Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota

Nutrients, Год журнала: 2023, Номер 15(9), С. 2211 - 2211

Опубликована: Май 6, 2023

Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut homeostasis their deficiency is involved the pathogenesis of several disorders, including inflammatory bowel diseases, colorectal cancer, cardiometabolic disorders. SCFAs are metabolites specific bacterial taxa human microbiota, production influenced by foods or food supplements, mainly prebiotics, direct fostering these taxa. This Review provides an overview SCFAs’ roles functions, SCFA-producing bacteria, from microbiological characteristics taxonomy to biochemical process that lead release SCFAs. Moreover, we will describe potential therapeutic approaches boost levels treat different related diseases.

Язык: Английский

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Targeting the gut microbiota for cancer therapy

Nature reviews. Cancer, Год журнала: 2022, Номер 22(12), С. 703 - 722

Опубликована: Окт. 17, 2022

Язык: Английский

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Postoperative Probiotics Administration Attenuates Gastrointestinal Complications and Gut Microbiota Dysbiosis Caused by Chemotherapy in Colorectal Cancer Patients

Nutrients, Год журнала: 2023, Номер 15(2), С. 356 - 356

Опубликована: Янв. 11, 2023

The current study aims to evaluate the potential roles of taking probiotics postoperatively in attenuating gastrointestinal complications and disturbed gut microbiota colorectal cancer (CRC) patients undergoing chemotherapy. One hundred eligible CRC who were treated with radical surgery needed receive chemotherapy recruited. Half them randomly assigned Probio group take a probiotic combination from post-operation end first chemotherapeutic course. other half placebo instead classified as Placebo group. Gastrointestinal such nausea, acid reflux, abdominal pain, distention, constipation, diarrhea recorded during Fecal samples collected preoperatively after cycle postoperative for 16S rRNA high-throughput sequencing short-chain fatty acids (SCFAs) analysis. Results showed that administration could effectively reduce chemotherapy-induced complications, particularly (p < 0.01). Additionally, also reduced bacterial diversity indexes patients, which be significantly increased by probiotics. Moreover, this caused significant changes composition microbiota, indicated decreased phylum levels Firmicutes Bacteroidetes, Proteobacteria, Verrucomicrobia. In particular, several genera Akkermansia Clostridium increased, while Prevotella, Lactobacillus, Roseburia 0.05). However, restore these taxa both at genus levels, mildly increase Bifidobacterium, Streptococcus, Blautia. Furthermore, promote production SCFAs, increasing acetate, butyrate, propionate 0.0001). These results support beneficial effects interventions novel alternative or complementary strategies chemoprevention.

Язык: Английский

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The Gut Microbial Bile Acid Modulation and Its Relevance to Digestive Health and Diseases

Gastroenterology, Год журнала: 2023, Номер 164(7), С. 1069 - 1085

Опубликована: Фев. 24, 2023

The human gut microbiome has been linked to numerous digestive disorders, but its metabolic products have much less well characterized, in part due the expense of untargeted metabolomics and lack ability process data. In this review, we focused on rapidly expanding information about bile acid repertoire produced by microbiome, including impacts acids a wide range host physiological processes diseases, discussed role short-chain fatty other important microbiome-derived metabolites. Of particular note is action metabolites throughout body, which impact ranging from obesity aging disorders traditionally thought as diseases nervous system, that are now recognized being strongly influenced it produces. We also highlighted emerging for modifying improve health or treat disease, "engineered native bacteria'' approach takes bacterial strains patient, modifies them alter metabolism, reintroduces them. Taken together, study derived provided insights into pathophysiological processes, substantial potential new approaches diagnostics therapeutics disease of, involving, gastrointestinal tract.

Язык: Английский

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New Insights and Potential Therapeutic Interventions in Metabolic Diseases

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10672 - 10672

Опубликована: Июнь 26, 2023

Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development new techniques insights has led to a deeper understanding mechanisms underlying these conditions opened up avenues for diagnosis treatment. In this review, we discussed rise diseases, especially Western countries, genetical, psychological, behavioral basis role nutrition physical activity single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, cell-based therapies diseases. Finally, practical applications derived from information are made.

Язык: Английский

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Colorectal cancer and gut microbiota studies in China

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Июль 23, 2023

Colorectal cancer (CRC) is the third most common malignant tumor worldwide. The incidence and mortality rates of CRC have been increasing in China, possibly due to economic development, lifestyle, dietary changes. Evidence suggests that gut microbiota plays an essential role tumorigenesis CRC. Gut dysbiosis, specific pathogenic microbes, metabolites, virulence factors, microbial carcinogenic mechanisms contribute initiation progression biomarkers potential translational applications screening early diagnosis. microbiota-related interventions could improve anti-tumor therapy's efficacy severe intestinal toxic effects. Chinese researchers made many achievements relationship between CRC, although some challenges remain. This review summarizes current evidence from China on mainly including characteristics, especially Fusobacterium nucleatum Parvimonas micra, which identified be enriched patients; pathogens such as F. enterotoxigenic Bacteroides fragilis, P. scientists extensively studied; diagnostic nucleatum; therapeutic effects, microecological agents represented by certain Lactobacillus strains, fecal transplantation, traditional medicines Berberine Curcumin. More efforts should focused exploring underlying pathogenesis providing novel preventive strategies.

Язык: Английский

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Molecular crosstalk between polyphenols and gut microbiota in cancer prevention

Nutrition Research, Год журнала: 2024, Номер 124, С. 21 - 42

Опубликована: Янв. 27, 2024

Язык: Английский

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Crosstalk between gut microbiotas and fatty acid metabolism in colorectal cancer

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Фев. 26, 2025

Abstract Colorectal cancer (CRC) is the third most common malignancy globally and second leading cause of cancer-related mortality. Its development a multifactorial multistage process influenced by dynamic interplay between gut microbiota, environmental factors, fatty acid metabolism. Dysbiosis intestinal microbiota abnormalities in microbiota-associated metabolites have been implicated colorectal carcinogenesis, highlighting pivotal role microbial metabolic interactions. Fatty metabolism serves as critical nexus linking dietary patterns with activity, significantly impacting health. In CRC patients, reduced levels short-chain acids (SCFAs) SCFA-producing bacteria consistently observed. Supplementation probiotics has demonstrated tumor-suppressive effects, while therapeutic strategies aimed at modulating SCFA shown potential enhancing efficacy radiation therapy immunotherapy both preclinical clinical settings. This review explores intricate relationship metabolism, CRC, offering insights into underlying mechanisms their translational applications. Understanding this could pave way for novel diagnostic, therapeutic, preventive management CRC.

Язык: Английский

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Integrated Analysis of Colorectal Cancer Reveals Cross-Cohort Gut Microbial Signatures and Associated Serum Metabolites

Gastroenterology, Год журнала: 2022, Номер 163(4), С. 1024 - 1037.e9

Опубликована: Июль 2, 2022

Язык: Английский

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The gut-lung axis in severe acute Pancreatitis-associated lung injury: The protection by the gut microbiota through short-chain fatty acids

Pharmacological Research, Год журнала: 2022, Номер 182, С. 106321 - 106321

Опубликована: Июнь 22, 2022

The role of gut microbiota in regulating the intestinal homeostasis, as well pathogenesis severe acute pancreatitis-associated lung injury (PALI) is widely recognized. bioactive functions metabolites with small molecule weight and detail molecular mechanisms PALI mediated by "gut-lung axis" have gradually raised attentions researchers. Several studies proved that short-chain fatty acids (SCFAs) produced microbiome play crucial roles varied activities process PALI. However, relevant reviews reporting SCFAs involvement lacking. In this review, we firstly introduced synthetic metabolic pathways SCFAs, transport signal transduction routes brief. Afterwards, focused on possible clues to participate fight against which referred inhibition pathogen proliferation, anti-inflammatory effects, enhancement barrier functions, maintenance regulation immune homeostasis via pathogen-associated patterns (PAMPs) damage-associated (DAMPs). addition, latest reported pathological physiological gut-lung axis involved were reviewed. Finally, summarized potential therapeutic interventions targeting including dietary fiber supplementation, direct supplementation SCFAs/prebiotics/probiotics, drugs administration, expected provide new sights for clinical use future.

Язык: Английский

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