BioNanoScience, Год журнала: 2024, Номер 15(1)
Опубликована: Дек. 17, 2024
Язык: Английский
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 14, 2024
Abstract Electrochemical (EC) analysis has emerged as a high‐sensitivity, reliable, cost‐effective, and rapidly evolving technique that garnered significant attention across diverse domains. Furthermore, EC‐based techniques hold great potential for miniaturization integration. The integration of EC with mode/signal (such light, magnetic, thermal signals, etc.) provides unique opportunities biosensors to acquire more information through single sensing platform. By coupling multiple signals or processing them logically, the detection accuracy can be further improved, probability false positives negatives minimized. In this review, thorough multi‐ sensors in field is conducted, along their various (e.g., fluorescence, photothermal, colorimetry, microfluidic, etc.). aim delve into latest advances, applications, well challenges multi‐mode/signal biosensors, where utilization modalities helps enhance accuracy, sensitivity, selectivity. This review new insight synergistic effects integrating other techniques, aiming shed light on near‐future developments EC‐integrated biosensors.
Язык: Английский
Процитировано
24
Talanta, Год журнала: 2024, Номер 279, С. 126544 - 126544
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
11
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 13, 2024
Nanozymes, characterized by their nanoscale size and enzyme-like catalytic activities, exhibit diverse therapeutic potentials, including anti-oxidative, anti-inflammatory, anti-microbial, anti-angiogenic effects. These properties make them highly valuable in nanomedicine, particularly ocular therapy, bypassing the need for systemic delivery. Nanozymes show significant promise tackling multi-factored diseases, those influenced oxidation inflammation, like dry eye disease, age-related macular degeneration. Their small size, coupled with ease of modification integration into soft materials, facilitates effective penetration barriers, thereby enabling targeted or prolonged therapy within eye. This review is dedicated to exploring diseases that are intricately linked shedding light on role nanozymes managing these conditions. Additionally, recent studies elucidating advanced applications therapeutics, along materials disease management, discussed. Finally, this outlines directions future investigations aimed at bridging gap between nanozyme research clinical applications.
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139704 - 139704
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113093 - 113093
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Talanta, Год журнала: 2025, Номер unknown, С. 127957 - 127957
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 17, 2025
Traditional methods for synthesizing nanozymes are often time-consuming and complex, hindering efficiency. Artificial intelligence (AI) has the potential to simplify these processes, but there very few dedicated nanozyme databases available, limiting resources research application. To address this gap, we developed AI-ZYMES, a comprehensive database featuring 1,085 entries 400 types of nanozymes. The platform incorporates several key innovations that distinguish it from existing databases: Firstly, standardized Data Curation: AI-ZYMES resolves inconsistencies in catalytic metrics (e.g., Km, Vmax), morphologies, dispersion systems, enabling reliable cross-study comparisons, something like DiZyme nanozymes.net lack.Secondly, dual AI Framework: A gradient-boosting regressor predicts kinetic constants (Km, Vmax, Kcat) with an R2 up 0.85, while AdaBoost classifier identifies enzyme-mimicking activities based solely on names, surpassing traditional random forest models predictive accuracy.Lastly, ChatGPT-based Synthesis Assistant: includes AI-driven assistant literature extraction (67.55% accuracy) synthesis pathway generation via semantic analysis (90% accuracy). This reduces manual effort minimizes errors large language model outputs, ensuring high-quality results.These make valuable tool accelerating application, including antimicrobial therapy, biosensing, environmental remediation. improves data accessibility, experimental redundancy, speeds translation discoveries into practical use. By bridging fragmentation limitations establishes new benchmark advancements nanomaterials.
Язык: Английский
Процитировано
0
Biomedical Journal, Год журнала: 2024, Номер 47(4), С. 100773 - 100773
Опубликована: Июль 24, 2024
This issue of the Biomedical Journal highlights major advancements in drug delivery, including aptamer-functionalized liposomes and nanozymes. A new biomarker combination shows promise for improved diagnosis idiopathic pulmonary fibrosis. Mesenchymal stem cells are suggested to mitigate inflammation systemic lupus erythematosus, a potential positive feedback loop driven by prevalent mRNA modification is enhance NSCLC progression. Additional articles explore pathological impact on autophagy leading muscle dysfunction, benefits integrating an orphan with standard therapy glioblastoma patients, influence transcriptional super-enhancers early-stage esophageal squamous cell carcinoma. Finally, this provides insights into roles different Blastocystis subtypes, use laser light treating infantile hemangioma.
Язык: Английский
Процитировано
0
BioNanoScience, Год журнала: 2024, Номер 15(1)
Опубликована: Дек. 17, 2024
Язык: Английский
Процитировано
0