MITOCHONDRIAL TRANSPLANTATION FOR THE TREATMENT OF ALZHEIMER'S DISEASE (REVIEW) DOI

D. Y. Zhdanova,

A.V. Chaplygina

Problems of Biological Medical and Pharmaceutical Chemistry, Год журнала: 2023, Номер unknown, С. 60 - 65

Опубликована: Ноя. 1, 2023

Alzheimer's disease (AD) is the most common form of dementia that primarily affects older adults and often begins with memory loss followed by progressive impairment behavioral cognitive functions. Despite fact main pathological signs AD are considered to be extracel-lular deposits beta-amyloid in amyloid plaques intracellular accumulation hyperphosphorylated tau protein neurofi-brillary tangles, recently more attention at cellular molecular levels has been paid other important processes accompanying de-velopment disease. In modern research neurodegenerative diseases, role mitochondria receiving increasing interest. The mitochon-drial cascade hypothesis suggests mitochondrial dysfunction plays a key progression these processes. Recent re-search shows cells have ability exchange among themselves. This process, known as horizontal transfer, al-lows both healthy damaged or dysfunctional mitochondria, moving them from one cell another for further repair degrada-tion, which raises possibility using transplantation therapy diseases. this article, we consider two aspects: transfer transplantation. Horizontal opens new horizons understanding communication interactions. methods discussed article presented described detail. Additionally, review relevance innovative nature transplantation, procedure transferred organs mitochondria. We will discuss various their potential applications medicine. provide information on perspectives field biology therapeutics, expanding function living organisms.

Язык: Английский

Considerations for Developing Mitochondrial Transplantation Techniques for Individualized Medicine DOI Creative Commons
Kit Neikirk,

Dominique C. Stephens,

Heather K. Beasley

и другие.

BioTechniques, Год журнала: 2024, Номер 76(4), С. 125 - 134

Опубликована: Фев. 29, 2024

Tweetable abstract Mitochondrial transplantation has been used to treat various diseases associated with mitochondrial dysfunction. Here, we highlight the considerations in quality control mechanisms that should be considered context of transplantation.

Язык: Английский

Процитировано

6
Emerging Role of Mesenchymal Stromal Cell and Exosome Therapies in Treating Cognitive Impairment DOI Creative Commons

Vick Key Tew,

Muttiah Barathan, Fazlina Nordin

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 284 - 284

Опубликована: Фев. 20, 2025

Cognitive aging, characterized by the gradual decline in cognitive functions such as memory, attention, and problem-solving, significantly impacts daily life. This is often accelerated neurodegenerative diseases, particularly Alzheimer’s Disease (AD) Parkinson’s (PD). AD marked accumulation of amyloid-beta plaques tau tangles, whereas PD involves degeneration dopaminergic neurons. Both conditions lead to severe impairment, greatly diminishing quality life for affected individuals. Recent advancements regenerative medicine have highlighted mesenchymal stromal cells (MSCs) their derived exosomes promising therapeutic options. MSCs possess regenerative, neuroprotective, immunomodulatory properties, which can promote neurogenesis, reduce inflammation, support neuronal health. Exosomes, nanosized vesicles from MSCs, provide an efficient means delivering bioactive molecules across blood–brain barrier, targeting underlying pathologies PD. While these therapies hold great promise, challenges variability MSC sources, optimal dosing, effective delivery methods need be addressed clinical application. The development robust protocols, along with rigorous trials, crucial validating safety efficacy exosome therapies. Future research should focus on overcoming barriers, optimizing treatment strategies, exploring integration lifestyle interventions. By addressing challenges, MSC- exosome-based could offer transformative solutions improving outcomes enhancing individuals aging diseases.

Язык: Английский

Процитировано

0
Mitochondrial transplantation: Triumphs, challenges, and impacts on nuclear genome remodelling DOI Creative Commons
Elly H. Shin, Quinn Le,

Rachel Barboza

и другие.

Mitochondrion, Год журнала: 2025, Номер unknown, С. 102042 - 102042

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Exploring Pyridinium-Based Inhibitors of Cholinesterases: A Review of Synthesis, Efficacy, and Structural Insights DOI Creative Commons
Efraín Polo-Cuadrado,

Rojas-Peña Cristian,

A. Krogfelt Karen

и другие.

European Journal of Medicinal Chemistry Reports, Год журнала: 2025, Номер unknown, С. 100270 - 100270

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Chitosan/PLA-loaded Magnesium oxide nanocomposite to attenuate oxidative stress, neuroinflammation and neurotoxicity in rat models of Alzheimer's disease DOI
Manickam Rajkumar,

Prabha Govindaraj,

Karuppaiya Vimala

и другие.

Metabolic Brain Disease, Год журнала: 2023, Номер 39(4), С. 487 - 508

Опубликована: Дек. 12, 2023

Язык: Английский

Процитировано

7
Nasal administration of mitochondria relieves depressive- and anxiety-like behaviors in male mice exposed to restraint stress through the suppression ROS/NLRP3/caspase-1/IL-1β signaling pathway DOI

Vida Mafikandi,

Fatemehsadat Seyedaghamiri,

Naeimeh Hosseinzadeh

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 28, 2024

Язык: Английский

Процитировано

1
Mitochondrial Transfer in the Neurovascular Unit, Not Only for Energy Rescue: A Systematic Review DOI Creative Commons

Daqiang Zhou,

Sibo Yang,

Jiehong Wu

и другие.

Aging and Disease, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Despite substantial evidence highlighting molecular communication within the components of neurovascular units (NVU), interactions at organelle level have been insufficiently explored in recent decades. Mitochondria, for instance, beyond their traditional role as energy supply intracellular metabolism and survival, provide a novel perspective on intercellular connections through mitochondrial transfer. These transferred mitochondria not only carry bioactive molecules but also signal to mitigate risks both healthy pathological conditions. In this review, we summarized transfer events, relevant routes, underlying mechanisms originating from diverse cell populations NVU. We particularly focus therapeutic potential mechanism treating central nervous system disorders, notably neurodegenerative diseases marked by dysfunction then highlight promising prospects exogenous supplementation treatment target.

Язык: Английский

Процитировано

0
Chitosan/PLA-loaded Magnesium oxide nanocomposite to attenuate oxidative stress, neuroinflammation, and neurotoxicity in rat models of Alzheimer's disease DOI
Manickam Rajkumar,

Prabha Govindaraj,

Karuppaiya Vimala

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Окт. 31, 2023

Abstract Alzheimer's disease (AD) is a neurodegenerative characterized by amyloid-beta (Aβ) aggregation, neuroinflammation, oxidative stress, and dysfunction in the mitochondria cholinergic system. In this study, synthesis of chitosan-polylactic acid-loaded magnesium oxide nanocomposite (CH/PLA/MgONCs) was examined using green precipitation method. The synthesized CH/PLA/MgONCs were confirmed UV-Vis spectrum, FT-IR, SEM-EDAX, physical properties. experiments carried out male Wistar rats injecting streptozotocin (STZ) bilaterally into brain's ventricles through intracerebroventricular (ICV) route at dose 3 mg/kg. We also evaluated effects doses 10 To assess cognitive induced ICV-STZ, we performed behavioral, biochemical, histopathological analyses. our study results, spectrum analysis showed 285 nm, FT-IR analyses that various functional groups present, SEM-EDAX cauliflower-like spherical shape, Mg O present. Treatment with (10 mg/kg) significant improvement spatial non-spatial memory functions. This further supported biochemical showing improved antioxidant enzyme (GSH, SOD, CAT, GPx activity) activities significantly attenuated activity stress. CH/PLA/MgONCs-treated group, observed mitochondrial complex activity. ICV-STZ-induced as indicated increased levels TNF-α, IL-6, CRP, reduced treatment. Additionally, treated histological results healthy neuronal cells brain. Furthermore, silico studies confirm these molecules have good binding affinity inhibit Aβ aggregation. conclusion, treatment reversed AD pathology improving reducing dysfunction. These findings recommend are possible therapeutic agents to treat AD.

Язык: Английский

Процитировано

0
MITOCHONDRIAL TRANSPLANTATION FOR THE TREATMENT OF ALZHEIMER'S DISEASE (REVIEW) DOI

D. Y. Zhdanova,

A.V. Chaplygina

Problems of Biological Medical and Pharmaceutical Chemistry, Год журнала: 2023, Номер unknown, С. 60 - 65

Опубликована: Ноя. 1, 2023

Alzheimer's disease (AD) is the most common form of dementia that primarily affects older adults and often begins with memory loss followed by progressive impairment behavioral cognitive functions. Despite fact main pathological signs AD are considered to be extracel-lular deposits beta-amyloid in amyloid plaques intracellular accumulation hyperphosphorylated tau protein neurofi-brillary tangles, recently more attention at cellular molecular levels has been paid other important processes accompanying de-velopment disease. In modern research neurodegenerative diseases, role mitochondria receiving increasing interest. The mitochon-drial cascade hypothesis suggests mitochondrial dysfunction plays a key progression these processes. Recent re-search shows cells have ability exchange among themselves. This process, known as horizontal transfer, al-lows both healthy damaged or dysfunctional mitochondria, moving them from one cell another for further repair degrada-tion, which raises possibility using transplantation therapy diseases. this article, we consider two aspects: transfer transplantation. Horizontal opens new horizons understanding communication interactions. methods discussed article presented described detail. Additionally, review relevance innovative nature transplantation, procedure transferred organs mitochondria. We will discuss various their potential applications medicine. provide information on perspectives field biology therapeutics, expanding function living organisms.

Язык: Английский

Процитировано

0