Abstract
Mobile
devices
play
a
key
role
in
developing
mental
health
focused
applications
for
individuals.
The
presented
research
proposes
using
mobile
to
limit
the
occurrence
of
depression
disabled
It
novel
two
stage
solution
that
limits
subscribers.
is
integrated
headband.
Disabled
subscribers
have
been
considered
because
their
limited
ability
(or
inability)
demonstrate
motor
skills
enabling
them
avoid
trauma
triggering
scenarios.
also
examines
how
proposed
mechanism
influences
an
individual’s
identity.
This
existing
utilize
invasive
approach
while
non-invasive.
Analysis
shows
preserves
individual
identity
by
74.2%–99.3%
on
average.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 18, 2024
Abstract
To
report
the
results
of
‘responsive’
deep
brain
stimulation
(DBS)
for
Tourette
syndrome
(TS)
in
a
National
Institutes
Health
funded
experimental
cohort.
The
use
‘brain
derived
physiology’
as
method
to
trigger
DBS
devices
deliver
trains
electrical
is
proposed
approach
address
paroxysmal
motor
and
vocal
tic
symptoms
which
appear
part
TS.
Ten
subjects
underwent
bilateral
staged
surgery
each
was
implanted
with
centromedian
thalamic
(CM)
region
leads
M1
cortical
strips.
A
series
identical
experiments
data
collections
were
conducted
on
three
groups
consecutively
recruited
subjects.
Group
1
(n
=
2)
acute
responsive
using
superficial
leads.
2
4)
chronic
3
only
primary
outcome
measure
8
calculated
pre-operative
baseline
Yale
Global
Tic
Severity
Scale
(YGTSS)
subscore
compared
6
month
embedded
setting.
responder
study
defined
any
subject
manifesting
≥
30
points
improvement
YGTSS
subscale.
videotaped
Modified
Rush
Rating
(MRVTRS)
secondary
outcome.
Outcomes
collected
at
months
across
different
device
states:
no
stimulation,
conventional
open-loop
stimulation.
experience
programming
methods
applied
captured.
There
10
medication
refractory
TS
enrolled
(5
male
5
female)
4/8
(50%)
eligible
cohort
met
reduction
scale
30%
when
settings.
Proof
concept
observed
all
(acute
responsive,
cortically
triggered
only).
safe
well
tolerated.
power
spectral
changes
associated
tics
occurred
consistently
low
frequency
2–10
Hz
delta-theta-low
alpha
oscillation
range.
highlighted
variety
strategies
employed
achieve
those
used
overcome
induced
artifacts.
also
established
single
lead
triggering
bi-hemispheric
delivery
therapeutic
Responsive
treat
related
through
application
paradigms.
effective
subset
individuals.
this
not
aimed
making
between
comparisons,
but
rather,
adapted
current
state
art
technology.
Overall,
four
variable
clinical
effectiveness.
Cortical
physiology
therapy
limited
by
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 7, 2024
Treatment-resistant
depression
(TRD)
affects
approximately
2.8
million
people
in
the
U.S.
with
estimated
annual
healthcare
costs
of
$43.8
billion.
Deep
brain
stimulation
(DBS)
is
currently
an
investigational
intervention
for
TRD.
We
used
a
decision-analytic
model
to
compare
cost-effectiveness
DBS
treatment-as-usual
(TAU)
Because
this
therapy
not
FDA
approved
or
common
use,
our
goal
was
establish
effectiveness
threshold
that
trials
would
need
demonstrate
be
cost-effective.
Remission
and
complication
rates
were
determined
from
review
relevant
studies.
published
utility
scores
reflect
quality
life
after
treatment.
Medicare
reimbursement
health
economics
data
approximate
costs.
performed
Monte
Carlo
(MC)
simulations
probabilistic
sensitivity
analyses
estimate
incremental
ratios
(ICER;
USD/quality-adjusted
year
[QALY])
at
5-year
time
horizon.
Cost-effectiveness
defined
using
willingness-to-pay
(WTP)
thresholds
$100,000/QALY
$50,000/QALY
moderate
definitive
cost-effectiveness,
respectively.
included
274
patients
across
16
studies
2009-2021
who
underwent
TRD
had
≥12
months
follow-up
inputs.
From
sector
perspective,
non-rechargeable
devices
(DBS-pc)
require
55%
85%
remission,
while
rechargeable
(DBS-rc)
11%
19%
remission
societal
DBS-pc
35%
46%
DBS-rc
8%
10%
will
unlikely
cost-effective
any
horizon
without
transformative
improvements
battery
longevity.
If
≥8-19%
are
achieved,
likely
more
than
TAU
TRD,
further
increasing
beyond
5
years.
NeuroImage,
Год журнала:
2025,
Номер
unknown, С. 121211 - 121211
Опубликована: Апрель 1, 2025
Structural
connectivity
models
of
the
brain
are
commonly
employed
to
identify
pathways
that
directly
activated
during
deep
stimulation
(DBS).
However,
various
connectomes
differ
in
technical
parameters,
parcellation
schemes,
and
methodological
approaches
used
their
construction.
The
goal
this
study
was
compare
quantify
variability
DBS
pathway
activation
predictions
when
using
different
structural
connectomes,
while
identical
electrode
placements
volumes
brain.
We
analyzed
four
example
connectomes:
1)
Horn
normative
connectome
(whole
brain),
2)
Yeh
population-averaged
tract-to-region
atlas
3)
Petersen
histology-based
(subthalamic
focused),
4)
Majtanik
(anterior
thalamus
focused).
simulations
were
performed
with
each
connectome,
at
generalized
locations
for
placement:
subthalamic
nucleus,
anterior
nucleus
thalamus,
ventral
capsule,
intermediate
thalamus.
choice
resulted
notably
distinct
predictions,
quantitative
analysis
indicated
little
congruence
predicted
patterns
network
connectivity.
tractography-based
provided
estimates
any
location
brain,
but
have
limitations
anatomical
validity.
more
anatomically
realistic,
only
applicable
specific
targets
because
limited
representation
pathways.
widely
varying
inconsistent
inferences
raises
substantial
concern
regarding
general
reliability
connectomic
studies,
especially
those
lack
and/or
electrophysiological
validation
analyses.
Neuropsychiatric Disease and Treatment,
Год журнала:
2024,
Номер
Volume 20, С. 469 - 478
Опубликована: Март 1, 2024
Functional
neurosurgery
involves
modulation
of
activity
within
neural
circuits
that
drive
pathological
activity.
Neurologists
and
neurosurgeons
have
worked
closely
together,
advancing
the
field
for
over
a
century,
such
neurosurgical
procedures
movement
disorders
are
now
accepted
as
"standard
care",
benefiting
hundreds
thousands
patients.
As
with
disorders,
some
neuropsychiatric
illnesses,
including
obsessive
compulsive
disorder
depression,
can
be
framed
networks.
Over
past
two
decades,
evidence
has
accumulated
stereotactic
help
patients
mental
disorders.
Nevertheless,
despite
availability
class
I
interventions,
there
is
huge
mismatch
between
prevalence
severe
refractory
number
referrals
made
to
specialised
functional
services.
This
paper
examines
historical
trajectory
A
review
techniques,
radiofrequency
ablation,
gamma
knife,
deep
brain
stimulation,
magnetic
resonance
imaging
guided
focused
ultrasound,
explains
high
degree
safety
afforded
by
technological
advances
in
field.
Evidence
from
clinical
trials
supporting
presented.
An
improved
understanding
modern
should
foster
collaboration
psychiatry
neurosurgery,
providing
hope
whose
symptoms
all
other
treatments.
Neurotherapeutics,
Год журнала:
2024,
Номер
21(3), С. e00366 - e00366
Опубликована: Апрель 1, 2024
Psychiatric
disorders
are
among
the
leading
contributors
to
global
disease
burden
and
disability.
A
significant
portion
of
patients
with
psychiatric
remain
treatment-refractory
best
available
therapy.
With
insights
from
neurocircuitry
extensive
experience
neuromodulation
deep
brain
stimulation
(DBS)
in
movement
disorders,
DBS
is
increasingly
being
considered
modulate
neural
network
disorders.
Currently,
obsessive-compulsive
disorder
(OCD)
only
U.S.
FDA
(United
States
Food
Drug
Administration)
approved
indication
for
Medically
refractory
depression,
addiction,
other
explored
neuromodulation.
Studies
evaluating
promising
but
lack
larger,
controlled
studies.
This
paper
presents
a
brief
review
current
state
neurosurgical
therapies
OCD
We
also
present
MR-guided
Focused
Ultrasound
(MRgFUS),
novel
form
neuromodulation,
which
can
target
subcortical
structures
similar
DBS,
noninvasive
fashion.
Early
experiences
therapies,
including
MRgFUS
encouraging
disorders;
however,
they
investigational.
VNS
options
properly
selected
cases
respectively.
