Abstract
Due
to
excellent
biocompatibility,
sufficient
raw
material,
robust
mechanical
properties
and
easy
cross‐linking,
Silk
Fibroin
(SF)
is
a
promising
protein
for
3D
printing
inks
an
ideal
candidate
scaffolds
in
fields
like
regenerative
medicine,
bioelectronics
bio‐optics.
In
order
meet
the
requirements
of
print
accuracy,
form
retention
capabilities,
first
step
prepare
SF
using
physical,
chemical
or
other
strategies
cross‐linking.
The
basic
groups
physical
structure
determines
its
ability
networks
under
different
conditions
various
cross‐linking
strategies.
preparation
SF‐based
inks,
improve
qualities
printing,
but
each
strategy
has
advantages
disadvantages.
This
paper
discusses
crosslinking
support
development
exciting
potential
more
needs
future.
Advanced Engineering Materials,
Год журнала:
2023,
Номер
25(21)
Опубликована: Авг. 29, 2023
Stimuli‐responsive
polymers
(SRPs)
are
special
types
of
soft
materials,
which
have
been
extensively
used
for
developing
flexible
actuators,
robots,
wearable
devices,
sensors,
self‐expanding
structures,
and
biomedical
thanks
to
their
ability
change
shapes
functional
properties
in
response
external
stimuli
including
light,
humidity,
heat,
pH,
electric
field,
solvent,
magnetic
field
or
combinations
two
more
these
stimuli.
In
recent
years,
additive
manufacturing
(AM)
aka
3D
printing
technology
SRPs,
also
known
as
4D
printing,
has
gained
phenomenal
attention
different
engineering
fields,
its
unique
develop
complex,
personalized,
innovative
undergo
twisting,
elongating,
swelling,
rolling,
shrinking,
bending,
spiraling,
other
complex
morphological
transformations.
Herein,
an
effort
made
provide
insightful
information
about
the
AM
techniques,
type
applications
including,
but
not
limited
tissue
engineering,
bionics,
construction,
smart
textiles.
This
article
incorporates
current
challenges
prospects,
hoping
basis
utilization
this
fields.
It
is
expected
that
amalgamation
with
SRPs
would
unparalleled
advantages
arenas.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(7)
Опубликована: Окт. 10, 2023
Abstract
Congenital
and
acquired
valvular
heart
diseases
(VHDs)
are
significant
causes
of
mortality
worldwide.
With
valve
replacement
being
the
primary
solution
for
VHD,
current
options
display
shortcomings,
including
calcification,
thrombogenicity,
hemodynamic
alteration,
leading
to
repetitive
surgeries.
Tissue
engineering,
however,
has
shown
great
potential
fabricating
valves
(HVs)
with
fewer
complications.
Here,
a
series
inks
developed,
combining
poly(vinyl
alcohol),
gelatin,
carrageenan
3D
printing
tissue‐engineered
(TEHVs).
The
inks/hydrogels
investigated
characterize
their
physico‐chemical,
morphological,
mechanical,
rheological
characteristics.
In
vitro
in
vivo
biocompatibility,
immune
response,
hemolysis,
thrombogenicity
also
evaluated.
Moreover,
hydrodynamics
TEHVs
under
physiological
conditions
reported.
Inks
demonstrate
mechanical
characteristics
comparable
native
leaflets.
Subcutaneous
implantation
reveals
that
hydrogels
do
not
induce
chronic
inflammation
can
undergo
remodeling.
hemocompatibility
assessments
show
minimal
hemolysis
low
thrombogenicity.
Different
sizes
types
HVs
successfully
printed
high
fidelity
air.
hydrodynamic
assessment
confirms
withstand
aortic
conditions.
Altogether,
3D‐printed
be
promising
alternative
solve
problems
associated
options.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 10, 2024
Traditional
tissue
engineering
methods
face
challenges,
such
as
fabrication,
implantation
of
irregularly
shaped
scaffolds,
and
limited
accessibility
for
immediate
healthcare
providers.
In
situ
bioprinting,
an
alternate
strategy,
involves
direct
deposition
biomaterials,
cells,
bioactive
factors
at
the
site,
facilitating
on-site
fabrication
intricate
tissue,
which
can
offer
a
patient-specific
personalized
approach
align
with
principles
precision
medicine.
It
be
applied
using
handled
device
robotic
arms
to
various
tissues,
including
skin,
bone,
cartilage,
muscle,
composite
tissues.
Bioinks,
critical
components
bioprinting
that
support
cell
viability
development,
play
crucial
role
in
success
bioprinting.
This
review
discusses
techniques,
materials
used
bioinks,
their
properties
successful
applications.
Finally,
we
discuss
challenges
future
trends
accelerating
printing
translate
this
technology
clinical
settings
regenerative
iScience,
Год журнала:
2025,
Номер
28(3), С. 111882 - 111882
Опубликована: Янв. 23, 2025
Cardiac
tissue
lacks
regenerative
capacity,
making
heart
transplantation
the
primary
treatment
for
end-stage
failure.
Engineered
cardiac
tissues
developed
through
three-dimensional
bioprinting
(3DBP)
offer
a
promising
alternative.
However,
reproducing
native
structure,
cellular
diversity,
and
functionality
of
requires
advanced
bioinks.
Major
obstacles
in
CTE
(cardiac
engineering)
include
accurately
characterizing
bioink
properties,
replicating
microenvironment,
achieving
precise
spatial
organization.
Optimizing
properties
to
closely
mimic
extracellular
matrix
(ECM)
is
essential,
as
deviations
may
result
pathological
effects.
This
review
encompasses
rheological
electromechanical
bioinks
function
microenvironment
design
functional
constructs.
Furthermore,
it
focuses
on
improving
characteristics,
printability,
bioinks,
offering
valuable
perspectives
developing
new
especially
designed
CTE.
Abstract
Engineered
three-dimensional
(3D)
tissue
constructs
have
emerged
as
a
promising
solution
for
regenerating
damaged
muscle
resulting
from
traumatic
or
surgical
events.
3D
architecture
and
function
of
the
can
be
customized
by
selecting
types
biomaterials
cells
that
engineered
with
desired
shapes
sizes
through
various
nano-
micro-fabrication
techniques.
Despite
significant
progress
in
this
field,
further
research
is
needed
to
improve,
terms
properties
fabrication
techniques,
resemblance
complex
native
tissues,
potentially
enhancing
regeneration
restoring
function.
In
review,
we
discuss
latest
trends
using
nano-biomaterials
advanced
nano-/micro-fabrication
techniques
creating
their
ability.
Current
challenges
potential
solutions
are
highlighted,
implications
opportunities
future
perspective
including
possibility
personalized
biomanufacturable
platforms.
