Beyond hype: unveiling the Real challenges in clinical translation of 3D printed bone scaffolds and the fresh prospects of bioprinted organoids
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 21, 2024
Bone
defects
pose
significant
challenges
in
healthcare,
with
over
2
million
bone
repair
surgeries
performed
globally
each
year.
As
a
burgeoning
force
the
field
of
tissue
engineering,
3D
printing
offers
novel
solutions
to
traditional
transplantation
procedures.
However,
current
3D-printed
scaffolds
still
face
three
critical
material
selection,
methods,
cellular
self-organization
and
co-culture,
significantly
impeding
their
clinical
application.
In
this
comprehensive
review,
we
delve
into
performance
criteria
that
ideal
should
possess,
particular
focus
on
core
faced
by
technology
during
translation.
We
summarize
latest
advancements
non-traditional
materials
advanced
techniques,
emphasizing
importance
integrating
organ-like
technologies
bioprinting.
This
combined
approach
enables
more
precise
simulation
natural
structure
function.
Our
aim
writing
review
is
propose
effective
strategies
address
these
promote
translation
for
defect
treatment.
Язык: Английский
Developing functional hydrogels for treatment of oral diseases
Smart Medicine,
Год журнала:
2024,
Номер
3(3)
Опубликована: Июль 25, 2024
Oral
disease
is
a
severe
healthcare
challenge
that
diminishes
people's
quality
of
life.
Functional
hydrogels
with
suitable
biodegradability,
biocompatibility,
and
tunable
mechanical
properties
have
attracted
remarkable
interest
been
developed
for
treating
oral
diseases.
In
this
review,
we
present
up-to-date
research
on
the
management
dental
caries,
endodontics,
periapical
periodontitis,
depending
progression
The
strategies
mucosal
diseases
salivary
gland
are
then
classified.
After
that,
focus
application
related
to
tumor
therapy
tissue
defects.
Finally,
review
prospects
restrictions
perspectives
utilization
in
treatment.
We
believe
will
promote
advancement
more
amicable,
functional
personalized
approaches
Язык: Английский
Effects of Chrono-Exercise and Chrono-Nutrition on Muscle Health: Understanding the Molecular Mechanisms Activated by Timed Exercise and Consumption of Proteins and Carbohydrates
Nutrition Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
The
circadian
clock
is
an
endogenous
timekeeping
system
that
regulates
various
physiological
and
behavioral
processes.
Recently,
it
has
been
shown
the
timing
of
physical
activity
food
intake
can
significantly
influence
metabolic
muscle
health.
Some
recent
clinical
evidence
practiced
in
late
afternoon
be
more
effective
terms
performance
strength.
Preclinical
studies
have
highlighted
explanation
for
this
effect
lies
different
daily
expression
genes
clock-controlled
involved
development
hypertrophy.
In
conjunction
with
scientific
advances
understanding
molecular
mechanisms
regulate
rhythms
trophy,
chrono-nutrition
gained
resonance
become
a
promising
field,
aimed
at
regulation
body
metabolism.
Clinical
preclinical
protein
consumption
specific
time
points
during
day,
or
precisely
after
exercise,
activate
signaling
pathways
synthesis
and,
thus,
favor
skeletal
mass
as
well
mitochondrial
biogenesis,
thereby
improving
cell
energy
production
function.
On
other
hand,
some
carbohydrates
immediately
exercise
increases
insulin
secretion,
which
facilitates
glucose
uptake
by
cells
to
replenish
glycogen.
This
review
summarizes
current
literature
concerning
chrono-exercise
health,
focusing
on
involving
mass,
strength,
Understanding
intricate
relationship
between
rhythms,
nutrition,
metabolism
essential
optimizing
nutritional
strategies
prevent
treat
wasting.
addition,
tailoring
carbohydrate
individual
needs
improve
maintenance,
growth,
performance.
Язык: Английский
Leveraging Large Language Models for Accelerated Learning and Innovation in Biogenic Tissue-Engineered Vascular Grafts
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106935 - 106935
Опубликована: Апрель 1, 2025
Язык: Английский
Tissue Engineering and Regenerative Medicine: Perspectives and Challenges
MedComm,
Год журнала:
2025,
Номер
6(5)
Опубликована: Апрель 24, 2025
ABSTRACT
From
the
pioneering
days
of
cell
therapy
to
achievement
bioprinting
organs,
tissue
engineering,
and
regenerative
medicine
have
seen
tremendous
technological
advancements,
offering
solutions
for
restoring
damaged
tissues
organs.
However,
only
a
few
products
technologies
received
United
States
Food
Drug
Administration
approval.
This
review
highlights
significant
progress
in
therapy,
extracellular
vesicle‐based
engineering.
Hematopoietic
stem
transplantation
is
powerful
tool
treating
many
diseases,
especially
hematological
malignancies.
Mesenchymal
cells
been
extensively
studied.
The
discovery
induced
pluripotent
has
revolutionized
disease
modeling
applications,
paving
way
personalized
medicine.
Gene
represents
an
innovative
approach
treatment
genetic
disorders.
Additionally,
therapies
emerged
as
rising
stars,
promising
diagnostics,
cell‐free
therapeutics,
drug
delivery,
targeted
therapy.
Advances
engineering
enable
complex
constructs,
further
transforming
field.
Despite
these
technical,
ethical,
regulatory
challenges
remain.
addresses
current
bottlenecks,
emphasizing
novel
interdisciplinary
research
overcome
hurdles.
Standardizing
practices
conducting
clinical
trials
will
balance
innovation
regulation,
improving
patient
outcomes
quality
life.
Язык: Английский
Bioprinting Taurine-Incorporated Gelatin Methacrylate Hydrogels for Enhanced Muscle Tissue Regeneration
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 29, 2025
Abstract
Skeletal
muscle
diseases
like
myopathies
and
muscular
dystrophies
present
significant
clinical
challenges
with
few
effective
treatments.
To
better
understand
disease
mechanisms
accelerate
therapy
development,
robust
in
vitro
models
are
needed.
Extrusion-
light-based
bioprinting
offer
precise
fabrication
of
tissue-like
constructs,
but
creating
bioinks
that
support
cell
function
remains
difficult.
Here,
we
report
a
novel
bioink
which
taurine
is
first
methacrylated—substituting
its
–NH
2
groups
to
afford
methacrylate
(TMA)—enabling
covalent
integration
into
gelatin
methacryloyl
(GelMA)
networks.
We
systematically
compared
GelMA-Taur
(physical
blend)
versus
GelMA-TMA
(covalent)
hydrogels,
assessing
mechanical
stiffness,
swelling
behavior,
photocrosslinking
kinetics.
Incorporating
TMA
yielded
tighter
crosslinking
control,
minimized
overcure
DLP-printed
features,
improved
shape
fidelity.
SEM
revealed
finer
pore
structures
homogeneous
distribution,
release
assays
confirmed
prolonged
retention
rapidly
leaching
taurine.
Photopatterning
3D
printing
complex
geometries
demonstrated
excellent
printability
the
bioink.
Finally,
C2C12
myoblasts
encapsulated
scaffolds
exhibited
accelerated
early
differentiation,
higher
myosin
heavy
chain
expression,
more
extensive
myotube
formation
than
controls.
Together,
these
results
establish
as
printable,
mechanically
tunable,
biologically
active
platform
for
engineering
skeletal
tissue
modeling
regenerative
applications.
Язык: Английский
A comprehensive review of additively manufactured biomedical titanium-based alloys for bone tissue engineering: Biocorrosion, biomechanical, and biological properties
Journal of Materials Research and Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
Язык: Английский
3D-bioprinted urethral grafts: Revolutionizing urethral stricture treatment
Arab Journal of Urology,
Год журнала:
2025,
Номер
unknown, С. 1 - 11
Опубликована: Май 13, 2025
Язык: Английский
Collagen patches releasing phosphatidylserine liposomes guide M1-to-M2 macrophage polarization and accelerate simultaneous bone and muscle healing
Acta Biomaterialia,
Год журнала:
2024,
Номер
187, С. 51 - 65
Опубликована: Авг. 17, 2024
Язык: Английский
Mechanical Stimulation and Aligned Poly(ε-caprolactone)–Gelatin Electrospun Scaffolds Promote Skeletal Muscle Regeneration
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(10), С. 6430 - 6440
Опубликована: Окт. 4, 2024
The
current
treatments
to
restore
skeletal
muscle
defects
present
several
injuries.
creation
of
scaffolds
and
implant
that
allow
the
regeneration
this
tissue
is
a
solution
reaching
researchers'
interest.
To
achieve
this,
electrospinning
useful
technique
manufacture
with
nanofibers
different
orientation.
In
work,
polycaprolactone
gelatin
solutions
were
tested
fabricate
electrospun
two
degrees
alignment
between
their
fibers:
random
aligned.
These
can
be
seeded
myoblast
C2C12
then
stimulated
mechanical
bioreactor
mimics
physiological
conditions
tissue.
Cell
viability
as
well
cytoskeletal
morphology
functionality
was
measured.
Myotubes
in
aligned
(9.84
±
1.15
μm)
thinner
than
(11.55
3.39
μm;
Язык: Английский