Heliyon,
Год журнала:
2024,
Номер
10(10), С. e31514 - e31514
Опубликована: Май 1, 2024
The
gastrointestinal
tract
is
an
important
part
of
the
human
immune
system.
gut
microbiome,
which
constitutes
a
major
component
tract,
plays
crucial
role
in
maintaining
normal
physiological
functions
and
influences
development,
diagnosis,
immunotherapy
colorectal
cancer
(CRC).
Natural
polysaccharides
can
be
extracted
from
animals,
plants,
traditional
Chinese
medicines.
They
serve
as
essential
energy
source
for
promoting
probiotic
proliferation
regulating
intestinal
microecological
balance.
Moreover,
exhibit
anti-tumor
effects
due
to
their
regulatory
low
toxicity.
This
review
focuses
on
discussing
these
CRC,
along
with
improving
microbiome
dysbiosis
tumor
microenvironment,
providing
evidence
effective
therapeutic
strategies
against
CRC.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(21), С. 6578 - 6578
Опубликована: Ноя. 1, 2024
Colorectal
cancer
(CRC)
constitutes
a
significant
global
health
challenge,
with
recent
studies
underscoring
the
pivotal
role
of
gut
microbiome
in
its
pathogenesis
and
progression.
Fecal
microbiota
transplantation
(FMT)
has
emerged
as
compelling
therapeutic
approach,
offering
potential
to
modulate
microbial
composition
optimize
treatment
outcomes.
Research
suggests
that
specific
bacterial
strains
are
closely
linked
CRC,
influencing
both
clinical
management
interventions.
Moreover,
microbiome's
impact
on
immunotherapy
responsiveness
heralds
new
avenues
for
personalized
medicine.
Despite
promise
FMT,
safety
concerns,
particularly
immunocompromised
individuals,
remain
critical
issue.
Clinical
outcomes
vary
widely,
influenced
by
genetic
predispositions
methodologies
employed.
Additionally,
rigorous
donor
selection
screening
protocols
paramount
minimize
risks
maximize
efficacy.
The
current
body
literature
advocates
establishment
standardized
further
trials
substantiate
FMT's
CRC
management.
As
our
understanding
deepens,
FMT
is
poised
become
cornerstone
treatment,
imperative
continued
research
validation.
Journal of Biomedical Science,
Год журнала:
2025,
Номер
32(1)
Опубликована: Янв. 6, 2025
Abstract
Background
The
association
between
the
intestinal
microbiota
and
colorectal
cancer
(CRC)
has
been
extensively
studied,
with
Fusobacterium
nucleatum
(
F.
,
FN)
being
found
in
high
abundance
tissues.
Previous
research
emphasized
significant
role
of
occurrence
CRC.
However,
impact
on
CRC
liver
metastasis
not
well
understood.
Methods
effects
ability
cell
were
evaluated
vitro
examined
by
wound-healing
assay
transwell
assay.
mouse
model
was
constructed
spleen
injection,
degree
assessed
vivo
bioluminescence
imaging.
gene
expression
changes
cells
after
co-culture
analyzed
through
transcriptome
sequencing.
qRT-PCR
Western
Blot
assays
performed
to
validate
related
genes
proteins.
Results
significantly
enhanced
vitro.
In
model,
also
promoted
development
Mechanistically,
infection
increased
IL-8
downregulated
level
miR-5692a,
a
regulatory
microRNA
IL-8.
This
led
activation
ERK
pathway
resulted
epithelial-mesenchymal
transition
(EMT)
cells.
Conclusions
Our
results
suggest
that
promotes
inducing
miR-5692a/IL-8
axis.
These
findings
provide
new
insights
for
prevention
treatment
metastasis.
Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(4)
Опубликована: Май 14, 2024
Colorectal
cancer
(CRC)
is
a
common
digestive
tract
tumor,
with
incidences
continuing
to
rise.
Although
modern
medicine
has
extended
the
survival
time
of
CRC
patients,
its
adverse
effects
and
financial
burden
cannot
be
ignored.
multi-step
process
can
caused
by
disturbance
gut
microbiome
chronic
inflammation's
stimulation.
Additionally,
presence
precancerous
lesions
also
risk
factor
for
CRC.
Consequently,
scientists
are
increasingly
interested
in
identifying
multi-target,
safe,
economical
herbal
natural
products.
This
paper
summarizes
berberine's
(BBR)
regulatory
mechanisms
occurrence
development
The
findings
indicate
that
BBR
regulates
homeostasis
controls
mucosal
inflammation
prevent
In
stage,
inhibits
cell
proliferation,
invasion,
metastasis,
blocks
cycle,
induces
apoptosis,
metabolism,
angiogenesis,
enhances
chemosensitivity.
plays
role
overall
management
Therefore,
using
as
an
adjunct
prevention
treatment
could
become
future
trend
oncology.
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Dysbiosis
of
the
gut
microbiota
is
emerging
as
a
pivotal
factor
in
pathogenesis
colorectal
cancer
(CRC).
Ginsenoside
Rh4
(Rh4)
an
active
compound
isolated
from
ginseng
with
beneficial
effects
modulating
intestinal
inflammation
and
dysbiosis,
but
how
regulates
to
alleviate
CRC
remains
underexplored.
We
investigated
impact
on
mechanism
its
action
inhibiting
via
modulation
microbiota.
used
AOM/DSS
model
employed
transcriptomics,
genomics
metabolomics
techniques
explore
inhibitory
CRC.
Furthermore,
we
experiments
involving
antibiotic
treatment
fecal
transplantation
(FMT)
investigate
role
Finally,
elucidated
key
functional
bacteria
metabolites
regulated
by
Our
research
findings
indicated
that
repaired
barrier
damage
caused
CRC,
alleviated
inflammation,
inhibited
development
Additionally,
microbiota-dependent
manner.
increased
diversity
microbiota,
enriched
probiotic
Akkermansia
muciniphila
(A.
muciniphila),
dysbiosis
Subsequently,
A.
muciniphila-mediated
bile
acid
metabolism.
promoted
production
UDCA
enhancing
activity
7α-hydroxysteroid
dehydrogenase
(7α-HSDH).
further
activated
FXR,
modulated
TLR4-NF-κB
signaling
pathway,
thus
results
confirm
inhibits
manner
microbiota-mediated
metabolism
promoting
UDCA,
which
activates
FXR
receptor
pathway.
has
potential
be
modulator
for
preventing
Military Medical Research,
Год журнала:
2024,
Номер
11(1)
Опубликована: Июнь 3, 2024
Abstract
The
gut
microbiome
is
closely
associated
with
human
health
and
the
development
of
diseases.
Isolating,
characterizing,
identifying
microbes
are
crucial
for
research
on
essential
advancing
our
understanding
utilization
it.
Although
culture-independent
approaches
have
been
developed,
a
pure
culture
required
in-depth
analysis
disease
mechanisms
biotherapy
strategies.
Currently,
faces
challenge
expanding
existing
database
culturable
microbiota
rapidly
isolating
target
microorganisms.
This
review
examines
advancements
in
microbe
isolation
cultivation
techniques,
such
as
culturomics,
droplet
microfluidics,
phenotypic
genomics
selection,
membrane
diffusion.
Furthermore,
we
evaluate
progress
made
technology
considering
both
non-targeted
targeted
focus
future
microbial
culturomics
expected
to
be
high-throughput,
automation,
integration.
Advancements
this
field
may
facilitate
strain-level
investigation
into
underlying
diseases
related
microbiota.
Critical Reviews in Oncology/Hematology,
Год журнала:
2024,
Номер
203, С. 104480 - 104480
Опубликована: Авг. 22, 2024
Gastrointestinal
(GI)
cancer
continues
to
pose
a
significant
global
health
challenge.
Recent
advances
in
our
understanding
of
the
complex
relationship
between
host
and
gut
microbiota
have
shed
light
on
critical
role
metabolic
interactions
pathogenesis
progression
GI
cancer.
In
this
study,
we
examined
how
interact
with
influence
signalling
pathways
that
impact
formation
tumours.
Additionally,
investigated
potential
therapeutic
approach
manipulating
for
use
clinical
settings.
Revealing
molecular
exchanges
facilitates
deeper
underlying
mechanisms
drive
development.
Metabolic
hold
promise
identification
microbial
signatures
or
associated
specific
stages
Hence,
study
provides
strategies
diagnosis,
treatment
management
cancers
improve
patient
outcomes.
