Investigating the metabolomic pathways in female reproductive endocrine disorders: a Mendelian randomization study DOI Creative Commons

Feifan Lu,

Zheng Wang, Qianqian Yang

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Окт. 31, 2024

Reproductive endocrine disorders (RED), including polycystic ovary syndrome (PCOS), endometriosis (EMs), and female infertility (FI), significantly affect women's health globally, with varying prevalence across different regions. These conditions can be addressed through medication, surgical interventions, lifestyle modifications. However, the limited understanding of RED's etiology substantial economic burden its treatment highlight importance investigating pathogenesis. Metabolites play a critical role in metabolic processes are potentially linked to development RED. Despite existing studies suggesting correlations between metabolites RED, conclusive evidence remains scarce, primarily due observational nature these studies, which prone confounding factors.

Язык: Английский

Obesity and its impact on female reproductive health: unraveling the connections DOI Creative Commons
Lei Zheng,

Lixian Yang,

Ziru Guo

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Янв. 9, 2024

In the modern era, escalating global prevalence of obesity has profound implications on female reproductive health. Obesity, transcending mere lifestyle choices, evolved into a complex disorder affecting physiological and metabolic functions. Concurrently, infertility is rising as significant health issue. with its extensive systemic effects, pinpointed major disruptor. The convergence these challenges reveals multifaceted scenario: one hand, directly impacts health, particularly in context conditions like polycystic ovary syndrome (PCOS) menstrual disturbances; other, psychosocial consequences might intensify weight-gain patterns, forming challenging cycle. Additionally, economic treating obesity-related are considerable. This review delves myriad ways affects drawing insights from epidemiological, clinical, molecular studies. It explores epidemiological relationship between PCOS, influence disturbances, broader impact infertility. Weight loss, through pharmacological interventions, surgical methods, or adjustments, emerges promising strategy. Lastly, efficacy assisted technologies, such IVF, influenced by obesity, underscoring importance an optimal body mass index. also highlights mechanisms underlying including disruption hypothalamic-pituitary-ovary axis, altered adipokine secretion, role chronic inflammation oxidative stress.

Язык: Английский

Процитировано

40

Association between combined healthy lifestyles and infertility: a cross-sectional study in US reproductive-aged women DOI Creative Commons
Xiaofeng Ye, Song Xiao-xia, Sheng Zhou

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

2

The nonlinear association between body roundness index and infertility in married women DOI Creative Commons
Yong Fang, Dabin Ren,

Jin Pan

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 18, 2025

Infertility is increasingly linked to obesity, especially visceral fat accumulation. The Body Roundness Index (BRI) provides a precise quantification of body and but its implications for infertility risks diagnostic value are yet be fully determined. This study analyzed data from 1,305 married women aged 20-45 years, drawn the National Health Nutrition Examination Survey (NHANES). Logistic regression was utilized examine relationship between BRI infertility, incorporating univariate multivariate analyses, smooth curve fittings, subgroup analyses. Additionally, Receiver Operating Characteristic (ROC) analysis assessed predictive capability infertility. An increase in one unit correlated with 13% higher prevalence after adjusting covariates (OR = 1.13; 95% CI: 1.05, 1.21). Women exhibited greater odds compared reference group (OR: 2.20, 1.42, 3.42). Smooth fitting revealed positive, nonlinear relationship, an inflection point observed at 7.95. Subgroup analyses upheld robustness this association across varied demographic segments. ROC curves indicated significant potential younger women, whereas relevance diminished those over 35, akin other obesity markers. first rigorously affirm strong link increased among 20-45. To optimize fertility, maintaining healthy weight waist circumference recommended. integration into clinical practice could assist early intervention risk However, further research required identify effective markers 36-45.

Язык: Английский

Процитировано

1

Association between current relative fat mass and history of female infertility based on the NHANES survey DOI Creative Commons

Dong Liu,

Xiaoyan Luo,

Kunyan Zhou

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 21, 2025

Язык: Английский

Процитировано

0

Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study DOI Creative Commons

Huijing Shao,

Chang Xu, Haoran Wang

и другие.

Reproductive Biology and Endocrinology, Год журнала: 2025, Номер 23(1)

Опубликована: Май 14, 2025

Язык: Английский

Процитировано

0

HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy DOI Creative Commons
Tuo Zhang,

Yuntong Tong,

Rengguang Zhu

и другие.

Theranostics, Год журнала: 2024, Номер 14(6), С. 2345 - 2366

Опубликована: Янв. 1, 2024

Rationale: Primordial follicles are limited in number and cannot be regenerated, dormant primordial reversed once they enter a growth state.Therefore, the length of female reproductive lifespan depends on orderly progression selective activation follicles, mechanism which remains unclear.Methods: We used human ovarian cortical biopsy specimens, granulosa cells from diminished reserve (DOR) patients, Hdac6-overexpressing transgenic mouse model, RNA sequencing to analyze crucial roles histone deacetylase 6 (HDAC6) fertility preservation follicle activation.Results: In present study, we found that HDAC6 was highly expressed most follicles.The expression reduced accompanying senescence ovaries.Overexpression Hdac6 delayed rate activation, thereby prolonging lifespan.Short-term inhibition promoted follicular development humans mice.Mechanism studies revealed directly interacted with NGF, reducing acetylation modification NGF accelerating its ubiquitination degradation.Consequently, protein level maintained dormancy follicles. Conclusions:The physiological significance high is reduce prevent maintain fertility.Reduced increases activating their contributing reproduction.Our study provides clinical reference value for preservation.

Язык: Английский

Процитировано

3

Balancing nutrition for successful reproduction in ruminants DOI Creative Commons

Yitong Ding,

X Liu,

Yueming Guan

и другие.

Modern Agriculture, Год журнала: 2024, Номер 2(1)

Опубликована: Май 30, 2024

Abstract Proper nutrition is essential for sustaining optimal reproductive function in both humans and ruminants. Studies have shown that undernutrition overnutrition can negatively impact human processes. However, the Mediterranean diet, with its balanced nutrient‐rich composition, recognised positive effects on reproduction. In context of ruminants, a well‐balanced diet equally crucial achieving peak performance. Grazing, which allows ruminants to feed natural pasture open environments, contrasts indoor feeding, conducted more controlled settings. A dietary approach vital successful reproduction ruminant animals, combination grazing feeding has been identified as an effective strategy enhance their success. This review emphasises outcomes populations, advocating practices improve success across species. thorough understanding complex relationship between health offer valuable insights into enhancing fertility efficiency various contexts.

Язык: Английский

Процитировано

3

Association of body roundness index with female infertility: 2013–2018 NHANES DOI Creative Commons

Wenhui Wang,

Shibo Hou, Kun Wang

и другие.

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Окт. 30, 2024

This study aims to understand the association between body roundness index (BRI) and female infertility prevalence. Infertility is a public health concern with significant implications for individuals' well-being rights.

Язык: Английский

Процитировано

3

Association between relative fat mass and sterility in women of reproductive age in the United States: results from the 2013–2018 NHANES DOI Creative Commons
Mengmeng Sun, Yao Lu, Xi Yang

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Март 3, 2025

Background A major problem that affects women of reproductive age globally is sterility. new statistic called Relative Fat Mass (RFM) provides an accurate representation the percentage total body fat in people. This study aims to investigate relationship between RFM and sterility fertility-age American women. Methods employed a cross-sectional design using data collected from NHANES 2013 2018. The association was investigated logistic regression analysis, controlling for number variables. results were more resilient when transformed into four-category variable order further examine patterns different levels dose-response illustrated restricted cubic spline (RCS) analysis. Sensitivity subgroup analyses also conducted assess robustness consistency results. Results included 3,197 aged 18–45, consisting 2,854 non-sterile participants 343 sterile participants. First, fully adjusted model, prevalence had positive correlation (OR = 1.05, 95% CI 1.01–1.09). When converting continuous categorical variable, significantly greater highest quartile than lowest 2.59, 1.40–4.82). Furthermore, found be positively linearly correlated by RCS with rates sharply increasing as rose. frequency shown constant throughout various populations, according analysis across stratified parameters. Finally, sensitivity confirmed reliability study’s findings. Conclusion representative sample showed may help identify at risk sterility, waist circumference management could potentially lower

Язык: Английский

Процитировано

0

Effects of Obesity on Female Fertility: Mechanisms, Clinical Consequences and Management Strategies DOI

芙容 张

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(03), С. 1646 - 1653

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0