Interdisciplinary Sciences Computational Life Sciences, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 178, С. 113958 - 113958
Опубликована: Сен. 1, 2021
Язык: Английский
Процитировано
248
ACS Nano, Год журнала: 2021, Номер 15(12), С. 18653 - 18660
Опубликована: Дек. 3, 2021
Gut microbiota dynamically participate in diverse physiological activities with direct impact on the host's health. A range of factors associated highly complex intestinal flora ecosystem poses challenges regulating homeostasis microbiota. The consumption live probiotic bacteria, principle, can address these and confer health benefits. In this context, one major problems is ensuring survival cells when faced physical chemical assaults during their intake subsequent gastrointestinal passage to gut. Advances field have focused improving conventional encapsulation techniques microscale achieve high cell viability, gastric temperature resistance, longer shelf lives. However, microencapsulation approaches are known limitations possible difficulties clinical translation. Perspective, we present a brief overview current progress different methods highlight contemporary emerging single-cell strategies using nanocoatings for individual cells. Finally, discuss relative advantages various nanoencapsulation future trend toward developing coated probiotics advanced features
Язык: Английский
Процитировано
127
Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 182, С. 114098 - 114098
Опубликована: Янв. 5, 2022
Язык: Английский
Процитировано
127
Journal of Controlled Release, Год журнала: 2021, Номер 337, С. 530 - 545
Опубликована: Июль 30, 2021
Язык: Английский
Процитировано
122
Journal of Controlled Release, Год журнала: 2022, Номер 353, С. 1107 - 1126
Опубликована: Дек. 25, 2022
Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential enhance bioavailability whilst reducing off-target effects. Delivering drugs colon requires considered formulation development, as both oral rectal dosage forms encounter challenges if colon's distinct physiological environment is not appreciated. As opportunities surrounding colonic multiply, success of novel pharmaceuticals lies in their design. This review provides a modern insight into key parameters determining effective design development colon-targeted medicines. Influential features governing release, dissolution, stability, absorption are first discussed, followed by an overview most reliable strategies. Finally, appropriate vitro, vivo, silico preclinical investigations presented, with goal inspiring strategic new therapeutics.
Язык: Английский
Процитировано
110
Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Окт. 9, 2023
Abstract Individual variability in drug response (IVDR) can be a major cause of adverse reactions (ADRs) and prolonged therapy, resulting substantial health economic burden. Despite extensive research pharmacogenomics regarding the impact individual genetic background on pharmacokinetics (PK) pharmacodynamics (PD), diversity explains only limited proportion IVDR. The role gut microbiota, also known as second genome, its metabolites modulating therapeutic outcomes human diseases have been highlighted by recent studies. Consequently, burgeoning field pharmacomicrobiomics aims to explore correlation between microbiota variation IVDR or ADRs. This review presents an up-to-date overview intricate interactions classical agents for systemic diseases, including cancer, cardiovascular (CVDs), endocrine others. We summarise how directly indirectly, modify absorption, distribution, metabolism, excretion (ADME) drugs. Conversely, drugs modulate composition function leading changes microbial metabolism immune response. discuss practical challenges, strategies, opportunities this field, emphasizing critical need develop innovative approach multi-omics, integrate various data types, genomic data, well translate lab into clinical practice. To sum up, represents promising avenue address improve patient outcomes, further is imperative unlock full potential precision medicine.
Язык: Английский
Процитировано
80
Nature Aging, Год журнала: 2023, Номер 3(4), С. 436 - 449
Опубликована: Апрель 6, 2023
Язык: Английский
Процитировано
79
Ageing Research Reviews, Год журнала: 2023, Номер 90, С. 102013 - 102013
Опубликована: Июль 8, 2023
Язык: Английский
Процитировано
54
Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 181, С. 114076 - 114076
Опубликована: Дек. 8, 2021
Язык: Английский
Процитировано
101
Advances in Nutrition, Год журнала: 2022, Номер 13(5), С. 1450 - 1461
Опубликована: Июль 1, 2022
Humans often show variable responses to dietary, prebiotic, and probiotic interventions. Emerging evidence indicates that the gut microbiota is a key determinant for this population heterogeneity. Here, we provide an overview of some major computational experimental tools being applied critical questions microbiota-mediated personalized nutrition health. First, discuss latest advances in silico modeling microbiota-nutrition-health axis, including application statistical, mechanistic, hybrid artificial intelligence models. Second, address high-throughput vitro techniques assessing interindividual heterogeneity, from ex vivo batch culturing stool continuous anaerobic bioreactors, more sophisticated organ-on-a-chip models integrate both host microbial compartments. Third, explore approaches better understanding personalized, diet, prebiotics, probiotics, nonhuman animal human observational studies, feeding trials crossover We highlight examples existing, consumer-facing precision platforms are currently leveraging microbiota. Furthermore, how integration broader set described piece can generate data necessary support greater diversity strategies. Finally, present vision healthcare future, which leverages design effective, individual-specific
Язык: Английский
Процитировано
44