SAGE Open Medicine, Год журнала: 2024, Номер 12
Опубликована: Янв. 1, 2024
Nonsmall cell lung cancer is a leading cause of cancer-related death worldwide. The long noncoding RNA MIR4435-2HG has been shown to play carcinogenic role in various cancers. purpose this study was explore the and regulatory mechanism non-small cancer.
Язык: Английский
ONCOLOGIE, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
The NatA complex is composed of the NAA10, NAA15, and HYPK subunits. It primarily responsible for N-terminal acetylation, a critical post-translational modification in eukaryotes. Pathogenic variants within NAA10 cause Ogden Syndrome (OS), which characterized by varying degrees intellectual disability, hypotonia, developmental delay, cardiac abnormalities. Although manifestations disease have been described extensively case reports, there has not study focusing on their recommended clinical management. In this study, we describe OS cohort 85 probands. We found increased incidence structural electrophysiologic abnormalities, with particularly high prevalence QT interval prolongation. Sub-analysis showed that male probands those NAA15-binding domain had more severe phenotypes than females or outside domain. Our results suggest an diagnosis should be accompanied full workup emphasis echocardiogram defects EKG/Holter monitoring Additionally, strongly recommend use QT-prolonging drugs followed up routine electrophysiological consultation pediatric cardiologist. hope guides clinicians caregivers treating patients moves field toward standardized diagnostic condition.
Язык: Английский
Процитировано
1
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 29, 2025
Abstract Lung carcinoma incidence and fatality rates remain among the highest on a global scale. The efficacy of targeted therapies immunotherapies is commonly compromised by emergence drug resistance other factors, resulting in lack durable therapeutic benefits. Ferroptosis, distinct pattern cell death marked buildup iron-dependent lipid peroxides, has been shown to be novel potentially more effective treatment for lung carcinoma. However, mechanism regulatory network ferroptosis are exceptionally complex, many unanswered questions remain. In addition, research diagnosis cancer growing exponentially. Therefore, it necessary provide thorough summary latest advancements field ferroptosis. Here, we comprehensively analyze mechanisms underlying preconditions ferroptosis, defense system, associated molecular networks. potential strategies also highlighted. Targeting improves tumor enhances effectiveness drugs immunotherapies. These findings may shed fresh light management carcinoma, as well development related
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217503 - 217503
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2025, Номер 6(3)
Опубликована: Фев. 23, 2025
Ferroptosis is a distinct form of iron-dependent programmed cell death characterized primarily by intracellular iron accumulation and lipid peroxidation. Multiple cellular processes, including amino acid metabolism, various signaling pathways, autophagy, have been demonstrated to influence the induction progression ferroptosis. Recent investigations elucidated that ferroptosis plays crucial role in pathogenesis pulmonary disorders, lung injury, chronic obstructive disease, fibrosis, asthma. increasingly recognized as promising novel strategy for cancer treatment. Various immune cells within tumor microenvironment, CD8+ T cells, macrophages, regulatory natural killer dendritic shown induce modulate process through regulation metabolism pathways. Conversely, can reciprocally alter metabolic environment, leading activation or inhibition functions, thereby modulating responses. This paper reviews molecular mechanism describes discusses connection between microenvironment diseases, development prospect their interaction treatment diseases.
Язык: Английский
Процитировано
0
Cancer Medicine, Год журнала: 2025, Номер 14(5)
Опубликована: Март 1, 2025
Arrest-deficient protein 1 (ARD1) is an acetyltransferase that acetylates the N-terminal amino acids and internal lysine residues of proteins. It plays a crucial role in various cellular processes. The significance ARD1 tumor development has become increasingly evident recent years. This review analyzes regulatory progression by examining its involvement processes such as cell cycle regulation, proliferation, metastasis, apoptosis, autophagy. Additionally, we discuss expression patterns molecular mechanisms different types cancer. Elevated levels have been reported several cancer types. Its increased associated with characteristics, suggesting it may serve potential prognostic biomarker. Furthermore, could be targeted for novel therapies. Understanding biology provides valuable insights into therapeutic targets biomarkers treatment. highlights advances ARD1-related research suggests promising avenue improving prognosis treatment strategies.
Язык: Английский
Процитировано
0
Bioengineering & Translational Medicine, Год журнала: 2025, Номер unknown
Опубликована: Апрель 16, 2025
Abstract Non‐small cell lung cancer (NSCLC) presents significant therapeutic challenges, often characterized by aggressive proliferation and metastasis. This study investigates the role of SLC7A11, a ferroptosis‐related gene, in NSCLC progression potential engineered bacterial extracellular vesicles (BEVs) expressing SLC7A11‐targeting siRNA as strategy. Using TCGA GEO databases, we identified that SLC7A11 was significantly upregulated tissues. Functional assays demonstrated knockdown lines (NCI‐H2122 NCI‐H647) via qPCR, Western blot, immunofluorescence resulted impaired proliferation, migration, invasion abilities. In vivo xenograft models further revealed inhibited tumor growth metastasis, corroborated histological analyses. To enhance targeted delivery siRNA, BEVs with targeting peptide, verifying their structure function through transmission electron microscopy (TEM) nanoparticle tracking analysis (NTA). toxicity assessments indicated safety for these bioengineered vesicles. Importantly, treatment BEVs‐LCTP‐siSLC7A11 not only tumorigenesis but also activated ferroptosis pathways, evidenced altered expression levels transferrin metastatic Our findings suggest promising approach to inhibit while activating ferroptosis, offering insights into novel strategies against cancer.
Язык: Английский
Процитировано
0
Bioengineering, Год журнала: 2024, Номер 11(9), С. 893 - 893
Опубликована: Сен. 5, 2024
Anoikis is a distinct type of programmed cell death and unique mechanism for tumor progress. However, its exact function in gastric cancer (GC) remains unknown. This study aims to investigate the anoikis-related lncRNA (ar-lncRNA) prognosis GC immunological infiltration. The ar-lncRNAs were derived from RNA sequencing data associated clinical information obtained Cancer Genome Atlas. Pearson correlation analysis, differential screening, LASSO Cox regression utilized identify typical with prognostic significance, corresponding risk model was constructed, respectively. Comprehensive methods employed assess characteristics prediction model, ensuring accuracy results. Further analysis conducted on relationship between immune microenvironment features, sensitivity predictions made about anticancer medicines. A built according seven selected ar-lncRNAs. validated calibration plots highly consistent validating nomogram predictions. analyses revealed great ability serve as stand-alone factor. We subsequently disclosed that high-risk groups display significant enrichment pathways related tumors system. Additionally, immunoassays, notable variations infiltrates checkpoints noted different groups. proposes, first time, signatures ar-lncRNA can be established GC. These accurately predict offer potential biomarkers, suggesting new avenues basic research, personalized diagnosis treatment
Язык: Английский
Процитировано
2
Journal of Thoracic Disease, Год журнала: 2024, Номер 16(12), С. 8754 - 8770
Опубликована: Дек. 1, 2024
Tyrosine kinase inhibitors (TKIs) are the first-line therapy for patients with non-small cell lung cancer (NSCLC) sensitized mutations in epidermal growth factor receptor (EGFR). However, resistance to TKIs is a major clinical issue that affects survival and prognosis of patients, mechanisms underlying this remaining elusive. Circular RNAs (circRNAs) class single-stranded, covalently closed RNA molecules, which generated from pre-messenger (mRNAs) through back splicing. The aim study was investigate role cRNA SPECC1 promoting NSCLC explore its potential involvement tumorigenesis metastasis adenocarcinoma (LUAD). In study, we identified differentially expressed genes sequencing three tumor samples obtained poor postoperative TKI treatment outcomes. Validation performed using quantitative real-time polymerase chain reaction (qRT-PCR) function experiments. We further constructed competing endogenous (ceRNA) network Gene Ontology (GO) analysis circRNA. circular (circSPECC1) found be significantly upregulated tumors as compared adjacent tissues. Knockdown circSPECC1 lines resulted decreased proliferation, migration, invasion. Additionally, apoptosis increased TKI-sensitive EGFR when treated osimertinib. may promote contribute NSCLC. This offers novel perspective on research at level.
Язык: Английский
Процитировано
1
Cellular Signalling, Год журнала: 2024, Номер 124, С. 111439 - 111439
Опубликована: Сен. 27, 2024
Язык: Английский
Процитировано
0