Biomedical potentials of alginate via physical, chemical, and biological modifications
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
277, С. 134409 - 134409
Опубликована: Авг. 7, 2024
Язык: Английский
Anti-Aging Effects of Flavonoids from Plant Extracts
Foods,
Год журнала:
2024,
Номер
13(15), С. 2441 - 2441
Опубликована: Авг. 2, 2024
Aging
is
a
natural
and
irreversible
process,
affecting
living
organisms
by
negatively
impacting
the
tissues'
cells'
morphology
functionality
consequently
being
responsible
for
aging-related
diseases.
Taking
into
account
actual
preoccupations
of
both
consumers
researchers,
healthy
anti-aging
alternatives
are
intensively
studied
in
order
to
address
such
concerns.
Due
their
functional
features,
plant
flavonoids
can
be
considered
valuable
nutraceuticals.
This
paper
highlights
possibilities
use
extracted
from
various
plants
potential
on
skin,
brain,
heart.
Moreover,
anticarcinogenic,
anti-inflammatory,
anti-diabetic
properties
summarized,
along
with
senescence-associated
mechanisms.
Both
nutraceutical
cosmeceutical
fields
continuously
developing
originating
promising
candidates
obtain
products.
Thus,
bioactive
compounds'
extraction
subsequent
involvement
innovative
product
manufacturing
must
carefully
performed
while
aware
intrinsic
extrinsic
factors
that
may
affect
phytochemicals'
structures,
bioavailability,
health
effects.
Язык: Английский
Insights into the formation of pullulan nanofilm and its feasibility as probiotic-resided oral fast dissolving carrier
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
299, С. 140091 - 140091
Опубликована: Янв. 20, 2025
Язык: Английский
Evaluating Swellable Cross-Linked Biopolymer Impact on Ink Rheology and Mechanical Properties of Drug-Contained 3D-Printed Thin Film
Farzana Khan Rony,
J. K. Appiah,
Asmaa Alawbali
и другие.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 183 - 183
Опубликована: Фев. 1, 2025
Background/Objectives:
Interest
in
3D
printing
oral
thin
films
(OTFs)
has
increased
substantially.
The
challenge
of
is
film
printability,
which
strongly
affected
by
the
rheological
properties
ink
and
having
suitable
mechanical
properties.
This
research
assesses
suitability
sodium
starch
glycolate
(SSG),
a
swellable
cross-linked
biopolymer,
on
rheology
film’s
Methods:
A
water-based
comprising
alginate
(SA),
drug
fenofibrate
(FNB),
SSG,
glycerin,
polyvinylpyrrolidone
(PVP)
was
formulated,
its
assessed
through
flow,
amplitude
sweeps,
thixotropy
tests.
Films
(10
mm
×
15
0.35
mm)
were
3D-printed
using
410
µm
nozzle,
50%
infill
density,
60
kPa
pressure,
10
mm/s
speed,
with
(Young’s
modulus,
tensile
strength,
elongation
at
break)
analyzed
TA-XT
Plus
C
texture
analyzer.
Results:
showed
SSG-based
(shear-thinning
behavior,
high
viscosity,
higher
quick
recovery)
for
printing.
SSG
enhanced
(viscosity
modulus)
but
not
film.
XRD
DSC
confirmed
preserved
FNB
crystallinity
without
polymorphic
changes.
SEM
images
surface
morphology
particle
distribution
across
demonstrated
loading
44.28%
(RSD
5.62%)
dissolution
rate
~77%
within
30
min.
Conclusions:
improves
rheology,
makes
it
compatible
printing,
enhances
(formulation
F-5).
Plasticizer
glycerin
essential
to
achieve
required
study
confirms
SSG’s
OTFs.
Язык: Английский
Tailored Sticky Solutions: 3D-Printed Miconazole Buccal Films for Pediatric Oral Candidiasis
AAPS PharmSciTech,
Год журнала:
2024,
Номер
25(7)
Опубликована: Авг. 20, 2024
Язык: Английский
Comparative Study of Phytochemical Analysis and Anti-Microbial Activity of <em>Ziziphus spina-christi</em> L. Leaves Extracts From Different Areas in Sudan
Опубликована: Июнь 7, 2024
We
conducted
a
study
exploring
the
potential
of
medicinal
plant
Ziziphus
spina-christi
as
source
antimicrobial
compounds.
With
growing
threat
antibiotic
resistance,
we
were
particularly
interested
in
evaluating
plant-derived
natural
products
for
their
ability
to
fight
infections.
collected
Z.
leaves
from
four
different
regions
Sudan
and
extracted
them
with
ethanol.
Our
phytochemical
screening
revealed
presence
several
secondary
metabolites,
including
flavonoids,
triterpenes,
sterols,
tannins,
saponins,
cardiac
glycosides,
reducing
sugars.
Alkaloids
anthraquinones
not
detected.
then
tested
ethanolic
extracts
activity
against
range
bacterial
fungal
pathogens
using
agar
well
diffusion
method.
Interestingly,
observed
significant
differences
between
locations.
The
extract
Khartoum
city
exhibited
highest
potency,
followed
by
Al-Rahad,
Al-Hidiba,
finally
Al
Damazin.
Based
on
these
findings,
concluded
that
contain
diverse
array
phytochemicals
applications.
variation
effects
may
be
attributed
environmental
factors
influencing
plant's
chemical
composition.
Further
research
is
warranted
identify
specific
bioactive
compounds
responsible
activities.
This
could
pave
way
development
plant-based
agents
combat
drug-resistant
alleviate
global
public
health
crisis
posed
rise
resistance.
Язык: Английский
From Concept to Market: Evaluating the Role of Fast-Dissolving Strips in Oral Drug Delivery
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
unknown, С. 106239 - 106239
Опубликована: Сен. 1, 2024
Язык: Английский
Biocompatible Natural Polymers and Cutting-Edge Fabrication Techniques in the Development of Next-Generation Oral Thin Films for Enhanced Drug Delivery Systems
Current Pharmaceutical Design,
Год журнала:
2024,
Номер
31(5), С. 331 - 343
Опубликована: Окт. 14, 2024
Oral
thin
films
are
changing
the
way
drugs
delivered,
making
drug
administration
more
convenient
and
patient-friendly.
This
review
delves
into
fascinating
possibilities
of
natural
polymers
in
film
design.
We
consider
benefits
biocompatible
produced
from
chitosan,
gelatin,
pullulan.
Their
intrinsic
biodegradability
safety
make
them
excellent
for
use
with
a
wide
range
patients.
Additionally,
research
investigates
novel
strategies
creating
these
distinctive
delivery
systems.
look
beyond
standard
solvent
casting
techniques,
hot
melt
extrusion
methods,
rolling
etc.
These
technologies
provide
exact
control
over
qualities,
allowing
tailored
medication
increased
patient
compliance.
seeks
to
bridge
gap
between
cutting-edge
fabrication
processes.
By
investigating
this
combination,
we
pave
road
development
next-generation
oral
that
efficacious,
patient-acceptable,
environmentally-friendly.
Язык: Английский