Obesity and its impact on female reproductive health: unraveling the connections

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Янв. 9, 2024

In the modern era, escalating global prevalence of obesity has profound implications on female reproductive health. Obesity, transcending mere lifestyle choices, evolved into a complex disorder affecting physiological and metabolic functions. Concurrently, infertility is rising as significant health issue. with its extensive systemic effects, pinpointed major disruptor. The convergence these challenges reveals multifaceted scenario: one hand, directly impacts health, particularly in context conditions like polycystic ovary syndrome (PCOS) menstrual disturbances; other, psychosocial consequences might intensify weight-gain patterns, forming challenging cycle. Additionally, economic treating obesity-related are considerable. This review delves myriad ways affects drawing insights from epidemiological, clinical, molecular studies. It explores epidemiological relationship between PCOS, influence disturbances, broader impact infertility. Weight loss, through pharmacological interventions, surgical methods, or adjustments, emerges promising strategy. Lastly, efficacy assisted technologies, such IVF, influenced by obesity, underscoring importance an optimal body mass index. also highlights mechanisms underlying including disruption hypothalamic-pituitary-ovary axis, altered adipokine secretion, role chronic inflammation oxidative stress.

Язык: Английский

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Association between combined healthy lifestyles and infertility: a cross-sectional study in US reproductive-aged women

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 14, 2025

Язык: Английский

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The nonlinear association between body roundness index and infertility in married women

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 18, 2025

Infertility is increasingly linked to obesity, especially visceral fat accumulation. The Body Roundness Index (BRI) provides a precise quantification of body and but its implications for infertility risks diagnostic value are yet be fully determined. This study analyzed data from 1,305 married women aged 20-45 years, drawn the National Health Nutrition Examination Survey (NHANES). Logistic regression was utilized examine relationship between BRI infertility, incorporating univariate multivariate analyses, smooth curve fittings, subgroup analyses. Additionally, Receiver Operating Characteristic (ROC) analysis assessed predictive capability infertility. An increase in one unit correlated with 13% higher prevalence after adjusting covariates (OR = 1.13; 95% CI: 1.05, 1.21). Women exhibited greater odds compared reference group (OR: 2.20, 1.42, 3.42). Smooth fitting revealed positive, nonlinear relationship, an inflection point observed at 7.95. Subgroup analyses upheld robustness this association across varied demographic segments. ROC curves indicated significant potential younger women, whereas relevance diminished those over 35, akin other obesity markers. first rigorously affirm strong link increased among 20-45. To optimize fertility, maintaining healthy weight waist circumference recommended. integration into clinical practice could assist early intervention risk However, further research required identify effective markers 36-45.

Язык: Английский

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HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy

Theranostics, Год журнала: 2024, Номер 14(6), С. 2345 - 2366

Опубликована: Янв. 1, 2024

Rationale: Primordial follicles are limited in number and cannot be regenerated, dormant primordial reversed once they enter a growth state.Therefore, the length of female reproductive lifespan depends on orderly progression selective activation follicles, mechanism which remains unclear.Methods: We used human ovarian cortical biopsy specimens, granulosa cells from diminished reserve (DOR) patients, Hdac6-overexpressing transgenic mouse model, RNA sequencing to analyze crucial roles histone deacetylase 6 (HDAC6) fertility preservation follicle activation.Results: In present study, we found that HDAC6 was highly expressed most follicles.The expression reduced accompanying senescence ovaries.Overexpression Hdac6 delayed rate activation, thereby prolonging lifespan.Short-term inhibition promoted follicular development humans mice.Mechanism studies revealed directly interacted with NGF, reducing acetylation modification NGF accelerating its ubiquitination degradation.Consequently, protein level maintained dormancy follicles. Conclusions:The physiological significance high is reduce prevent maintain fertility.Reduced increases activating their contributing reproduction.Our study provides clinical reference value for preservation.

Язык: Английский

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Association between current relative fat mass and history of female infertility based on the NHANES survey

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 21, 2025

Язык: Английский

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Association between relative fat mass and sterility in women of reproductive age in the United States: results from the 2013–2018 NHANES

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Март 3, 2025

Background A major problem that affects women of reproductive age globally is sterility. new statistic called Relative Fat Mass (RFM) provides an accurate representation the percentage total body fat in people. This study aims to investigate relationship between RFM and sterility fertility-age American women. Methods employed a cross-sectional design using data collected from NHANES 2013 2018. The association was investigated logistic regression analysis, controlling for number variables. results were more resilient when transformed into four-category variable order further examine patterns different levels dose-response illustrated restricted cubic spline (RCS) analysis. Sensitivity subgroup analyses also conducted assess robustness consistency results. Results included 3,197 aged 18–45, consisting 2,854 non-sterile participants 343 sterile participants. First, fully adjusted model, prevalence had positive correlation (OR = 1.05, 95% CI 1.01–1.09). When converting continuous categorical variable, significantly greater highest quartile than lowest 2.59, 1.40–4.82). Furthermore, found be positively linearly correlated by RCS with rates sharply increasing as rose. frequency shown constant throughout various populations, according analysis across stratified parameters. Finally, sensitivity confirmed reliability study’s findings. Conclusion representative sample showed may help identify at risk sterility, waist circumference management could potentially lower

Язык: Английский

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Effects of Obesity on Female Fertility: Mechanisms, Clinical Consequences and Management Strategies

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(03), С. 1646 - 1653

Опубликована: Янв. 1, 2025

Язык: Английский

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Association between pelvic inflammatory disease and infertility in American women : Results from the National Health and Nutrition Survey 2013 to 2018

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Introduction Recently, the incidence of pelvic inflammatory disease (PID)-associated infertility has gradually increased. Understanding relationship between PID and is crucial in fields healthcare public health. This study aimed to clarify association describe implications this association. Methods retrospective cross-sectional included 2,819 female participants aged 20–44 years from United States, using data National Health Nutrition Examination Survey (NHANES). NHANES employs a complex multi-stage probabilistic design, were collected through questionnaires, physical examinations, laboratory tests. We used multivariate logistic regression models evaluate (PID) infertility. Additionally, we applied propensity score matching (PSM) method match group with comparable baseline cohort general population, allowing for more robust analysis correlation Furthermore, performed stratification interaction analyses assess consistency across different subgroups. Results Among eligible women, 315 had A multivariable revealed that women who received treatment positively correlated (odds ratio: 2.20; 95% confidence interval: 1.42–3.41; P = 0.001) after controlling all other factors. Subgroup showed consistent pattern, no significant difference test. The positive PSM 2.01; 1.38–2.95; P<0.001). Moreover, additional sensitivity confirmed robustness main findings. Conclusions Our suggests potential infertility, emphasizing importance considering managing clinical practice.

Язык: Английский

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Transcriptome analysis of early embryonic development in a mouse model of polycystic ovary syndrome

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Май 2, 2025

Polycystic ovary syndrome (PCOS) is a complex disorder that originates during fetal development and significantly impairs female fertility the reproductive years. Although it hypothesized prenatal exposure to elevated androgen levels plays crucial role in pathogenesis of PCOS, precise effects such on offspring individuals with PCOS remain unclear. In this study, we established mouse model by administering dihydrotestosterone (DHT) prenatally. We subsequently evaluated phenotype PCOS-like mice, focusing ovarian function embryo developmental potential. Smart-seqII RNA sequencing was performed blastocysts obtain expression profile preimplantation embryos from mice. These findings indicate mice exhibit hyperandrogenic symptoms, reduced ovulation rates, impaired oocytes compared controls. Furthermore, 918 differentially expressed genes were identified blastocyst samples, significant enrichment pathways related intracellular energy metabolism, tissue development, glycolipid hormone synthesis, inflammation. This research presents direct evidence hyperandrogenism negatively influences early embryonic later manifestation polycystic adulthood. contribute valuable insights for prevention PCOS.

Язык: Английский

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Association between cardiometabolic index and infertility risk: a cross-sectional analysis of NHANES data (2013–2018)

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Май 2, 2025

The cardiometabolic index (CMI), a novel measure of obesity that integrates lipid profiles and indicators abdominal adiposity, has emerged as promising marker metabolic health. However, its relationship with infertility remains largely unexplored. Using data from the National Health Nutrition Examination Survey (NHANES) conducted between 2013 2018, this study investigated potential association CMI risk. We utilized weighted multivariate logistic regression to examine employed restricted cubic spline model explore non-linear relationships. Interaction tests subgroups analyses were assess heterogeneity across different subgroups. analysis included nationally representative cohort 1,142 women. After controlling for confounders, positive was identified risk (OR: 1.47; 95% CI: 1.05-2.06; p = 0.028). revealed (p 0.0109), an inflection point at value 0.341. Our findings provides evidence among U.S. adults. These results suggest could serve simple effective surrogate assessment, offering valuable insights reproductive health management.

Язык: Английский

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