Progress on the mechanism of intestinal microbiota against colorectal cancer DOI Creative Commons
Guoqiang Xing,

Yu Cui,

Zhiyue Guo

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 28, 2025

The intestinal microbiota plays a crucial role in the occurrence and development of colorectal cancer, its anti - cancer mechanism has become research hotspot. This article comprehensively expounds on molecular mechanisms including aspects such as immune regulation, activation carcinogenic signaling pathways (it should be noted that it is more reasonable to “inhibition pathways”), metabolite mediated effects, maintenance barrier function. At same time, explores roles potential intervention methods probiotic supplementation therapy, immunotherapy, fecal transplantation. In addition, analyzes impact flora therapeutic efficacy cancer. existing results are summarized, future directions prospected, with aim providing new theoretical bases treatment ideas for prevention

Language: Английский

The Detrimental Impact of Ultra-Processed Foods on the Human Gut Microbiome and Gut Barrier DOI Open Access
D. Rondinella, Pauline Raoul,

Eleonora Valeriani

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 859 - 859

Published: Feb. 28, 2025

Ultra-processed foods (UPFs) have become a widely consumed food category in modern diets. However, their impact on gut health is raising increasing concerns. This review investigates how UPFs the microbiome and barrier, emphasizing dysbiosis increased permeability. UPFs, characterized by high content of synthetic additives emulsifiers, low fiber content, are associated with decrease microbial diversity, lower levels beneficial bacteria like Akkermansia muciniphila Faecalibacterium prausnitzii, an increase pro-inflammatory microorganisms. These alterations community contribute to persistent inflammation, which various chronic disorders including metabolic syndrome, irritable bowel type 2 diabetes, colorectal cancer. In addition, may alter gut-brain axis, potentially affecting cognitive function mental health. Dietary modifications incorporating fiber, fermented foods, probiotics can help mitigate effects UPFs. Furthermore, public needs stricter regulations for banning along well-defined labels. Further studies necessary elucidate mechanisms connecting systemic illnesses, thereby informing evidence-based dietary guidelines.

Language: Английский

Citations

2
Gut microbiota therapy in gastrointestinal diseases DOI Creative Commons
Hanif Ullah, Safia Arbab, Chengting Chang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 26, 2025

The human gut microbiota, consisting of trillions microorganisms, plays a crucial role in gastrointestinal (GI) health and disease. Dysbiosis, an imbalance microbial composition, has been linked to range GI disorders, including inflammatory bowel disease (IBD), irritable syndrome (IBS), celiac disease, colorectal cancer. These conditions are influenced by the interactions between host immune system, gut-brain axis. Recent research highlighted potential for microbiome-based therapeutic strategies, such as probiotics, prebiotics, fecal microbiota transplantation (FMT), dietary modifications, restore balance alleviate symptoms. This review examines pathogenesis common diseases explores emerging approaches aimed at modulating microbiome. We discuss scientific foundations these interventions, their clinical effectiveness, challenges implementation. underscores microbiome-targeted treatments novel approach managing offering personalized alternative options conventional therapies. As this field continues evolve, interventions hold promise improving treatment prevention diseases.

Language: Английский

Citations

0
Confrontation of the ambivalent roles of the intestinal microbiota in carcinogenesis: Oncogenic or anticancer agents? DOI
Fatouma Mohamed Abdoul‐Latif, Ayoub Ainane,

Omaima Saoudi

et al.

Journal Of Advanced Pharmacy Education And Research, Journal Year: 2025, Volume and Issue: 15(2), P. 16 - 30

Published: Jan. 1, 2025

Language: Английский

Citations

0
Plant Terpenoids in Combination with Conventional Therapeutics in Colorectal Cancer: A Promising Option DOI
Chengu Niu, Jing Zhang, Patrick Okolo

et al.

Current Oncology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

Citations

0
Progress on the mechanism of intestinal microbiota against colorectal cancer DOI Creative Commons
Guoqiang Xing,

Yu Cui,

Zhiyue Guo

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 28, 2025

The intestinal microbiota plays a crucial role in the occurrence and development of colorectal cancer, its anti - cancer mechanism has become research hotspot. This article comprehensively expounds on molecular mechanisms including aspects such as immune regulation, activation carcinogenic signaling pathways (it should be noted that it is more reasonable to “inhibition pathways”), metabolite mediated effects, maintenance barrier function. At same time, explores roles potential intervention methods probiotic supplementation therapy, immunotherapy, fecal transplantation. In addition, analyzes impact flora therapeutic efficacy cancer. existing results are summarized, future directions prospected, with aim providing new theoretical bases treatment ideas for prevention

Language: Английский

Citations

0