energy transfer (RET) between ATT-Au NCs Au NR dimers. sensor incorporated Cu2O nanoparticles (NPs) as quenching probes precisely induce RET, leading signal being switched "off". This dual enhancement strategy achieved high signal-to-noise ratio, facilitating sensitive detection microRNA-21 (miRNA-21) with linear range 1 fM–100 nM low limit 0.28 fM. work not only extends our understanding SPC effect application RET mechanism ECL, providing theoretical foundation for further advancements field, but also highlights its considerable potential applications biomedical research clinical diagnostics.

Language: Английский

Citations

1
Intramolecular charge transfer synergistic LSPR effect enhanced electrochemiluminescence platform for deoxynivalenol detection DOI
Xiang Mei,

Shan Yao,

Lihui Xu

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: 431, P. 137432 - 137432

Published: Feb. 16, 2025

Language: Английский

Citations

1
Recent advances in electrochemiluminescence immunosensing DOI Creative Commons
Jing Yu, Dalibor M. Stanković, Jasmina Vidić

et al.

Sensors & Diagnostics, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Herein, we review the recent developments and applications of ECL for immunosensing in different areas, such as detection biomarkers, bead-based bacteria cell analysis, provide future perspectives new developments.

Language: Английский

Citations

6
Multi-element transition metal electrochemiluminescence system based on efficient quenching strategy for sensitive detection of glial fibrillary acidic protein DOI

Fangqin Han,

Chunfang Cheng,

Jingyu Zhao

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137767 - 137767

Published: April 1, 2025

Language: Английский

Citations

0
Enzyme- and Nanozyme-Based food allergen detections: from natural biocatalysts to rational engineering approaches DOI Creative Commons
Shuang Wu, Jinlong Zhao, Youfa Wang

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 105016 - 105016

Published: April 1, 2025

Language: Английский

Citations

0
A novel MCI-ECL dual organic ligand MOFs with low-potential by band gap regulation for ultrasensitive S.aureus detection DOI
Xuemei Wang,

Zhiyong Yan,

Feifei Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162433 - 162433

Published: April 1, 2025

Language: Английский

Citations

0
Efficient Al–H3NTB-MOG ECL Emitter with Self-Enhanced and AIECL Performance for Ultrasensitive Sensing of miRNA-141 Combined with a Y-Shaped Multiregion Dual-Drive DNA Walker DOI
Jiping Yang, Li Wang, Yifei Chen

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

In this work, using Al-H3NTB-MOG with self-enhanced and aggregation-induced electrochemiluminescence (AIECL) performance as an efficient emitter, a biosensor based on Y-shaped multiregion dual-drive DNA walker was constructed for the sensitive detection of miRNA-141. Notably, 4,4',4″-nitrilotribenzoic acid (H3NTB) selected luminescent ligand ECL property co-reactive tertiary amine in its structure. Al3+ served central ion to coordinate H3NTB form three-dimensional porous gel structure, which restricted internal rotation vibration benzene molecules exhibited excellent AIECL property. More interestingly, N-2-hydroxyethylpiperazine-N'-ethane-sulfonic (HEPES) chosen system buffer, could not only stabilize test environment but also play co-reaction compensation role compensate consumption groups process, then significantly resulting better stability response. Besides, dynamic signal amplification established synergistic effect rolling cycle (RCA) process ionic cleavage at both ends nanostructure assembled by catalytic hairpin self-assembly (CHA) reaction. Specifically, two long chains abundant recognition regions were formed RCA reaction walker, simultaneously walk along predesigned tracks shear specific sites from directions, effectively improving efficiency. that way, realized miRNA-141 10 aM 1 nM range limit low 6.48 aM.

Language: Английский

Citations

0
Dual-signal immunosensor based on aggregation-induced electrochemiluminescence resonance energy transfer of La-MOF and low cathodic excitation potential of g-C3N4@AuNPs for the quantitation of human serum amyloid A DOI

Shenglan Hu,

Lixin Xu,

M. J. Huang

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 424, P. 136925 - 136925

Published: Nov. 12, 2024

Language: Английский

Citations

1