Effects of skull properties on continuous-wave transcranial focused ultrasound transmission DOI

Han Li,

Isla R. M. Barnard,

Tyler Halliwell

и другие.

The Journal of the Acoustical Society of America, Год журнала: 2025, Номер 157(4), С. 2336 - 2349

Опубликована: Апрель 1, 2025

Transcranial low-intensity focused ultrasound can deliver energy to the brain in a minimally invasive manner for neuromodulation applications. However, continuous sonication through skull introduces significant wave interactions, complicating precise delivery target. This study presents comprehensive examination of intracranial acoustic fields generated by transducers and assesses characteristics cranial bone that affect transmission. Acoustic field maps were at 88 regions interest across 10 historical 2 Thiel-embalmed human specimens with frequencies 220, 650, 1000 kHz. The average peak pressure insertion losses skulls 3.6 ± 3.4, 9.3 3.3, 14.8 5.8 dB, respectively, Thiel skulls, respective 2.9 1.8, 9.4 2.6, 17.0 5.5 dB. effects thickness, density ratio, curvature on pressure, power, focal area investigated linear fits produced. Several unfavorable focusing performances observed excessive thickness variation. angulation spacing between transducer also investigated. Preliminary findings indicate superposition resulting from could lead 30%-40% uncertainty recorded pressure.

Язык: Английский

Biophysical effects and neuromodulatory dose of transcranial ultrasonic stimulation. DOI
Tulika Nandi, Benjamin R. Kop, Kasra Naftchi-Ardebili

и другие.

Brain stimulation, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

2
Cross-Species Characterization of Transcranial Ultrasound Propagation DOI Creative Commons
Zhiwei Li, Hanwen Wang, Xiaoyu Zhang

и другие.

Brain stimulation, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Spinal Cord Ultrasound Stimulation Modulates Corticospinal Excitability DOI Creative Commons
Lin Hou, Yuming Lei

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Abstract Background Low-intensity focused ultrasound (LIFU) offers superior tissue penetration and enables precise neuromodulation of cortical subcortical circuits. However, its effects on neural activity in the human spinal cord remain largely unexplored. Objective To investigate LIFU under varying conditions intensity (spatial-peak pulse-average intensity, I SPPA ), duty cycle (DC), pulse repetition frequency (PRF). Methods Thirty-six healthy volunteers participated study. A 500 kHz transducer with a focal depth exceeding 100 mm was used to target C8 cord. Transcranial magnetic stimulation (TMS) applied primary motor cortex (M1) hotspot corresponding first dorsal interosseous (FDI) muscle, innervated by nerve. ms-duration delivered 400 ms prior single-pulse TMS over FDI hotspot. Spinal (SCUS) administered acoustic parameters: intensities (I : 2.5 10 W/cm²), DCs (10% 30%), PRFs (500 1000 Hz). Changes corticospinal excitability were assessed comparing TMS-elicited motor-evoked potentials (MEPs) between active sham SCUS conditions. Results an W/cm², DC 30%, PRF Hz significantly reduced MEP amplitudes compared stimulation. at high 10% 30% did not affect amplitudes. Additionally, while decreased produce significant changes. Conclusions The results indicate that can suppress drive muscles, especially when utilizing parameters. This suggests may provide novel method for modulating activity.

Язык: Английский

Процитировано

0
Advancements and prospects of transcranial focused ultrasound in pain neuromodulation DOI
Yu Shi, Wen Wu

Pain, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Transcranial focused ultrasound (tFUS) is an emerging noninvasive neuromodulation technology that has shown great potential in pain modulation. This review systematically elucidates the multilevel biological mechanisms of tFUS neuromodulation, from network-wide effects to cellular and molecular processes, as well broader systemic influences. Preliminary animal model studies have revealed tFUS's ability improve behavioral indicators modulate neural circuit activity under pathological conditions. A small number clinical also suggest may certain benefits improving symptom experience emotional state chronic patients. However, current research generally limitations such sample sizes short follow-up periods. More high-quality are needed verify long-term safety treatment. Overcoming these advancing large-scale translational will help fully exploit application precision medicine provide new treatment options for relief.

Язык: Английский

Процитировано

0
Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation DOI Creative Commons
Benjamin R. Kop,

Linda de Jong,

Kim Butts Pauly

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Transcranial ultrasonic stimulation (TUS) redefines what is possible with non-invasive neuromodulation by oaering unparalleled spatial precision and flexible targeting capabilities. However, peripheral confounds pose a significant challenge to reliably implementing this technology. While auditory during TUS have been studied extensively, the somatosensory confound has overlooked thus far. It will become increasingly vital quantify manage as field shifts towards higher doses, more compact devices, frequent through temple where co-stimulation pronounced. Here, we provide systematic characterisation of TUS. We also identify conditions under which can be mitigated most eaectively mapping confound-parameter space. Specifically, investigate dose-response eaects, pulse shaping characteristics, transducer-specific parameters. demonstrate that avoiding near-field intensity peaks in scalp, spreading energy across greater area ramping envelope, delivering equivalent doses via longer, lower-intensity pulses rather than shorter, higher-intensity pulses. Additionally, repetition frequencies fundamental reduce eaects. Through our parameter space, find preliminary evidence particle displacement (strain) may primary biophysical driving force behind co-stimulation. This study provides actionable strategies minimise confounds, support thorough experimental control required unlock full potential for scientific research clinical interventions. Tactile, thermal, even painful occur TUS.Confounds & parameters.Valid replicable requires confounds.Particle confounds.

Язык: Английский

Процитировано

0
Response to ‘Safety Considerations for Transcranial Ultrasound Stimulation: A Comment on Nandi et al.’ DOI Creative Commons
Tulika Nandi, Benjamin R. Kop,

Kim Butts Pauly

и другие.

Brain stimulation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Low-intensity transcranial ultrasound stimulation and its regulatory effect on pain DOI
Yuxi Liu, Xinyuan Tian, Long Chen

и другие.

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Safety considerations for transcranial ultrasound stimulation: A comment on Nandi et al. DOI Creative Commons
Jean‐François Nankoo,

Massimo Pascuzzi,

Robert Chen

и другие.

Brain stimulation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Effects of skull properties on continuous-wave transcranial focused ultrasound transmission DOI

Han Li,

Isla R. M. Barnard,

Tyler Halliwell

и другие.

The Journal of the Acoustical Society of America, Год журнала: 2025, Номер 157(4), С. 2336 - 2349

Опубликована: Апрель 1, 2025

Transcranial low-intensity focused ultrasound can deliver energy to the brain in a minimally invasive manner for neuromodulation applications. However, continuous sonication through skull introduces significant wave interactions, complicating precise delivery target. This study presents comprehensive examination of intracranial acoustic fields generated by transducers and assesses characteristics cranial bone that affect transmission. Acoustic field maps were at 88 regions interest across 10 historical 2 Thiel-embalmed human specimens with frequencies 220, 650, 1000 kHz. The average peak pressure insertion losses skulls 3.6 ± 3.4, 9.3 3.3, 14.8 5.8 dB, respectively, Thiel skulls, respective 2.9 1.8, 9.4 2.6, 17.0 5.5 dB. effects thickness, density ratio, curvature on pressure, power, focal area investigated linear fits produced. Several unfavorable focusing performances observed excessive thickness variation. angulation spacing between transducer also investigated. Preliminary findings indicate superposition resulting from could lead 30%-40% uncertainty recorded pressure.

Язык: Английский

Процитировано

0