Cross‐Linking Strategies for Silk‐Protein‐Based Inks for 3D Printing DOI

Xiaoyuan Dong,

Fengqiang Liu, Liming Wang

et al.

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(41)

Published: Nov. 2, 2023

Abstract Due to excellent biocompatibility, sufficient raw material, robust mechanical properties and easy cross‐linking, Silk Fibroin (SF) is a promising protein for 3D printing inks an ideal candidate scaffolds in fields like regenerative medicine, bioelectronics bio‐optics. In order meet the requirements of print accuracy, form retention capabilities, first step prepare SF using physical, chemical or other strategies cross‐linking. The basic groups physical structure determines its ability networks under different conditions various cross‐linking strategies. preparation SF‐based inks, improve qualities printing, but each strategy has advantages disadvantages. This paper discusses crosslinking support development exciting potential more needs future.

Language: Английский

Revolutionizing manufacturing: A comprehensive overview of additive manufacturing processes, materials, developments, and challenges DOI
Kumar Kanishka, Bappa Acherjee

Journal of Manufacturing Processes, Journal Year: 2023, Volume and Issue: 107, P. 574 - 619

Published: Nov. 8, 2023

Language: Английский

Citations

116
Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers DOI Creative Commons
Ali Tariq, Zia Ullah Arif, Muhammad Yasir Khalid

et al.

Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 25(21)

Published: Aug. 29, 2023

Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.

Language: Английский

Citations

86
Formulation and Evaluation of PVA/Gelatin/Carrageenan Inks for 3D Printing and Development of Tissue‐Engineered Heart Valves DOI Creative Commons
Arman Jafari, Seyyed Vahid Niknezhad, Maryam Kaviani

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)

Published: Oct. 10, 2023

Abstract Congenital and acquired valvular heart diseases (VHDs) are significant causes of mortality worldwide. With valve replacement being the primary solution for VHD, current options display shortcomings, including calcification, thrombogenicity, hemodynamic alteration, leading to repetitive surgeries. Tissue engineering, however, has shown great potential fabricating valves (HVs) with fewer complications. Here, a series inks developed, combining poly(vinyl alcohol), gelatin, carrageenan 3D printing tissue‐engineered (TEHVs). The inks/hydrogels investigated characterize their physico‐chemical, morphological, mechanical, rheological characteristics. In vitro in vivo biocompatibility, immune response, hemolysis, thrombogenicity also evaluated. Moreover, hydrodynamics TEHVs under physiological conditions reported. Inks demonstrate mechanical characteristics comparable native leaflets. Subcutaneous implantation reveals that hydrogels do not induce chronic inflammation can undergo remodeling. hemocompatibility assessments show minimal hemolysis low thrombogenicity. Different sizes types HVs successfully printed high fidelity air. hydrodynamic assessment confirms withstand aortic conditions. Altogether, 3D‐printed be promising alternative solve problems associated options.

Language: Английский

Citations

35
In Situ Bioprinting: Process, Bioinks, and Applications DOI
Pooja Jain, Himanshu Kathuria, Seeram Ramakrishna

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: April 10, 2024

Traditional tissue engineering methods face challenges, such as fabrication, implantation of irregularly shaped scaffolds, and limited accessibility for immediate healthcare providers. In situ bioprinting, an alternate strategy, involves direct deposition biomaterials, cells, bioactive factors at the site, facilitating on-site fabrication intricate tissue, which can offer a patient-specific personalized approach align with principles precision medicine. It be applied using handled device robotic arms to various tissues, including skin, bone, cartilage, muscle, composite tissues. Bioinks, critical components bioprinting that support cell viability development, play crucial role in success bioprinting. This review discusses techniques, materials used bioinks, their properties successful applications. Finally, we discuss challenges future trends accelerating printing translate this technology clinical settings regenerative

Language: Английский

Citations

9
Harnessing Native Blueprints for Designing Bioinks to Bioprint Functional Cardiac Tissue DOI Creative Commons

Mst Zobaida Akter,

Fatima Tufail, Ashfaq Ahmad

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(3), P. 111882 - 111882

Published: Jan. 23, 2025

Cardiac tissue lacks regenerative capacity, making heart transplantation the primary treatment for end-stage failure. Engineered cardiac tissues developed through three-dimensional bioprinting (3DBP) offer a promising alternative. However, reproducing native structure, cellular diversity, and functionality of requires advanced bioinks. Major obstacles in CTE (cardiac engineering) include accurately characterizing bioink properties, replicating microenvironment, achieving precise spatial organization. Optimizing properties to closely mimic extracellular matrix (ECM) is essential, as deviations may result pathological effects. This review encompasses rheological electromechanical bioinks function microenvironment design functional constructs. Furthermore, it focuses on improving characteristics, printability, bioinks, offering valuable perspectives developing new especially designed CTE.

Language: Английский

Citations

1
Development of silk microfiber-reinforced bioink for muscle tissue engineering and in situ printing by a handheld 3D printer DOI
Meenakshi Kamaraj, Omid Rezayof,

A. S. Barer

et al.

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 166, P. 214057 - 214057

Published: Sept. 30, 2024

Language: Английский

Citations

5
Nano-biomaterials and advanced fabrication techniques for engineering skeletal muscle tissue constructs in regenerative medicine DOI Creative Commons

Seokgyu Han,

Sebastián Herrera Cruz,

Sungsu Park

et al.

Nano Convergence, Journal Year: 2023, Volume and Issue: 10(1)

Published: Oct. 21, 2023

Abstract Engineered three-dimensional (3D) tissue constructs have emerged as a promising solution for regenerating damaged muscle resulting from traumatic or surgical events. 3D architecture and function of the can be customized by selecting types biomaterials cells that engineered with desired shapes sizes through various nano- micro-fabrication techniques. Despite significant progress in this field, further research is needed to improve, terms properties fabrication techniques, resemblance complex native tissues, potentially enhancing regeneration restoring function. In review, we discuss latest trends using nano-biomaterials advanced nano-/micro-fabrication techniques creating their ability. Current challenges potential solutions are highlighted, implications opportunities future perspective including possibility personalized biomanufacturable platforms.

Language: Английский

Citations

13
Multi-material and multi-scale platform for robotic based in situ bioprinting DOI Creative Commons
Andrea Guerra, Gabriele Maria Fortunato, Elisa Batoni

et al.

Results in Engineering, Journal Year: 2025, Volume and Issue: 25, P. 104219 - 104219

Published: Jan. 31, 2025

Citations

0
Reinforcement of injectable hydrogels through melt electro-written structures: influence of shape and pore size on the injection force DOI Creative Commons
Diego Trucco, Rory Gibney, Lorenzo Vannozzi

et al.

Journal of Materials Research and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Recent Advances in Handheld and Robotic Bioprinting Approach for Tissue Engineering DOI
Meenakshi Kamaraj, Nafiseh Moghimi, Akshat Joshi

et al.

Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract 3D bioprinting has emerged as a transformative technology in tissue engineering, significantly impacting the creation of patient‐specific tissues to enhance clinical outcomes. Despite its rapid advancement, translating this from bench bedside remains critical need. New approaches, such handheld printers or robotic arm‐driven situ biofabrication techniques, have promising alternatives. These advancements enable reconstruction damaged directly on living anatomical structures, offering adaptability and precise matching affected area. The integration biomaterials, engineering principles, digital technologies, particularly robotics, garnered substantial interest both academic industrial sectors, highlighting potential for applications. However, challenges persist, including refining bioink formulations, adjusting mechanical properties, facilitating crosslinking, accurately mimicking extracellular matrix. This review explores cutting‐edge frontier regeneration, utilizing arm‐assisted printers. It systematically examines relative advantages, disadvantages, challenges, prospects it transitions side bed side.

Language: Английский

Citations

0