The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 859 - 859
Опубликована: Фев. 28, 2025
Ultra-processed
foods
(UPFs)
have
become
a
widely
consumed
food
category
in
modern
diets.
However,
their
impact
on
gut
health
is
raising
increasing
concerns.
This
review
investigates
how
UPFs
the
microbiome
and
barrier,
emphasizing
dysbiosis
increased
permeability.
UPFs,
characterized
by
high
content
of
synthetic
additives
emulsifiers,
low
fiber
content,
are
associated
with
decrease
microbial
diversity,
lower
levels
beneficial
bacteria
like
Akkermansia
muciniphila
Faecalibacterium
prausnitzii,
an
increase
pro-inflammatory
microorganisms.
These
alterations
community
contribute
to
persistent
inflammation,
which
various
chronic
disorders
including
metabolic
syndrome,
irritable
bowel
type
2
diabetes,
colorectal
cancer.
In
addition,
may
alter
gut-brain
axis,
potentially
affecting
cognitive
function
mental
health.
Dietary
modifications
incorporating
fiber,
fermented
foods,
probiotics
can
help
mitigate
effects
UPFs.
Furthermore,
public
needs
stricter
regulations
for
banning
along
well-defined
labels.
Further
studies
necessary
elucidate
mechanisms
connecting
systemic
illnesses,
thereby
informing
evidence-based
dietary
guidelines.
Язык: Английский
Gut microbiota therapy in gastrointestinal diseases
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 26, 2025
The
human
gut
microbiota,
consisting
of
trillions
microorganisms,
plays
a
crucial
role
in
gastrointestinal
(GI)
health
and
disease.
Dysbiosis,
an
imbalance
microbial
composition,
has
been
linked
to
range
GI
disorders,
including
inflammatory
bowel
disease
(IBD),
irritable
syndrome
(IBS),
celiac
disease,
colorectal
cancer.
These
conditions
are
influenced
by
the
interactions
between
host
immune
system,
gut-brain
axis.
Recent
research
highlighted
potential
for
microbiome-based
therapeutic
strategies,
such
as
probiotics,
prebiotics,
fecal
microbiota
transplantation
(FMT),
dietary
modifications,
restore
balance
alleviate
symptoms.
This
review
examines
pathogenesis
common
diseases
explores
emerging
approaches
aimed
at
modulating
microbiome.
We
discuss
scientific
foundations
these
interventions,
their
clinical
effectiveness,
challenges
implementation.
underscores
microbiome-targeted
treatments
novel
approach
managing
offering
personalized
alternative
options
conventional
therapies.
As
this
field
continues
evolve,
interventions
hold
promise
improving
treatment
prevention
diseases.
Язык: Английский
Confrontation of the ambivalent roles of the intestinal microbiota in carcinogenesis: Oncogenic or anticancer agents?
Journal Of Advanced Pharmacy Education And Research,
Год журнала:
2025,
Номер
15(2), С. 16 - 30
Опубликована: Янв. 1, 2025
Язык: Английский
Plant Terpenoids in Combination with Conventional Therapeutics in Colorectal Cancer: A Promising Option
Current Oncology Reports,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Язык: Английский
Progress on the mechanism of intestinal microbiota against colorectal cancer
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 28, 2025
The
intestinal
microbiota
plays
a
crucial
role
in
the
occurrence
and
development
of
colorectal
cancer,
its
anti
-
cancer
mechanism
has
become
research
hotspot.
This
article
comprehensively
expounds
on
molecular
mechanisms
including
aspects
such
as
immune
regulation,
activation
carcinogenic
signaling
pathways
(it
should
be
noted
that
it
is
more
reasonable
to
“inhibition
pathways”),
metabolite
mediated
effects,
maintenance
barrier
function.
At
same
time,
explores
roles
potential
intervention
methods
probiotic
supplementation
therapy,
immunotherapy,
fecal
transplantation.
In
addition,
analyzes
impact
flora
therapeutic
efficacy
cancer.
existing
results
are
summarized,
future
directions
prospected,
with
aim
providing
new
theoretical
bases
treatment
ideas
for
prevention
Язык: Английский