Geochemical Insights into Health Risks from Potentially Toxic Elements in Rural Aqueducts of Cocle, Panama: Unveiling Links to Local Geology
Water,
Год журнала:
2025,
Номер
17(1), С. 110 - 110
Опубликована: Янв. 3, 2025
The
El
Valle
Volcanic
Complex,
located
in
the
province
of
Cocle,
Panama,
presents
geological
characteristics
that
could
be
linked
to
public
health
problems.
This
study
focuses
on
municipalities
San
Juan
de
Dios,
Pajonal,
and
Caballero,
where
water
is
consumed
directly
from
springs
(groundwater
outcrops).
region
has
a
high
incidence
non-traditional
chronic
kidney
disease
(nt-CKD)
may
associated
with
natural
presence
potentially
toxic
elements
(PTEs)
water.
aimed
analyze
concentration
PTEs
groundwater
assess
carcinogenic
(CR)
non-carcinogenic
(HQ)
risk
human
direct
ingestion
Sediments,
rocks,
samples
were
collected.
Major
ions
(As,
Al,
Ba,
Co,
Cu,
Fe,
Mn,
Sr,
Sb,
Pb,
V,
Zn)
measured,
mineralogical
composition
rocks
was
analyzed.
results
showed
Fe
only
PTE
exceeded
recommended
for
drinking
water,
according
Panama
regulations,
Pb
USEPA.
In
Caballero
acceptable
threshold
CR
HQ
exceeded,
higher
percentage
than
Dios.
contribute
most
are
As.
suggests
region’s
historical
volcanic
activity,
involving
release
minerals
rich
these
PTEs,
along
interaction
between
contributing
phenomenon
what
led
prolonged
exposure
elements,
which
correlates
prevalence
area.
novel
study,
first
conducted
as
it
seeks
uncover
relationship
geology
site,
consumption,
implication
risks,
aim
generating
new
information
decision
makers
generation
policies
issues
such
nt-CKD
cancer
region.
Язык: Английский
Removal of Pb2+from Aqueous Media by Solidago canadensis L.-Derived and Crab Shell-Derived Biochar: Adsorption Behavior and Optimization of Adsorption Conditions
Water Air & Soil Pollution,
Год журнала:
2025,
Номер
236(2)
Опубликована: Янв. 7, 2025
Язык: Английский
Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1
Future Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
11(1)
Опубликована: Янв. 14, 2025
Abstract
Background
Lead
(Pb)
is
a
heavy
metal
with
extreme
toxicity
and
numerous
industrial
uses.
It
produces
nephrotoxicity
notable
changes
in
renal
architecture
function.
The
Alhagi
maurorum
(AM)
belongs
to
the
family
Fabaceae
native
Middle
East
area.
In
present
study,
potential
nephroprotective
effects
of
AM
Pb-intoxicated
rats
were
evaluated.
Results
methanolic
extract
was
standardized
reference
its
main
phenolic
compounds
orientin,
rutin,
quercetin.
Acute
oral
studies
indicated
that
safe
for
animals.
Rats
allocated
into
five
groups
treated
28
days
as
follows:
control,
(200
mg/kg,
orally),
Pb
(15
+
(100
mg/kg),
mg/kg).
administration
markedly
increased
serum
cystatin
C,
urea,
creatinine
levels,
urinary
NAG.
also
caused
histopathological
alterations.
However,
o-treatment
ameliorated
such
pathological
changes.
addition,
treatment
prevented
Pb-induced
accumulation
malondialdehyde
(MDA),
attenuated
glutathione
(GSH)
depletion,
catalase
(CAT)
superoxide
dismutase
(SOD)
exhaustion.
guarded
against
enhanced
protein
expression
interleukin-6
(IL-6),
tumor
necrosis
factor-alpha
(TNF-α),
cyclooxygenase-2
(COX-2),
nuclear
factor-kappa
B
(NF-κB).
Further,
significantly
upregulation
mRNA
levels
Bax
downregulation
Bcl-2.
These
associated
heme
oxygenase-1
(HO-1)
factor
erythroid
2-related
2
(Nrf2)
tissue.
Conclusion
guards
involve,
at
least
partly,
antioxidant,
anti-inflammatory,
anti-apoptotic
activities
well
modulation
HO-1
Nrf2
expression.
Язык: Английский
Dopamine and 24-Epibrassinolide Upregulate Root Resilience, Mitigating Lead Stress on Leaf Tissue and Stomatal Performance in Tomato Plants
Agronomy,
Год журнала:
2025,
Номер
15(1), С. 239 - 239
Опубликована: Янв. 18, 2025
Soil
contamination
linked
to
anthropogenic
activities
has
become
a
serious
environmental
problem
on
global
scale.
It
is
caused
by
heavy
metals,
such
as
lead
(Pb).
Dopamine
(DOP)
biogenic
amine
that
acts
neurotransmitter.
found
in
plant
organs
and
induces
tolerance
against
abiotic
stresses,
including
contamination.
24-epibrassinolide
(EBR)
stimulates
metabolism,
positively
impacting
flowering
production.
This
research
aimed
evaluate
whether
EBR
DOP,
applied
alone
or
combined,
can
mitigate
the
impacts
Pb
roots
leaves
measuring
root
leaf
structures
stomatal
behavior.
For
roots,
both
growth
regulators
maximized
epidermis,
with
increases
treatments
Pb2+
−
DOP
+
(45%),
(24%),
(36%),
when
compared
equal
treatment
without
Pb2+.
To
leaves,
tested
molecules
improved
structures,
significantly
increasing
palisade
parenchyma
spongy
parenchyma.
Parallelly,
performance
was
boosted
after
confirmed
increments
density.
Our
study
proved
mitigated
damages
exposed
stress,
but
better
results
were
alone.
Язык: Английский
Mechanistic Insights into Pressmud-Mediated Improvement in Wheat Growth, Quality and Productivity under Lead Contaminated Salt-Affected Soil
Journal of soil science and plant nutrition,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
Язык: Английский
pXRF Skeletal Measurements as an Assessment Tool for Environmental Exposure to Lajes Field–Derived Contaminants (Terceira Island, Azores, Portugal)
Biological Trace Element Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
Abstract
Lajes
Field
is
an
Atlantic
Portuguese
military
air
base
that
has
been
used
by
the
USA
since
Cold
War,
primarily
for
intercontinental
refueling.
For
this
purpose,
large
fuel
tanks
and
extensive
pipeline
network
were
constructed
within
municipality
of
Praia
da
Vitória,
on
Terceira
Island,
Azores.
Over
past
two
decades,
leaks
detected
confirmed
to
have
contaminated
soils
aquifers
supply
water
public
use.
latter,
identified
contaminants
include
TPH,
PAH,
BTEX,
VOCs,
metals.
Although
risk
assessment
reports
unacceptable
risks
human
health,
journalistic
investigations
suggest
unusually
high
cancer
rates,
no
possible
exposure
conducted
date.
To
address
gap,
metals,
serving
as
a
proxy
overall
contamination
exposure,
measured
using
portable
X-ray
fluorescence
(pXRF)
in
First
Identified
Skeletal
Collection
Azores
(CEI/Açores).
A
total
64
skeletons
with
known
places
last
residence
selected
(44
from
Angra
do
Heroísmo,
where
present,
20
present).
No
significant
differences
mean
ages
at
death
observed
between
groups,
sex
distribution
was
similar.
Additionally,
soil
samples
46
graves
analyzed
assess
potential
diagenesis.
Greater
concentrations
Sb,
As,
Cd,
Cr,
Au,
Mo,
Sr,
Sn,
U,
Zr
found
individuals
Vitória
(
p
<
0.05).
Soil
measurements,
Pearson’s
correlation
test,
principal
component
analysis
As
levels
can
be
partially
attributed
remaining
likely
result
other
factors,
including
particularly
Mo.
pioneering
study
contributes
ongoing
discussion
subject,
further
research
should
both
CEI/Açores
living
population
discuss
issue.
Язык: Английский
Environmentally Relevant Lead Exposure Impacts Gene Expression in SH-SY5Y Cells Throughout Neuronal Differentiation
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 3, 2024
Abstract
Lead
(Pb)
causes
learning
and
memory
impairments,
but
the
molecular
effects
of
continuous,
environmentally
relevant
levels
exposure
on
key
neurodevelopmental
processes
are
not
fully
characterized.
Here
we
examine
a
range
Pb
concentrations
(0.16μM,
1.26μM,
10μM
Pb)
relative
to
control
neural
differentiation
in
SH-SY5Y
cell
model.
began
day
5
was
continuous
for
remaining
days,
after
which
assessed
transcriptome
via
RNA
sequencing
at
several
time
points.
The
bulk
detected
changes
gene
expression
occurred
with
condition.
Interestingly,
associated
lower
two
exposures
were
stage-specific,
aberrant
genes
(e.g.,
COL3A1
,
HMOX1
CCL2
)
observed
during
days
9,
12,
15
both
0.16μM
1.26μM
conditions,
disappeared
by
concluded
18.
We
six
co-expression
clusters
differentiation,
10uM
significantly
perturbed
clusters,
one
involved
cycling
DNA
repair
other
protein
synthesis.
Benchmark
concentration
analysis
identified
many
affected
or
below
current
US
standard
(3.5μg/dL)
these
enriched
pathways
including
stress
responses,
repair,
misfolded
response,
mitosis,
neurotransmitter
production.
This
work
highlights
potential
new
mechanisms
impact
throughout
result
long-lasting
implications
health
cognition.
Язык: Английский