Mutation Research/Reviews in Mutation Research, Год журнала: 2019, Номер 781, С. 165 - 174
Опубликована: Май 22, 2019
Язык: Английский
Pharmacological Research, Год журнала: 2022, Номер 186, С. 106549 - 106549
Опубликована: Ноя. 8, 2022
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder which associated with the dysregulation of autoimmune response. In recent years, early diagnosis, aggressive treatment and alternative therapeutic options disease-modifying anti-rheumatic drugs (DMARDs) markedly improve both management long-term prognosis RA. Since discovery non-coding RNA (ncRNA) including microRNA (miRNA), long (lncRNA) others, their altered expressions have been unraveled to be deregulated in various diseases Several lines evidence are emerging that ncRNA may contribute pathogenesis, disease progression For example, SNP rs2850711 within lnc00305 was indicated associate RA development susceptibility, whereas higher level miR-10a represented good response methotrexate (MTX) patients. aspect refractory RA, also plays an important role by affecting or regulating drug sensitivity Of note, lower expression miR-20a rheumatoid synovial fibroblast (RASFs) demonstrated activate Janus Kinase (JAK)- signal transducer activator transcription 3(STAT3)-mediated inflammation, thereby promoting cell proliferation apoptosis-resistant. this review, we illustrated changes ncRNAs underlying mechanisms whole developing period pathogenesis progression, as well highlighted novel targets/strategies bio-markers for therapy.
Язык: Английский
Процитировано
24
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 159, С. 114161 - 114161
Опубликована: Янв. 13, 2023
Exosomes are potent mediators of physiological and pathological processes. In Alzheimer's disease inflammatory disorders, due to exosomes' distinctive ability cross the blood-brain barrier, a bidirectional communication between periphery central nervous system exists. Since exosomes can carry various biochemical molecules, this review investigates role as possible chronic systemic diseases disease. pro-inflammatory molecules generated in periphery, travel system, target glial neuronal cells. Microglia astrocytes then become activated, initiating neuroinflammation. As aging brain is more susceptible such changes, state neuroinflammation stimulate neuropathologies, impair amyloid-beta clearance capabilities, generate dysregulated microRNAs that alter expression genes critical pathology. These processes, individually collectively, significant risk factors for development
Язык: Английский
Процитировано
13
Genes & Diseases, Год журнала: 2025, Номер unknown, С. 101518 - 101518
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
The Journal of Rheumatology, Год журнала: 2019, Номер 47(2), С. 188 - 196
Опубликована: Май 15, 2019
MicroRNA (miRNA) are short noncoding RNA that regulate genes and both biomarkers mediators of disease. We used small (sRNA) sequencing machine learning methodology to develop an miRNA panel reliably differentiate between rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) control subjects.Plasma samples from 167 RA 91 subjects who frequency-matched for age, race, sex were sRNA sequencing. TIGER was analyze miRNA. DESeq2 random forest analyses identify a prioritized list differentially expressed in patients with RA. Prioritized validated by quantitative PCR, lasso logistic regression select the final 6 best differentiated controls. The separate cohort 12 SLE, 32 RA, subjects. Panel efficacy assessed area under receiver operative characteristic curve (AUC) analyses.The included miR-22-3p, miR-24-3p, miR-96-5p, miR-134-5p, miR-140-3p, miR-627-5p. discovery (AUC = 0.81) validation cohorts 0.71), seronegative 0.84), remission 0.85), SLE 0.80) versus Pathway analysis showed upstream regulators targets associated pathways implicated pathogenesis.An identified bioinformatic approach may represent autoimmunity signature, perhaps related inflammatory arthritis, which is not dependent on active disease seropositivity.
Язык: Английский
Процитировано
42
Mutation Research/Reviews in Mutation Research, Год журнала: 2019, Номер 781, С. 165 - 174
Опубликована: Май 22, 2019
Язык: Английский
Процитировано
37