Mobile–neural friendly architecture for limiting exposure to traumatic scenes DOI Creative Commons
A. A. Periola, Akintunde Alonge, Kingsley A. Ogudo

et al.

Soft Computing, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract Mobile devices play a key role in developing mental health focused applications for individuals. The presented research proposes using mobile to limit the occurrence of depression disabled It novel two stage solution that limits subscribers. is integrated headband. Disabled subscribers have been considered because their limited ability (or inability) demonstrate motor skills enabling them avoid trauma triggering scenarios. also examines how proposed mechanism influences an individual’s identity. This existing utilize invasive approach while non-invasive. Analysis shows preserves individual identity by 74.2%–99.3% on average.

Language: Английский

Responsive deep brain stimulation for the treatment of Tourette syndrome DOI Creative Commons
Michael S. Okun, Jackson Cagle, Julieth Gomez

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 18, 2024

Abstract To report the results of ‘responsive’ deep brain stimulation (DBS) for Tourette syndrome (TS) in a National Institutes Health funded experimental cohort. The use ‘brain derived physiology’ as method to trigger DBS devices deliver trains electrical is proposed approach address paroxysmal motor and vocal tic symptoms which appear part TS. Ten subjects underwent bilateral staged surgery each was implanted with centromedian thalamic (CM) region leads M1 cortical strips. A series identical experiments data collections were conducted on three groups consecutively recruited subjects. Group 1 (n = 2) acute responsive using superficial leads. 2 4) chronic 3 only primary outcome measure 8 calculated pre-operative baseline Yale Global Tic Severity Scale (YGTSS) subscore compared 6 month embedded setting. responder study defined any subject manifesting ≥ 30 points improvement YGTSS subscale. videotaped Modified Rush Rating (MRVTRS) secondary outcome. Outcomes collected at months across different device states: no stimulation, conventional open-loop stimulation. experience programming methods applied captured. There 10 medication refractory TS enrolled (5 male 5 female) 4/8 (50%) eligible cohort met reduction scale 30% when settings. Proof concept observed all (acute responsive, cortically triggered only). safe well tolerated. power spectral changes associated tics occurred consistently low frequency 2–10 Hz delta-theta-low alpha oscillation range. highlighted variety strategies employed achieve those used overcome induced artifacts. also established single lead triggering bi-hemispheric delivery therapeutic Responsive treat related through application paradigms. effective subset individuals. this not aimed making between comparisons, but rather, adapted current state art technology. Overall, four variable clinical effectiveness. Cortical physiology therapy limited by

Language: Английский

Citations

7
Definition of Implanted Neurological Device Abandonment DOI Creative Commons
Michael S. Okun,

Timothy Marjenin,

Jinendra Ekanayake

et al.

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(4), P. e248654 - e248654

Published: April 30, 2024

Establishing a formal definition for neurological device abandonment has the potential to reduce or prevent occurrence of this abandonment.

Language: Английский

Citations

6
Explainable and Responsible AI in Neuroscience DOI Open Access
Phool Chandra, Himanshu Sharma, Neetu Sachan

et al.

Published: March 3, 2025

Citations

0
Comparison of Structural Connectomes for Modeling Deep Brain Stimulation Pathway Activation DOI Creative Commons
Ketan Mehta, Angela M. Noecker, Cameron C. McIntyre

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121211 - 121211

Published: April 1, 2025

Structural connectivity models of the brain are commonly employed to identify pathways that directly activated during deep stimulation (DBS). However, various connectomes differ in technical parameters, parcellation schemes, and methodological approaches used their construction. The goal this study was compare quantify variability DBS pathway activation predictions when using different structural connectomes, while identical electrode placements volumes brain. We analyzed four example connectomes: 1) Horn normative connectome (whole brain), 2) Yeh population-averaged tract-to-region atlas 3) Petersen histology-based (subthalamic focused), 4) Majtanik (anterior thalamus focused). simulations were performed with each connectome, at generalized locations for placement: subthalamic nucleus, anterior nucleus thalamus, ventral capsule, intermediate thalamus. choice resulted notably distinct predictions, quantitative analysis indicated little congruence predicted patterns network connectivity. tractography-based provided estimates any location brain, but have limitations anatomical validity. more anatomically realistic, only applicable specific targets because limited representation pathways. widely varying inconsistent inferences raises substantial concern regarding general reliability connectomic studies, especially those lack and/or electrophysiological validation analyses.

Language: Английский

Citations

0
Cost-effectiveness and threshold analysis of deep brain stimulation vs. treatment-as-usual for treatment-resistant depression DOI Creative Commons
Katherine E. Kabotyanski, Ricardo A. Najera, Garrett P. Banks

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 7, 2024

Treatment-resistant depression (TRD) affects approximately 2.8 million people in the U.S. with estimated annual healthcare costs of $43.8 billion. Deep brain stimulation (DBS) is currently an investigational intervention for TRD. We used a decision-analytic model to compare cost-effectiveness DBS treatment-as-usual (TAU) Because this therapy not FDA approved or common use, our goal was establish effectiveness threshold that trials would need demonstrate be cost-effective. Remission and complication rates were determined from review relevant studies. published utility scores reflect quality life after treatment. Medicare reimbursement health economics data approximate costs. performed Monte Carlo (MC) simulations probabilistic sensitivity analyses estimate incremental ratios (ICER; USD/quality-adjusted year [QALY]) at 5-year time horizon. Cost-effectiveness defined using willingness-to-pay (WTP) thresholds $100,000/QALY $50,000/QALY moderate definitive cost-effectiveness, respectively. included 274 patients across 16 studies 2009-2021 who underwent TRD had ≥12 months follow-up inputs. From sector perspective, non-rechargeable devices (DBS-pc) require 55% 85% remission, while rechargeable (DBS-rc) 11% 19% remission societal DBS-pc 35% 46% DBS-rc 8% 10% will unlikely cost-effective any horizon without transformative improvements battery longevity. If ≥8-19% are achieved, likely more than TAU TRD, further increasing beyond 5 years.

Language: Английский

Citations

2
Electrical Stimulation for Stem Cell-Based Neural Repair: Zapping the Field to Action DOI Creative Commons

Stephanie N. Iwasa,

Xilin Liu, Hani E. Naguib

et al.

eNeuro, Journal Year: 2024, Volume and Issue: 11(9), P. ENEURO.0183 - 24.2024

Published: Sept. 1, 2024

Language: Английский

Citations

2
Severe Refractory Obsessive Compulsive Disorder and Depression: Should We Consider Stereotactic Neurosurgery? DOI Creative Commons
Ludvic Zrinzo

Neuropsychiatric Disease and Treatment, Journal Year: 2024, Volume and Issue: Volume 20, P. 469 - 478

Published: March 1, 2024

Functional neurosurgery involves modulation of activity within neural circuits that drive pathological activity. Neurologists and neurosurgeons have worked closely together, advancing the field for over a century, such neurosurgical procedures movement disorders are now accepted as "standard care", benefiting hundreds thousands patients. As with disorders, some neuropsychiatric illnesses, including obsessive compulsive disorder depression, can be framed networks. Over past two decades, evidence has accumulated stereotactic help patients mental disorders. Nevertheless, despite availability class I interventions, there is huge mismatch between prevalence severe refractory number referrals made to specialised functional services. This paper examines historical trajectory A review techniques, radiofrequency ablation, gamma knife, deep brain stimulation, magnetic resonance imaging guided focused ultrasound, explains high degree safety afforded by technological advances in field. Evidence from clinical trials supporting presented. An improved understanding modern should foster collaboration psychiatry neurosurgery, providing hope whose symptoms all other treatments.

Language: Английский

Citations

1
Neurosurgical neuromodulation therapy for psychiatric disorders DOI Creative Commons
Manish Ranjan, James J. Mahoney, Ali R. Rezai

et al.

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(3), P. e00366 - e00366

Published: April 1, 2024

Psychiatric disorders are among the leading contributors to global disease burden and disability. A significant portion of patients with psychiatric remain treatment-refractory best available therapy. With insights from neurocircuitry extensive experience neuromodulation deep brain stimulation (DBS) in movement disorders, DBS is increasingly being considered modulate neural network disorders. Currently, obsessive-compulsive disorder (OCD) only U.S. FDA (United States Food Drug Administration) approved indication for Medically refractory depression, addiction, other explored neuromodulation. Studies evaluating promising but lack larger, controlled studies. This paper presents a brief review current state neurosurgical therapies OCD We also present MR-guided Focused Ultrasound (MRgFUS), novel form neuromodulation, which can target subcortical structures similar DBS, noninvasive fashion. Early experiences therapies, including MRgFUS encouraging disorders; however, they investigational. VNS options properly selected cases respectively.

Language: Английский

Citations

1
The Physiologic Basis of Neuromodulation DOI

Tommy J. Wilson,

Ankur Butala

Advances in Psychiatry and Behavioral Health, Journal Year: 2024, Volume and Issue: 4(1), P. 57 - 69

Published: Aug. 6, 2024

Language: Английский

Citations

1
Clinician perspectives on levels of evidence and oversight for deep brain stimulation for treatment-resistant childhood OCD DOI Creative Commons
Michelle Pham,

Tiffany Campbell,

Natalie Dorfman

et al.

Journal of Obsessive-Compulsive and Related Disorders, Journal Year: 2023, Volume and Issue: 39, P. 100830 - 100830

Published: Aug. 23, 2023

Language: Английский

Citations

2