Abstract
Background
The
use
of
plant
extracts
as
antibiotics
is
gaining
more
attention
because
bacteria
are
one
the
biggest
threats
to
global
health
and
resistance
in
humans
animals
increasing.
Antibacterial
susceptibility
used
determine
which
specific
a
particular
bacterium
sensitive
to.
This
research
focused
on
phytochemical,
vitro
antibacterial
susceptibility,
silico
analysis
Morinda
lucida
root
against
gram-negative
Pseudomonas
aeruginosa
gram-positive
Staphylococcus
aureus
.
M.
was
extracted
separately
with
ethanol,
chloroform,
ethyl
acetate.
Results
Crude
had
active
activity
were
promising
natural
antibiotic
when
compared
gentamicin.
results
showed
that
good
properties
two
drug-resistant
while
2-hydroxy-1-methoxy
anthraquinone
predicted
have
better
S.
alizarin
has
P.
aeruginosa.
Finally,
MD
simulation
studies
Alizarin
9,10-Anthracenedione
2-hydroxy-1-
methoxy-
define
stability
protein–ligand
complexes
within
50
ns
time
scale.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2191 - 2191
Опубликована: Янв. 22, 2023
Natural
hydrogels
are
widely
used
as
biomedical
materials
in
many
areas,
including
drug
delivery,
tissue
scaffolds,
and
particularly
wound
dressings,
where
they
can
act
an
antimicrobial
factor
lowering
the
risk
of
microbial
infections,
which
serious
health
problems,
especially
with
respect
to
healing.
In
this
review
article,
a
number
promising
strategies
development
biocidal
properties,
those
originating
from
natural
polymers,
briefly
summarized
concisely
discussed.
Common
design
fabricate
intrinsic
or
stimuli-triggered
antibacterial
activity
exemplified,
mechanisms
lying
behind
these
properties
also
Finally,
practical
applications
considered
while
discussing
current
challenges
perspectives.
Abstract
Bacterial
transmission
is
considered
one
of
the
potential
risks
for
communicable
diseases,
requiring
promising
antibiotics.
Traditional
drugs
possess
a
limited
spectrum
effectiveness,
and
their
frequent
administration
reduces
effectiveness
develops
resistivity.
In
such
situation,
we
are
left
with
option
developing
novel
antibiotics
higher
efficiency.
this
regard,
nanoparticles
(NPs)
may
play
pivotal
role
in
managing
medical
situations
due
to
distinct
physiochemical
characteristics
impressive
biocompatibility.
Metallic
NPs
found
extraordinary
antibacterial
effects
that
useful
vitro
as
well
vivo
self-modified
therapeutic
agents.
Due
wide
range
efficacy,
they
have
applications
via
diverse
routes.
not
only
restrict
development
bacterial
resistance,
but
also
broaden
scope
action
without
binding
cell
directly
particular
receptor
against
both
Gram-positive
Gram-negative
microbes.
This
review
aimed
at
exploring
most
relevant
types
metal
employed
antimicrobial
agents,
particularly
those
based
on
Mn,
Fe,
Co,
Cu,
Zn
metals,
mechanisms.
Further,
challenges
future
prospects
biological
discussed.
Nanomedicine,
Год журнала:
2023,
Номер
18(5), С. 471 - 484
Опубликована: Фев. 1, 2023
Translation
of
antibacterial
nanoparticles
into
nanomedicine
requires
a
deep
understanding
the
dynamic
nature
and
ways
they
overcome
immunological
biological
barriers.
Nanomedicines
need
prolonged
serum
stability
by
proper
stealth
coating
or
forming
beneficial
protein
corona,
to
avoid
rapid
clearance
mononuclear
phagocytic
system.
A
preferred
nanoparticle
formulation
may
include
nonimmunogenic
carbohydrates,
which
act
both
as
ligands
specific
endothelium
receptors
facilitate
nanomedicines
crossing
vascular
barrier.
This
lead
more
delivery
accumulation
at
infection
site
provide
broader
faster
clinical
responses
than
targeting
bacterial
surface
receptors.
Ideally,
should
be
able
penetrate
biofilms
through
fusion
and/or
diffusion
for
targeted
delivery.
Heliyon,
Год журнала:
2023,
Номер
9(4), С. e14985 - e14985
Опубликована: Март 31, 2023
Plants
from
the
Asteraceae
family
are
widely
used
as
ethno
medicines
to
treatment
parasitic,
malaria,
hematemesis,
pruritus,
pyretic,
anthelmintic,
wound
healing.
The
aim
of
this
review
is
provide
an
overview
plants
antimicrobial
activity.
most
relevant
results
published
studies
summarized
and
discussed.
species
in
genus
Artemisia,
Echinacea,
Centaurea,
Baccharis,
Calendula
showed
Most
these
usually
treat
infection,
inflammation,
parasitics.
effective
part
or
component
for
was
essential
oil
crude
extract,
attracted
more
attention.
It
also
reported
that
nanoparticles
coated
with
extract
were
against
multidrug
resistant
bacteria.
For
bacteria
study,
Armtemisia
investigated,
Staphylococcus
aureus
Escherichia
coli
studied
strains.
activity
evaluated
mainly
based
on
minimum
inhibitory
concentration
(MIC).
Few
reports
have
been
bactericide
(MBC)
its
antibacterial
mechanisms.
According
study
results,
some
potential
be
developed
bacteriostatic
agents
However,
still
vitro,
further
clinical
applied
needed.
Advanced Functional Materials,
Год журнала:
2022,
Номер
33(2)
Опубликована: Ноя. 4, 2022
Abstract
Effective
therapy
of
infection
impaired
tissue
defects
has
long
been
an
important
but
challenging
topic,
and
alternative
antibiotic‐free
solutions
are
greatly
demanded
to
tackle
bacterial
infections
promote
repair.
Herein,
the
use
supercharged
gold
nanoclusters
(AuNCs)
with
enhanced
enzyme
mimic
activity
as
novel
interface
modulator
bioactive
glass
nanoparticles
(BGN)
for
infected
wound
treatment
is
reported.
The
AuNCs
exhibit
extraordinary
affinity
toward
BGN,
leading
robust
immobilization
on
BGN
(BGN‐AuNCs).
Functional
endow
superior
peroxidase‐like
catalytic
antibacterial
action,
which
can
kill
bacteria
a
concentration
down
75
µg
mL
−1
within
6
h
due
production
highly
toxic
·OH.
Moreover,
expression
level
COL‐1,
TGF‐β,
FGF‐2
in
fibroblasts
actively
up‐regulated
2.9,
3.1,
1.6
times
higher
than
that
control
group
positive
effect
BGN‐AuNCs
cell
proliferation.
Meanwhile,
intrinsic
photoluminescent
property
enables
direct
visualization
at
both
vitro
vivo
levels
potentially
bioimaging‐guided
therapy.
Further
results
demonstrate
hold
enormous
promise
infectious
disease
pro‐regeneration,
proposed
engineering
strategy
attractive
developing
advanced
functional
nanomedicines.
