Translational study of the regulatory mechanism by which immune synapses enhance immune cell function
Cancer Letters,
Год журнала:
2025,
Номер
614, С. 217542 - 217542
Опубликована: Фев. 7, 2025
Язык: Английский
Theoretical Framework and Emerging Challenges of Lipid Metabolism in Cancer
Seminars in Cancer Biology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Elevated
lipid
metabolism
is
one
of
hallmarks
malignant
tumors.
Lipids
not
only
serve
as
essential
structural
components
biological
membranes
but
also
provide
energy
and
substrates
for
the
proliferation
cancer
cells
tumor
growth.
Cancer
meet
their
needs
by
coordinating
processes
absorption,
synthesis,
transport,
storage,
catabolism.
As
research
in
this
area
continues
to
deepen,
numerous
new
discoveries
have
emerged,
making
it
crucial
scientists
stay
informed
about
developments
metabolism.
In
review,
we
first
discuss
relevant
concepts
theories
or
assumptions
that
help
us
understand
-based
therapies.
We
then
systematically
summarize
latest
advancements
including
mechanisms,
novel
targets,
up-to-date
pre-clinical
clinical
investigations
anti-cancer
treatment
with
targeted
drugs.
Finally,
emphasize
emerging
directions
therapeutic
strategies,
future
prospective
challenges.
This
review
aims
insights
guidance
field
Язык: Английский
·Role of Cathepsin K in Bone Invasion of Pituitary Adenomas: A Dual Mechanism Involving Cell Proliferation and Osteoclastogenesis
Cancer Letters,
Год журнала:
2025,
Номер
611, С. 217443 - 217443
Опубликована: Янв. 5, 2025
Язык: Английский
Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy
Cell Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
GLP1 alleviates oleic acid-propelled lipocalin-2 generation by tumor-infiltrating CD8+ T cells to reduce polymorphonuclear MDSC recruitment and enhances viral immunotherapy in pancreatic cancer
Cellular and Molecular Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Язык: Английский
Regulation of immune metabolism in Th17 and Treg cells
Animals and zoonoses.,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Microbiome, Metabolome, and Ionome Profiling of Cystic Fluids Reveals Heterogeneity in Pancreatic Cystic Neoplasms
Cancer Letters,
Год журнала:
2025,
Номер
623, С. 217730 - 217730
Опубликована: Апрель 18, 2025
Язык: Английский
Cabozantinib Enhances CAIX Specific CAR-T cells Against Renal Cancer by Augmenting Tumor Immune Microenvironment
Biochemical and Biophysical Research Communications,
Год журнала:
2024,
Номер
734, С. 150781 - 150781
Опубликована: Окт. 1, 2024
Язык: Английский
Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8+ T cells for triple-negative breast cancer therapy
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
unknown, С. 100970 - 100970
Опубликована: Окт. 1, 2024
Ferroptosis
can
serve
as
a
potent
strategy
for
regulating
cell
death
via
lipid
peroxidation
and
the
imbalance
of
antioxidant
system
resulting
from
iron
accumulation
in
triple-negative
breast
cancer
(TNBC)
therapy.
However,
ferroptosis
accompanied
with
down-regulation
glutathione
peroxidase
4
(GPX4)
lead
to
CD36-mediated
tumor-infiltrating
CD8+
T
cells
uptaking
fatty
acids,
negative
action
on
immunotherapeutic
efficacy.
Herein,
albumin
nanoparticles,
abbreviated
LHS
NPs,
were
designed
by
co-assembly
hemin,
linoleic
acid-cystamine,
CD36
inhibitor
sulfosuccinimide
oleate,
bi-directionally
manipulated
tumor
TNBC
NPs
exerted
more
efficient
reactive
oxygen
species
generation,
depletion
malondialdehyde
production
combinatory
classical
non-classical
modes,
which
amplified
positive
cells.
Meanwhile,
inhibiting
mediated-lipid
cells,
thereby
activating
efficacy
improvements
induction
immunogenic
death,
proliferation
CD4+CD8+
natural
killer
alleviation
immunosuppressive
regulatory
myeloid-derived
suppressor
repolarization
M2-
M1-phenotype
tumor-associated
macrophages.
Thus,
demonstrated
an
improved
antitumor
suppressing
growth
lung
metastasis
4T1-tumor
mice.
Our
work
gives
novel
insights
manipulating
chemoimmunotherapy.
Язык: Английский