International Journal of Biological Macromolecules, Год журнала: 2024, Номер 291, С. 139147 - 139147
Опубликована: Дек. 23, 2024
Язык: Английский
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Авг. 26, 2024
Abstract CAFs (cancer-associated fibroblasts) are highly flexible cells of the cancer microenvironment. They produce extracellular matrix (ECM) constituents that form structure tumor stroma but also a source metabolites, growth factors, chemokines, and exosomes impact every aspect tumor, including its response to treatment. It is believed exosomal miRNAs facilitate intercellular signaling, which essential for development cancer. The role in microenvironment (TME) carcinogenesis reviewed this paper. preferred reporting items systematic reviews meta-analyses (PRISMA) 2020 guidelines were used perform review. Several databases, Web Science, Medline, Embase, Cochrane Library, Scopus, searched using following keywords: CAFs, CAF, cancer-associated fibroblasts, stromal miRNA, miRNAs, exosome similar terms. We identified studies investigating TME their carcinogenesis. A total 12,572 papers identified. After removing duplicates ( n = 3803), 8774 articles screened by title abstract. Of these, 421 excluded from further analysis. has been reported if not functioning correctly, may influence secretory phenotype tip contribute increased invasiveness, spread, decreased treatment efficacy, poorer prognosis. Under influence, normal fibroblasts (NFs) transformed into CAFs. Furthermore, they participate metabolic reprogramming, allows fast proliferation cell population, adaptation growing energy demands, capacity avoid immune system identification.
Язык: Английский
Процитировано
12
Theranostics, Год журнала: 2025, Номер 15(5), С. 1966 - 1986
Опубликована: Янв. 6, 2025
Background: Identifying biomarkers that predict immunotherapy efficacy and discovering new targets for combination therapies are critical elements improving the prognosis of bladder cancer (BLCA) patients. Methods: Firstly, we explored expression patterns TBX3 in normal pan-cancer tissues correlation between immune microenvironment using data from multiple public databases. Then, combined various techniques, including bulk RNA sequencing, single-cell high-throughput cytokine arrays, functional experiments, ProcartaPlex multiplex immunoassays TissueFAXS panoramic tissue quantification assays, to demonstrate shapes an immunosuppressive tumor (TME) BLCA. Results: We identified as a key factor associated with BLCA through systematic multi-omics analysis. found is primarily expressed malignant cells, where TBX3high cells increase secretion TGFβ1, which promotes infiltration cancer-associated fibroblasts (CAFs), thereby forming microenvironment. further demonstrated enhances TGFβ1 by binding promoter, blocking counteracts effects TBX3. Moreover, reduced cancer-killing efficiency CD8+ T decreasing proportion GZMB+ knocking down anti-PD-1 treatment increased cell CAFs vivo. also validated inverse relationship TBX3+ positive microarrays. Lastly, predicted our real-world cohort cohorts. Conclusion: In summary, progression resistance inducing microenvironment, targeting could enhance
Язык: Английский
Процитировано
0
International Journal of Surgery, Год журнала: 2025, Номер 111(3), С. 2590 - 2602
Опубликована: Янв. 7, 2025
The immune response is modulated by a diverse array of signals within the tissue microenvironment, encompassing biochemical factors, mechanical forces, and pressures from adjacent tissues. Furthermore, extracellular matrix its constituents significantly influence function cells. In case carcinogenesis, changes in biophysical properties tissues can impact received cells, these c1an be translated into through mechano-transduction pathways. These pathways have profound on cellular functions, influencing processes such as cell activation, metabolism, proliferation, migration, etc. Tissue mechanics may undergo temporal during process offering potential for novel dynamic levels regulation. Here, we review advances mechanoimmunology malignancy studies, focusing how mechanosignals modulate behaviors cells at level, thereby triggering an that ultimately influences development progression malignant tumors. Additionally, also focused mechano-immunoengineering systems, with help which could to further understand tumor or alterations microenvironment provide new research directions overcoming immunotherapeutic resistance
Язык: Английский
Процитировано
0
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189274 - 189274
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2025, Номер 614, С. 217556 - 217556
Опубликована: Фев. 12, 2025
Язык: Английский
Процитировано
0
Pathology - Research and Practice, Год журнала: 2025, Номер 269, С. 155864 - 155864
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 10, 2025
Phosphodiesterase 4 (PDE4) is an enzyme that specifically hydrolyzes the second messenger cAMP and has a critical role in regulation of variety cellular functions. In recent years, PDE4 attracted great interest cancer research, its tumorigenesis development been gradually elucidated. Research indicates abnormal expression or heightened activity associated with initiation progression multiple cancers, including lung, colorectal, hematological by facilitating cell proliferation, migration, invasion, anti-apoptosis. Moreover, also influences tumor immune microenvironment, significantly evasion suppressing anti-tumor responses, reducing T-cell activation, promoting polarization tumor-associated macrophages toward pro-tumorigenic phenotype. However, family may have both oncogenic tumor-suppressive effects, which could depend on specific type grade tumor. inhibitors garnered substantial as potential anti-cancer therapeutics, directly inhibiting growth restoring surveillance capabilities to enhance clearance cells. Several are currently under investigation aim exploring their therapy, particularly combination strategies checkpoint inhibitors, improve therapeutic efficacy mitigate side effects conventional chemotherapy. This review provides overview tumorigenesis, drug resistance, immunotherapy, actions intending guide exploration new target therapy.
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217594 - 217594
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
International Journal of Oncology, Год журнала: 2024, Номер 65(5)
Опубликована: Сен. 25, 2024
Acute myeloid leukemia (AML) is a hematological malignancy with high relapse rate and poor survival rate. The circular RNA circPVT1 myocyte enhancer factor 2A (MEF2A) have unique functions in the progression of AML; however, underlying mechanisms clinical significance remain to be clarified. Bioinformatics database analyses were used assess transcription factors target genes circPVT1. Dual‑luciferase reporter gene argonaute 2‑RNA immunoprecipitation assays verify targeted relationships. expression levels related proteins detected by reverse transcription‑quantitative PCR western blotting. Cell viability apoptosis Counting Kit‑8 assay flow cytometry, respectively. results revealed that was highly expressed AML samples cell lines, MEF2A regulated overexpression promoted epithelial‑mesenchymal transition (EMT), inhibited apoptosis. In addition, regulation microRNA (miR)‑455‑3p, miR‑455‑3p MCL1 expression, thus indicating through its interaction miR‑455‑3p. Furthermore, cells transfected small interfering RNA‑(si)‑circPVT1, inhibitor or si‑MCL1, si‑circPVT1 si‑MCL1 EMT NB4 HL‑60 cells. However, had opposite effect on conclusion, may act as promote malignant process AML, knockdown could inhibit miR‑455‑3p/MCL1 axis.
Язык: Английский
Процитировано
2
Cancer Letters, Год журнала: 2024, Номер 598, С. 217099 - 217099
Опубликована: Июль 4, 2024
An optimum safety excision margin (EM) delineated by precise demarcation of field cancerization along with reliable biomarkers that enable predicting and timely evaluating patients' response to immunotherapy significantly impact effective management melanoma. In this study, optimized biphasic "immunofluorescence staining integrated fluorescence insitu hybridization" (iFISH) was conducted the diagnosis-metastasis-treatment-cellular MRD axis longitudinally co-detect a full spectrum intact CD31
Язык: Английский
Процитировано
0