Exploring the molecular interface of gene expression dynamics and prostate cancer susceptibility in response to HBCD exposure DOI
Ying Ni, Wenkai Wang, Lihua Jiang

и другие.

Toxicology Research, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 31, 2024

Abstract Hexabromocyclododecane (HBCD), a brominated flame retardant, is linked to various health implications, including prostate cancer. This study explored the molecular mechanisms and potential biomarkers associated with HBCD exposure using data from Comparative Toxicogenomics Database (CTD) The Cancer Genome Atlas (TCGA). A total of 7,147 differentially expressed genes (DEGs) 46 miRNAs were identified, significant enrichment in cancer-related pathways xenobiotic metabolism. Protein–protein interaction (PPI) network construction analyses revealed four hub genes: DNAJC12, PKMYT1, RRM2, SLC12A5. These displayed notable expression changes response strongly correlated survival outcomes cancer patients, as demonstrated by Cox regression ROC curve analyses. Additionally, miRNA correlation indicated robust positive associations, highlighting coordinated regulatory network. Experimental on HBCD-treated cell lines further validated these findings. sheds light impact gene cancer, emphasizing identified prognostic therapeutic targets. By elucidating networks influenced HBCD, findings provide foundation for developing strategies mitigate its carcinogenic effects improve patients.

Язык: Английский

Molecular insights to therapeutic in cancer: role of exosomes in tumor microenvironment, metastatic progression and drug resistance DOI

Shikshya S. Panda,

Rajeev Kumar Sahoo,

Sambit K. Patra

и другие.

Drug Discovery Today, Год журнала: 2024, Номер 29(8), С. 104061 - 104061

Опубликована: Июнь 18, 2024

Язык: Английский

Процитировано

6
Targeting STAT3 potentiates CDK4/6 inhibitors therapy in head and neck squamous cell carcinoma DOI
Lin Dong,

Chao Liu,

Haoyang Sun

и другие.

Cancer Letters, Год журнала: 2024, Номер 593, С. 216956 - 216956

Опубликована: Май 11, 2024

Язык: Английский

Процитировано

4
Cancer-associated fibroblasts in breast cancer in the single-cell era: Opportunities and challenges DOI

Jingtong Yang,

Benkai Xin,

Xiaoyu Wang

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189291 - 189291

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
MicroRNAs and lysosomal membrane proteins: Critical interactions in tumor progression and therapy DOI
Jiahao Xu, Shiqiang Liu, Yujie Jin

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189303 - 189303

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Non-Coding RNAs: Key Regulators of CDK and Wnt/β-catenin signaling in Cancer DOI
Mohammad Arshad Javed Shaikh, M. Arockia Babu, Nehmat Ghaboura

и другие.

Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155659 - 155659

Опубликована: Окт. 16, 2024

Язык: Английский

Процитировано

1
TFAP2C-DDR1 Axis Regulates Resistance to CDK4/6 Inhibitor in Breast Cancer DOI
Muhammad Jameel, Yi Zhang, Zhuqing Li

и другие.

Cancer Letters, Год журнала: 2024, Номер unknown, С. 217356 - 217356

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0
Exploring the molecular interface of gene expression dynamics and prostate cancer susceptibility in response to HBCD exposure DOI
Ying Ni, Wenkai Wang, Lihua Jiang

и другие.

Toxicology Research, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 31, 2024

Abstract Hexabromocyclododecane (HBCD), a brominated flame retardant, is linked to various health implications, including prostate cancer. This study explored the molecular mechanisms and potential biomarkers associated with HBCD exposure using data from Comparative Toxicogenomics Database (CTD) The Cancer Genome Atlas (TCGA). A total of 7,147 differentially expressed genes (DEGs) 46 miRNAs were identified, significant enrichment in cancer-related pathways xenobiotic metabolism. Protein–protein interaction (PPI) network construction analyses revealed four hub genes: DNAJC12, PKMYT1, RRM2, SLC12A5. These displayed notable expression changes response strongly correlated survival outcomes cancer patients, as demonstrated by Cox regression ROC curve analyses. Additionally, miRNA correlation indicated robust positive associations, highlighting coordinated regulatory network. Experimental on HBCD-treated cell lines further validated these findings. sheds light impact gene cancer, emphasizing identified prognostic therapeutic targets. By elucidating networks influenced HBCD, findings provide foundation for developing strategies mitigate its carcinogenic effects improve patients.

Язык: Английский

Процитировано

0