The
use
of
plants
for
the
prevention,
diagnosis,
treatment,
and
improvement
diseases
dates
back
to
antiquity
has
been
widely
employed
in
traditional
medicine.
Among
various
plant
families,
Zingiberaceae
family
garnered
special
attention
due
its
ability
produce
beneficial
bioactive
substances
food,
pharmaceutical,
cosmetic
industries.
A
prominent
member
this
is
Curcuma
longa,
commonly
known
as
turmeric
or
saffron,
which
contains
a
compound
called
curcumin
that
possesses
potential
biopharmacological
activity.
Curcumin
considered
safe
by
American
Food
Drug
Administration
(FDA)
does
not
exhibit
any
side
effects
when
consumed
moderate
amounts.
Numerous
studies
have
conducted
on
therapeutic
diseases,
particularly
neurodegenerative
disorders
such
Alzheimer's
disease.
Research
indicates
substance
holds
remarkable
an
effective
treatment.
In
context,
chapter
focuses
characteristics
C.
longa
reviews
related
treating
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 1597 - 1627
Опубликована: Фев. 1, 2024
Abstract:
The
development
of
numerous
diseases
is
significantly
influenced
by
inflammation.
Macrophage-derived
exosomes
(M-Exos)
play
a
role
in
controlling
inflammatory
reactions
various
conditions,
including
chronic
pain,
hypertension,
and
diabetes.
However,
the
specific
targets
roles
M-Exos
regulating
inflammation
remain
largely
unknown.
This
review
summarizes
current
knowledge
on
biogenesis
provides
updated
information
M-Exos'
biological
function
modulation.
Furthermore,
this
highlights
functionalization
engineering
strategies
M-Exos,
while
providing
an
overview
cutting-edge
approaches
to
advancements
their
application
as
therapeutics
for
Finally,
multiple
mechanisms
are
presented
along
with
perspectives
challenges,
potential
contribution
that
may
have
through
modulation
discussed.
Keywords:
inflammation,
macrophage-derived
exosomes,
functions,
modulation,
Biology,
Год журнала:
2023,
Номер
12(6), С. 788 - 788
Опубликована: Май 30, 2023
AD
is
a
complex,
progressive,
age-related
neurodegenerative
disorder
representing
the
most
common
cause
of
senile
dementia
and
neurological
dysfunction
in
our
elderly
domestic
population.
The
widely
observed
heterogeneity
reflection
complexity
process
itself
altered
molecular-genetic
mechanisms
operating
diseased
human
brain
CNS.
One
key
players
this
complex
regulation
gene
expression
pathological
neurobiology
are
microRNAs
(miRNAs)
that,
through
their
actions,
shape
transcriptome
cells
that
normally
associate
with
very
high
rates
genetic
activity,
transcription
messenger
RNA
(mRNA)
generation.
analysis
miRNA
populations
characterization
abundance,
speciation
can
further
provide
valuable
clues
to
understanding
process,
especially
sporadic
forms
disorder.
Current
in-depth
analyses
high-quality
age-
gender-matched
control
tissues
providing
pathophysiological
miRNA-based
signatures
serve
as
basis
for
expanding
mechanistic
future
design
miRNA-
related
RNA-based
therapeutics.
This
focused
review
will
consolidate
findings
from
multiple
laboratories
which
abundant
species,
both
free
exosome-bound
CNS,
species
appear
be
prominently
affected
by
recent
developments
advancements
signaling
hippocampal
CA1
region
AD-affected
brains.
Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
As
human
life
expectancy
continues
to
rise,
becoming
a
pressing
global
concern,
it
brings
into
focus
the
underlying
mechanisms
of
aging.
The
increasing
lifespan
has
led
growing
elderly
population
grappling
with
age-related
diseases
(ARDs),
which
strains
healthcare
systems
and
economies
worldwide.
While
senescence
was
once
regarded
as
an
immutable
inexorable
phenomenon,
impervious
interventions,
emerging
field
geroscience
now
offers
innovative
approaches
aging,
holding
promise
extending
period
healthspan
in
humans.
Understanding
intricate
links
between
aging
pathologies
is
essential
addressing
challenges
presented
by
populations.
A
substantial
body
evidence
indicates
shared
pathways
contributing
development
progression
various
ARDs.
Consequently,
novel
interventions
targeting
intrinsic
have
potential
delay
onset
diverse
pathological
conditions,
thereby
healthspan.
In
this
narrative
review,
we
discuss
most
promising
methods
aimed
at
modulating
harbor
mitigate
ARDs
future.
We
also
outline
complexity
review
recent
empirical
identify
rational
strategies
for
promoting
healthy
Brain Sciences,
Год журнала:
2023,
Номер
13(7), С. 1104 - 1104
Опубликована: Июль 21, 2023
Sleep
bruxism
(SB)
is
a
sleep-related
behavior
characterized
as
rhythmic
(phasic)
or
non-rhythmic
(tonic)
masticatory
muscle
activity.
SB
common
sleep
with
predominantly
central
origin.
The
aim
of
this
systematic
review
was
to
evaluate
the
relationship
between
inflammatory
status
and
according
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
2020
(PRISMA
2020).
research
registered
at
PROSPERO
(CRD42023395985).
We
performed
literature
analysis
using
five
different
databases.
Furthermore,
backward
snowballing
technique
applied
identify
additional
papers.
Initially,
28
papers
were
screened
from
database
search,
162
revealed
in
process.
Eventually,
articles
included.
Data
concerning
patients
experiencing
investigated
summarized.
Due
heterogeneity
compared
studies,
only
qualitative
comparison
narrative
summary
performed.
results
suggest
that
could
be
associated
systemic
inflammation.
In
fact,
there
are
no
conclusively
showing
bruxers
comparable
non-bruxers.
However,
each
examined
studies
utilized
methods
assessing
inflammation,
which
makes
dubious.
Exosomes,
which
are
small
extracellular
vehicles
produced
by
a
variety
of
cell
types,
have
emerged
as
key
actors
in
intercellular
communication
due
to
their
ability
transport
diverse
payload
proteins,
nucleic
acids,
and
lipids.
This
is
critical
both
normal
pathological
situations,
particularly
the
complicated
terrain
brain
illnesses.
book
chapter
introduces
exosomes
many
actions
inside
central
nervous
system
(CNS).
These
duties
include
crucial
activities
like
cell-to-cell
communication,
waste
disposal,
inflammation
regulation,
neuroprotection.
Exosomes
been
connected
neurological
disorders
such
Alzheimer's
Parkinson's
disease,
where
they
replicate
misfolded
proteins
contribute
disease
progression.
Furthermore,
related
cancer,
promote
tumor
formation
dissemination.
Understanding
concepts
behind
exosome-mediated
diseases
enables
diagnostic
innovation
therapy
progress.
provide
promising
approach
for
biomarker
creation,
with
potential
change
early
detection
monitoring.
targeted
utilization
drug
delivery
brings
up
new
therapeutic
options.
review
focuses
on
roles
CNS
consequences
understanding,
diagnosing,
even
treating
Parkinson's
disease
(PD),
the
second
most
common
neurological
ailment
in
world
after
Alzheimer's
(AD),
affects
about
1%
of
those
over
65
years.
Exosomes
were
first
thought
to
be
useless
cell
debris.
It
has
been
discovered
that
exosomes
contain
a
variety
non-coding
RNAs,
including
microRNAs,
lncRNAs,
and
circRNAs,
as
well
other
bioactive
compounds.
A
few
these
compounds
are
functional
messenger
RNAs
(mRNAs),
certain
proteins,
lipids,
chemicals.
Our
understanding
exosome
function
body
improved
result
this
information.
physiological
activities
show
important
include
migration,
angiogenesis,
intercellular
communication,
anti-tumor
immunity.
can
help
nervous
system's
cells
communicate
with
one
another,
get
rid
waste,
keep
myelin
coating
place.
Similar
this,
it
is
possible
development
central
system
illnesses
like
influenced
by
brain
exosomes.
The
several
neurodegenerative
disorders
(NDD),
mostly
attributed
extracellular
vehicles
(EVs)
known
(EXOs).
As
result,
have
attracted
attention
EVs
pathophysiological
roles.
Because
their
shown
ability
transport
both
pathogenic
therapeutic
cargo,
researchers
altered
EXOs
for
use
drug
delivery.
The
brain
is
a
highly
complex
interconnected
neuronal
network
with
specialized
blood–brain
barrier
(BBB).
BBB
diffusion
crucial
for
protecting
normal
function
by
blocking
dangerous
compounds
from
crossing
the
bloodstream
to
brain;
only
small
molecules
can
cross
BBB.
However,
diseases,
such
as
Alzheimer's
disease,
Parkinson's
seizures,
multiple
sclerosis,
stroke,
and
cancers,
are
some
of
most
dominant,
traumatic,
nevertheless
poorly
treated
diseases.
development
drug
delivery
systems
disorders
has
had
poorest
achievement
rates
compared
other
therapeutic
areas.
Exosomes
extracellular
nanovesicles
consisting
proteins,
messenger
RNAs,
microRNAs.
They
prominent
mediators
intercellular
communication,
regulating,
instructing,
re-educating
their
surrounding
environment
well
targeting
different
organs
through
surface
modifications.
secreted
blood
cells
endothelial
directly
into
circulation
in
response
CNS
pathological
conditions.
Secreted
exosomes
express
markers
offer
track
cellular
origin,
addition
making
them
useful
diagnostic
purposes
disease
treatments.
In
this
book
chapter,
we
have
focused
on
biogenesis
along
functions
contribution
treatment
disorders.
We
end
chapter
an
account
tools
future
prospects
respect
diseases
associated
central
nervous
system.
