Materials Today Communications, Год журнала: 2025, Номер unknown, С. 112094 - 112094
Опубликована: Март 1, 2025
Язык: Английский
Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(9), С. 455 - 455
Опубликована: Сен. 3, 2023
Biomaterials are at the forefront of future, finding a variety applications in biomedical field, especially wound healing, thanks to their biocompatible and biodegradable properties. Wounds spontaneously try heal through series interconnected processes involving several initiators mediators such as cytokines, macrophages, fibroblasts. The combination biopolymers with healing properties may provide opportunities synthesize matrices that stimulate trigger target cell responses crucial process. This review outlines optimal management care required for treatment special focus on biopolymers, drug-delivery systems, nanotechnologies used enhanced applications. Researchers have utilized range techniques produce dressings, leading products different characteristics. Each method comes its unique strengths limitations, which important consider. future trajectory dressing advancement should prioritize economical eco-friendly methodologies, along improving efficacy constituent materials. aim this work is give researchers possibility evaluate proper materials preparation better understand synthesis conditions well most effective bioactive molecules load.
Язык: Английский
Процитировано
67
E3S Web of Conferences, Год журнала: 2023, Номер 430, С. 01198 - 01198
Опубликована: Янв. 1, 2023
The research investigates Functionally Graded Materials (FGMs) and their transformational potential in modern engineering. FGMs, which exhibit progressive property fluctuations, call into question traditional material consistency. This study analyses the growth of FGMs importance solving complex engineering difficulties through historical analysis real-world case studies. dives design concepts, selection, manufacturing procedures, sophisticated characterisation methodologies that underpin FGM development from a methodological standpoint. Mechanical, thermal, electrical characteristics, combination with microstructural progression, offer thorough knowledge behaviour. implications for future advances are highlighted, focus on ability to rethink multifunctional performance. Among many attractive possibilities, issues scalability, characterisation, multidisciplinary cooperation need additional investigation. represent paradigm shift homogeneity targeted heterogeneity, echoing wider shifts philosophy influencing technological development.
Язык: Английский
Процитировано
63
Advances in Colloid and Interface Science, Год журнала: 2024, Номер 324, С. 103095 - 103095
Опубликована: Янв. 28, 2024
Direct ink writing (DIW) stands as a pioneering additive manufacturing technique that holds transformative potential in the field of hydrogel fabrication. This innovative approach allows for precise deposition inks layer by layer, creating complex three-dimensional structures with tailored shapes, sizes, and functionalities. By harnessing versatility hydrogels, DIW opens up possibilities applications spanning from tissue engineering to soft robotics wearable devices. comprehensive review investigates applied hydrogels its multifaceted applications. The paper introduces diverse range printing techniques while providing thorough exploration hydrogel-based printing. investigation aims explain progress made, challenges faced, trajectories lie ahead manufacturing. fundamental principles underlying are carefully examined, specifically focusing on rheological attributes parameters, prompting survey wide variety materials. These encompass both natural synthetic variations, all which can be effectively harnessed this purpose. Furthermore, explores latest biomedical areas, primary focus engineering, wound dressing, drug delivery systems. document not only consolidates existing state within context but also charts avenues further research breakthroughs.
Язык: Английский
Процитировано
54
Materials & Design, Год журнала: 2024, Номер 240, С. 112853 - 112853
Опубликована: Март 19, 2024
3D bioprinting techniques have emerged as a flexible tool in tissue engineering and regenerative medicine to fabricate or pattern functional bio-structures with precise geometric designs, bridging the divergence between engineered natural constructs. A significantly increasing development has been achieved understanding relationship 3D-printing process structures, properties, applications of objects created. The ongoing advancement novel biomaterial inks enabled manufacturing models vitro implants capable achieving some level success preclinical trials. Remarkable progress cell biology biology-inspired computational design assisted latest milestone planned tissue- organ-like constructs having specific levels functionality. However, biofabricated still long way go before reaching clinics. This review presents picture context medicine, focus on biomaterials-related design-centred aspects. Biomedical are described detail relation major tissues organs considered human body. Current technical limitations, challenges, future prospects improvements critically outlined discussed.
Язык: Английский
Процитировано
45
Bioactive Materials, Год журнала: 2025, Номер 48, С. 273 - 293
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
3
European Polymer Journal, Год журнала: 2024, Номер 209, С. 112864 - 112864
Опубликована: Фев. 23, 2024
Self-healing hydrogels are the most promising hydrogel-ink materials, especially for extrusion-based 3D-bioprinting, because, unlike traditional hydrogels, bonds as well their initial structure, properties and functionality can be recovered after extrusion, which together with shear-thinning property enables safe printing cells, but also shape stability of construct printing. In addition to tunable viscoelastic given by these inks, they respond cell forces rearranging network, while maintaining bulk physiological properties. Currently, mainly bioprinting has been used types dynamic inks. Some basic 3D structures, such letters, grids patterns, have printed high fidelity viability using 3D-bioprinting. More complex spiral, pyramidal, or vascular tree structures so-called gel-in-gel technique, even some overhang geometries without need additional support bath. The current limitation self-healing hydrogel inks poor mechanical stability, improved, example, crosslinking. However, opposing characteristics like toughness fast self-healability, remain a challenge. Therefore, more studies needed in future improve This review collects relevant related 3D-bioprintable hydrogels. It discusses importance bioinks bioprinted constructs, effects on cells (and vice versa), status prospects bioinks.
Язык: Английский
Процитировано
13
Polymer Bulletin, Год журнала: 2024, Номер unknown
Опубликована: Сен. 30, 2024
Язык: Английский
Процитировано
12
Acta Biomaterialia, Год журнала: 2024, Номер 181, С. 46 - 66
Опубликована: Апрель 30, 2024
Skeletal muscle is a pro-regenerative tissue, that utilizes tissue-resident stem cell system to effect repair upon injury. Despite the demonstrated efficiency of this in restoring mass after many acute injuries, conditions severe trauma such as those evident volumetric loss (VML) (>20% by mass), self-repair capability unable restore tissue architecture, requiring interventions which currently are largely surgical. As possible alternative, generation artificial using engineering approaches may also be importance treatment VML and diseases dystrophies. Three-dimensional (3D) bioprinting has been identified promising technique for regeneration complex architecture skeletal muscle. This review discusses existing strategies following damage, recent progress techniques, bioinks used regeneration, immunogenicity scaffold materials, vitro vivo maturation techniques 3D bio-printed constructs. The pros cons these bioink formulations highlighted. Finally, we present current limitations challenges field critical factors consider become more translational produce clinically relevant engineered physiopathology injuries clinical types have applied muscle, commonly regeneration. We discussion gaps literature translation provide insights into what believe will next steps required before realization application tissue-engineered humans. manuscript an insightful, timely, instructive guide future research from fundamental construct creation approach, down pathway achieve desired impact clinic.
Язык: Английский
Процитировано
10
Bioactive Materials, Год журнала: 2024, Номер 43, С. 195 - 224
Опубликована: Сен. 24, 2024
Язык: Английский
Процитировано
10
Current Opinion in Colloid & Interface Science, Год журнала: 2025, Номер unknown, С. 101918 - 101918
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
2