Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 31, 2024
Reproductive
endocrine
disorders
(RED),
including
polycystic
ovary
syndrome
(PCOS),
endometriosis
(EMs),
and
female
infertility
(FI),
significantly
affect
women's
health
globally,
with
varying
prevalence
across
different
regions.
These
conditions
can
be
addressed
through
medication,
surgical
interventions,
lifestyle
modifications.
However,
the
limited
understanding
of
RED's
etiology
substantial
economic
burden
its
treatment
highlight
importance
investigating
pathogenesis.
Metabolites
play
a
critical
role
in
metabolic
processes
are
potentially
linked
to
development
RED.
Despite
existing
studies
suggesting
correlations
between
metabolites
RED,
conclusive
evidence
remains
scarce,
primarily
due
observational
nature
these
studies,
which
prone
confounding
factors.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 9, 2024
In
the
modern
era,
escalating
global
prevalence
of
obesity
has
profound
implications
on
female
reproductive
health.
Obesity,
transcending
mere
lifestyle
choices,
evolved
into
a
complex
disorder
affecting
physiological
and
metabolic
functions.
Concurrently,
infertility
is
rising
as
significant
health
issue.
with
its
extensive
systemic
effects,
pinpointed
major
disruptor.
The
convergence
these
challenges
reveals
multifaceted
scenario:
one
hand,
directly
impacts
health,
particularly
in
context
conditions
like
polycystic
ovary
syndrome
(PCOS)
menstrual
disturbances;
other,
psychosocial
consequences
might
intensify
weight-gain
patterns,
forming
challenging
cycle.
Additionally,
economic
treating
obesity-related
are
considerable.
This
review
delves
myriad
ways
affects
drawing
insights
from
epidemiological,
clinical,
molecular
studies.
It
explores
epidemiological
relationship
between
PCOS,
influence
disturbances,
broader
impact
infertility.
Weight
loss,
through
pharmacological
interventions,
surgical
methods,
or
adjustments,
emerges
promising
strategy.
Lastly,
efficacy
assisted
technologies,
such
IVF,
influenced
by
obesity,
underscoring
importance
an
optimal
body
mass
index.
also
highlights
mechanisms
underlying
including
disruption
hypothalamic-pituitary-ovary
axis,
altered
adipokine
secretion,
role
chronic
inflammation
oxidative
stress.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 18, 2025
Infertility
is
increasingly
linked
to
obesity,
especially
visceral
fat
accumulation.
The
Body
Roundness
Index
(BRI)
provides
a
precise
quantification
of
body
and
but
its
implications
for
infertility
risks
diagnostic
value
are
yet
be
fully
determined.
This
study
analyzed
data
from
1,305
married
women
aged
20-45
years,
drawn
the
National
Health
Nutrition
Examination
Survey
(NHANES).
Logistic
regression
was
utilized
examine
relationship
between
BRI
infertility,
incorporating
univariate
multivariate
analyses,
smooth
curve
fittings,
subgroup
analyses.
Additionally,
Receiver
Operating
Characteristic
(ROC)
analysis
assessed
predictive
capability
infertility.
An
increase
in
one
unit
correlated
with
13%
higher
prevalence
after
adjusting
covariates
(OR
=
1.13;
95%
CI:
1.05,
1.21).
Women
exhibited
greater
odds
compared
reference
group
(OR:
2.20,
1.42,
3.42).
Smooth
fitting
revealed
positive,
nonlinear
relationship,
an
inflection
point
observed
at
7.95.
Subgroup
analyses
upheld
robustness
this
association
across
varied
demographic
segments.
ROC
curves
indicated
significant
potential
younger
women,
whereas
relevance
diminished
those
over
35,
akin
other
obesity
markers.
first
rigorously
affirm
strong
link
increased
among
20-45.
To
optimize
fertility,
maintaining
healthy
weight
waist
circumference
recommended.
integration
into
clinical
practice
could
assist
early
intervention
risk
However,
further
research
required
identify
effective
markers
36-45.
Theranostics,
Год журнала:
2024,
Номер
14(6), С. 2345 - 2366
Опубликована: Янв. 1, 2024
Rationale:
Primordial
follicles
are
limited
in
number
and
cannot
be
regenerated,
dormant
primordial
reversed
once
they
enter
a
growth
state.Therefore,
the
length
of
female
reproductive
lifespan
depends
on
orderly
progression
selective
activation
follicles,
mechanism
which
remains
unclear.Methods:
We
used
human
ovarian
cortical
biopsy
specimens,
granulosa
cells
from
diminished
reserve
(DOR)
patients,
Hdac6-overexpressing
transgenic
mouse
model,
RNA
sequencing
to
analyze
crucial
roles
histone
deacetylase
6
(HDAC6)
fertility
preservation
follicle
activation.Results:
In
present
study,
we
found
that
HDAC6
was
highly
expressed
most
follicles.The
expression
reduced
accompanying
senescence
ovaries.Overexpression
Hdac6
delayed
rate
activation,
thereby
prolonging
lifespan.Short-term
inhibition
promoted
follicular
development
humans
mice.Mechanism
studies
revealed
directly
interacted
with
NGF,
reducing
acetylation
modification
NGF
accelerating
its
ubiquitination
degradation.Consequently,
protein
level
maintained
dormancy
follicles.
Conclusions:The
physiological
significance
high
is
reduce
prevent
maintain
fertility.Reduced
increases
activating
their
contributing
reproduction.Our
study
provides
clinical
reference
value
for
preservation.
Abstract
Proper
nutrition
is
essential
for
sustaining
optimal
reproductive
function
in
both
humans
and
ruminants.
Studies
have
shown
that
undernutrition
overnutrition
can
negatively
impact
human
processes.
However,
the
Mediterranean
diet,
with
its
balanced
nutrient‐rich
composition,
recognised
positive
effects
on
reproduction.
In
context
of
ruminants,
a
well‐balanced
diet
equally
crucial
achieving
peak
performance.
Grazing,
which
allows
ruminants
to
feed
natural
pasture
open
environments,
contrasts
indoor
feeding,
conducted
more
controlled
settings.
A
dietary
approach
vital
successful
reproduction
ruminant
animals,
combination
grazing
feeding
has
been
identified
as
an
effective
strategy
enhance
their
success.
This
review
emphasises
outcomes
populations,
advocating
practices
improve
success
across
species.
thorough
understanding
complex
relationship
between
health
offer
valuable
insights
into
enhancing
fertility
efficiency
various
contexts.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 30, 2024
This
study
aims
to
understand
the
association
between
body
roundness
index
(BRI)
and
female
infertility
prevalence.
Infertility
is
a
public
health
concern
with
significant
implications
for
individuals'
well-being
rights.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Март 3, 2025
Background
A
major
problem
that
affects
women
of
reproductive
age
globally
is
sterility.
new
statistic
called
Relative
Fat
Mass
(RFM)
provides
an
accurate
representation
the
percentage
total
body
fat
in
people.
This
study
aims
to
investigate
relationship
between
RFM
and
sterility
fertility-age
American
women.
Methods
employed
a
cross-sectional
design
using
data
collected
from
NHANES
2013
2018.
The
association
was
investigated
logistic
regression
analysis,
controlling
for
number
variables.
results
were
more
resilient
when
transformed
into
four-category
variable
order
further
examine
patterns
different
levels
dose-response
illustrated
restricted
cubic
spline
(RCS)
analysis.
Sensitivity
subgroup
analyses
also
conducted
assess
robustness
consistency
results.
Results
included
3,197
aged
18–45,
consisting
2,854
non-sterile
participants
343
sterile
participants.
First,
fully
adjusted
model,
prevalence
had
positive
correlation
(OR
=
1.05,
95%
CI
1.01–1.09).
When
converting
continuous
categorical
variable,
significantly
greater
highest
quartile
than
lowest
2.59,
1.40–4.82).
Furthermore,
found
be
positively
linearly
correlated
by
RCS
with
rates
sharply
increasing
as
rose.
frequency
shown
constant
throughout
various
populations,
according
analysis
across
stratified
parameters.
Finally,
sensitivity
confirmed
reliability
study’s
findings.
Conclusion
representative
sample
showed
may
help
identify
at
risk
sterility,
waist
circumference
management
could
potentially
lower
