The opportunities and challenges of using PD-1/PD-L1 inhibitors for leukemia treatment

Cancer Letters, Год журнала: 2024, Номер 593, С. 216969 - 216969

Опубликована: Май 19, 2024

Язык: Английский

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Investigating autophagy and intricate cellular mechanisms in hepatocellular carcinoma: Emphasis on cell death mechanism crosstalk

Cancer Letters, Год журнала: 2024, Номер 588, С. 216744 - 216744

Опубликована: Март 1, 2024

Hepatocellular carcinoma (HCC) stands as a formidable global health challenge due to its prevalence, marked by high mortality and morbidity rates. This cancer type exhibits multifaceted etiology, prominently linked viral infections, non-alcoholic fatty liver disease, genomic mutations. The inherent heterogeneity of HCC, coupled with proclivity for developing drug resistance, presents obstacles effective therapeutic interventions. Autophagy, fundamental catabolic process, plays pivotal role in maintaining cellular homeostasis, responding stressors such nutrient deprivation. In the context tumor cells exploit autophagy, either augmenting or impeding activity, thereby influencing tumorigenesis. comprehensive review underscores dualistic autophagy acting both pro-survival pro-death mechanism, impacting trajectory anti-carcinogenic potential is evident ability enhance apoptosis ferroptosis HCC cells. Pertinently, dysregulated fosters resistance carcinogenic context. Both epigenetic factors can regulate progression. Recognizing paramount importance progression, this introduces pharmacological compounds capable modulating autophagy—either inducing inhibiting it, promising avenues therapy.

Язык: Английский

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·Role of Cathepsin K in Bone Invasion of Pituitary Adenomas: A Dual Mechanism Involving Cell Proliferation and Osteoclastogenesis

Cancer Letters, Год журнала: 2025, Номер 611, С. 217443 - 217443

Опубликована: Янв. 5, 2025

Язык: Английский

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EBF1-induced CSRP2 boosts the progression of B-cell acute lymphocytic leukemia by inhibiting ferroptosis

Cancer Letters, Год журнала: 2025, Номер 614, С. 217556 - 217556

Опубликована: Фев. 12, 2025

Язык: Английский

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Hedgehog and PI3K/Akt/mTOR Signaling Pathways Involvement in Leukemic Malignancies: Crosstalk and Role in Cell Death

Cells, Год журнала: 2025, Номер 14(4), С. 269 - 269

Опубликована: Фев. 13, 2025

The Hedgehog (Hh) and PI3K/Akt/mTOR signaling pathways play a pivotal role in driving the initiation progression of various cancers, including hematologic malignancies such as acute lymphoblastic leukemia (ALL), myeloid (AML), chronic (CML), lymphocytic (CLL). These are often dysregulated cells, leading to increased cell growth, survival, drug resistance while also impairing mechanisms death. In leukemia, Hh pathway can be abnormally activated by genetic mutations. Additionally, is frequently overactive due changes. A key aspect these their interaction: activation PI3K/Akt trigger non-canonical pathway, which further promotes growth survival. Targeted inhibitors pathways, Gli PI3K/mTOR inhibitors, have shown promise preclinical clinical studies.

Язык: Английский

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The expression level of EVI1 and clinical features help to distinguish prognostic heterogeneity in the AML entity with EVI1 overexpression

Cancer Letters, Год журнала: 2025, Номер 615, С. 217547 - 217547

Опубликована: Фев. 14, 2025

Язык: Английский

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Interplay between LncRNAs and autophagy-related pathways in leukemia: mechanisms and clinical implications

Medical Oncology, Год журнала: 2025, Номер 42(5)

Опубликована: Апрель 9, 2025

Язык: Английский

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Activation of autophagy, paraptosis, and ferroptosis by micheliolide through modulation of the MAPK signaling pathway in pancreatic and colon tumor cells

Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155654 - 155654

Опубликована: Окт. 11, 2024

Язык: Английский

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