Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8+ T cells for triple-negative breast cancer therapy DOI Creative Commons
Ting Yang, Zihan Liu,

Zixuan Fu

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 100970 - 100970

Published: Oct. 1, 2024

Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of antioxidant system resulting from iron accumulation in triple-negative breast cancer (TNBC) therapy. However, ferroptosis accompanied with down-regulation glutathione peroxidase 4 (GPX4) lead to CD36-mediated tumor-infiltrating CD8+ T cells uptaking fatty acids, negative action on immunotherapeutic efficacy. Herein, albumin nanoparticles, abbreviated LHS NPs, were designed by co-assembly hemin, linoleic acid-cystamine, CD36 inhibitor sulfosuccinimide oleate, bi-directionally manipulated tumor TNBC NPs exerted more efficient reactive oxygen species generation, depletion malondialdehyde production combinatory classical non-classical modes, which amplified positive cells. Meanwhile, inhibiting mediated-lipid cells, thereby activating efficacy improvements induction immunogenic death, proliferation CD4+CD8+ natural killer alleviation immunosuppressive regulatory myeloid-derived suppressor repolarization M2- M1-phenotype tumor-associated macrophages. Thus, demonstrated an improved antitumor suppressing growth lung metastasis 4T1-tumor mice. Our work gives novel insights manipulating chemoimmunotherapy.

Language: Английский

Translational study of the regulatory mechanism by which immune synapses enhance immune cell function DOI

Yahui Li,

Xiao‐Jun Huang, Xiang‐Yu Zhao

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 614, P. 217542 - 217542

Published: Feb. 7, 2025

Language: Английский

Citations

1
Theoretical Framework and Emerging Challenges of Lipid Metabolism in Cancer DOI Creative Commons
Qiuying Gu, Yuan Wang, Ping Yi

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Elevated lipid metabolism is one of hallmarks malignant tumors. Lipids not only serve as essential structural components biological membranes but also provide energy and substrates for the proliferation cancer cells tumor growth. Cancer meet their needs by coordinating processes absorption, synthesis, transport, storage, catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial scientists stay informed about developments metabolism. In review, we first discuss relevant concepts theories or assumptions that help us understand -based therapies. We then systematically summarize latest advancements including mechanisms, novel targets, up-to-date pre-clinical clinical investigations anti-cancer treatment with targeted drugs. Finally, emphasize emerging directions therapeutic strategies, future prospective challenges. This review aims insights guidance field

Language: Английский

Citations

6
·Role of Cathepsin K in Bone Invasion of Pituitary Adenomas: A Dual Mechanism Involving Cell Proliferation and Osteoclastogenesis DOI

Hongyan Liu,

Peng Wang, Jiakui Li

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 611, P. 217443 - 217443

Published: Jan. 5, 2025

Language: Английский

Citations

0
Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy DOI
Andrew Frisch, Yiyang Wang, Bingxian Xie

et al.

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
GLP1 alleviates oleic acid-propelled lipocalin-2 generation by tumor-infiltrating CD8+ T cells to reduce polymorphonuclear MDSC recruitment and enhances viral immunotherapy in pancreatic cancer DOI
Jingyi Wu, Qian Peng, Yifeng Han

et al.

Cellular and Molecular Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

0
Regulation of immune metabolism in Th17 and Treg cells DOI Creative Commons

Zhanqing Ji,

Wei Yang, Siyao Li

et al.

Animals and zoonoses., Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Microbiome, Metabolome, and Ionome Profiling of Cystic Fluids Reveals Heterogeneity in Pancreatic Cystic Neoplasms DOI
Sen Yang, Ya Hu, Ming Cui

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 623, P. 217730 - 217730

Published: April 18, 2025

Language: Английский

Citations

0
Cabozantinib Enhances CAIX Specific CAR-T cells Against Renal Cancer by Augmenting Tumor Immune Microenvironment DOI
Qihong Li, Lin Yang, Shuyu Li

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 734, P. 150781 - 150781

Published: Oct. 1, 2024

Language: Английский

Citations

0
Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8+ T cells for triple-negative breast cancer therapy DOI Creative Commons
Ting Yang, Zihan Liu,

Zixuan Fu

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 100970 - 100970

Published: Oct. 1, 2024

Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of antioxidant system resulting from iron accumulation in triple-negative breast cancer (TNBC) therapy. However, ferroptosis accompanied with down-regulation glutathione peroxidase 4 (GPX4) lead to CD36-mediated tumor-infiltrating CD8+ T cells uptaking fatty acids, negative action on immunotherapeutic efficacy. Herein, albumin nanoparticles, abbreviated LHS NPs, were designed by co-assembly hemin, linoleic acid-cystamine, CD36 inhibitor sulfosuccinimide oleate, bi-directionally manipulated tumor TNBC NPs exerted more efficient reactive oxygen species generation, depletion malondialdehyde production combinatory classical non-classical modes, which amplified positive cells. Meanwhile, inhibiting mediated-lipid cells, thereby activating efficacy improvements induction immunogenic death, proliferation CD4+CD8+ natural killer alleviation immunosuppressive regulatory myeloid-derived suppressor repolarization M2- M1-phenotype tumor-associated macrophages. Thus, demonstrated an improved antitumor suppressing growth lung metastasis 4T1-tumor mice. Our work gives novel insights manipulating chemoimmunotherapy.

Language: Английский

Citations

0