Pan-cancer analysis reveals MTTP as a prognostic and immunotherapeutic biomarker in human tumors DOI Creative Commons
Wenjia Wang, Yaping Gao, Yihan Liu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 27, 2025

Introduction Microsomal triglyceride transfer protein (MTTP) is an essential lipid for the synthesis and secretion of very low density lipoprotein (VLDL) in hepatocytes chylomicrons (CM) intestinal cells. Further researches have revealed that MTTP exerted its functions a variety tissues beyond liver intestine, including heart, neural antigen-presenting Dysregulation expression can lead to many diseases, such as metabolism disorders, insulin resistance cardiovascular diseases. Despite importance, research on cancer limited, with no comprehensive pan-cancer studies available. Methods was explored TIMER 2.0 Sangerbox databases. The pathological stages survival analysis were analyzed via GEPIA Kaplan Meier plotter. gene mutations by cBioPortal database. immune landscape tumor microenvironment(TME) using single-cell sequencing. Based RNA-seq data TCGA, we constructed GSEA enrichment MTTP. We identified pro-tumor anti-ferroptosis gastric (GC) cells vitro vivo experiments, effect TME ferroptosis Results elevated at least 1/3 tumors. High associated poor prognosis most levels significantly correlated three scores (immune, stromal, extimate) checkpoints half types. Single cell sequencing showed mainly expressed macrophages, especially microglia. increased GC knockdown limited proliferation, migration invasion abilities cells, accompanied sensitivity ferroptosis. In addition, analyzing genes single level, found macrophages may be involved process GC. Conclusions Our study emphasizes promising prognostic immunotherapeutic biomarker infiltration diverse regulates providing potential target immunotherapy.

Язык: Английский

AXL: shapers of tumor progression and immunosuppressive microenvironments DOI Creative Commons
Yihui Liu, Lei Xu, Yuanyao Dou

и другие.

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 11, 2025

As research progresses, our understanding of the tumor microenvironment (TME) has undergone profound changes. The TME evolves with developmental stages cancer and implementation therapeutic interventions, transitioning from an immune-promoting to immunosuppressive microenvironment. Consequently, we focus intently on significant role in proliferation, metastasis, development drug resistance. AXL is highly associated progression; however, previous studies have been limited its impact biological behavior cells. An increasing body now demonstrates that can influence function differentiation immune cells, mediating suppression thereby fostering growth. A comprehensive analysis identify overcome causes microenvironments represents a novel approach conquering cancer. In this review, elucidating within microenvironments, discussing analyzing effects T macrophages, natural killer (NK) fibroblasts, other immune-stromal We aim clarify contributions progression resistance functional

Язык: Английский

Процитировано

2
Recent Treatment Strategies and Molecular Pathways in Resistance Mechanisms of Antiangiogenic Therapies in Glioblastoma DOI Open Access
Md. Ataur Rahman,

Meser M. Ali

Cancers, Год журнала: 2024, Номер 16(17), С. 2975 - 2975

Опубликована: Авг. 27, 2024

Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.

Язык: Английский

Процитировано

9
Hepatic stellate cells promote hepatocellular carcinoma development by regulating histone lactylation: novel insights from single-cell RNA sequencing and spatial transcriptomics analyses DOI

Yifan Yu,

Yongnan Li, Long Zhou

и другие.

Cancer Letters, Год журнала: 2024, Номер unknown, С. 217243 - 217243

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

9
Targeted delivery and controlled release of polymeric nanomedicines for tumor therapy DOI Creative Commons
Na Shen, Weidong Zhao,

Hongyu Chu

и другие.

Fundamental Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Ursodeoxycholic Acid Platinum(IV) Conjugates as Antiproliferative and Antimetastatic Agents: Remodel the Tumor Microenvironment through Suppressing JAK2/STAT3 Signaling DOI
Yan Chen, Ming Zhang, Zhifang Liu

и другие.

Journal of Medicinal Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Tumor microenvironment (TME) is a pivotal factor driving the tumor metastasis and leading to failure of therapy. Here, series ursodeoxycholic acid platinum(IV) conjugates with potency in remodeling TME through suppressing JAK2/STAT3 signaling was developed. A candidate screened out, which displayed potent antiproliferative antimetastatic performance both

Язык: Английский

Процитировано

5
Multi-omics analysis identifies DLX4 as a novel biomarker for diagnosis, prognosis, and immune infiltration: from pan-cancer to renal cancer DOI Creative Commons

Zengshun Kou,

Shuaizhi Zhu,

Jiaxi Zhu

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 5, 2025

DLX4 is involved in the regulation of embryonic development, but its function cancer remains unclear. Here, we conducted a pan-cancer analysis to investigate molecular mechanisms DLX4, with particular emphasis on role renal cancer. A comprehensive was performed, focusing differences expression, prognostic value, somatic mutations, methylation modifications, and immune landscapes across various types using multiple databases. Gene Ontology Kyoto Encyclopedia Genes Genomes analyses were utilized explore potential biological functions. Additionally, evaluated expression profile, significance, infiltration Kidney Renal Clear Cell Carcinoma (KIRC). The effect KIRC further validated by Spatial Transcriptomics, Real-time PCR (RT-PCR), Immunohistochemistry experiments. found be upregulated 26 associated poor prognosis. It also correlated tumor mutational burden (TMB), microsatellite instability, mismatch repair, methylation, significantly enriched pathways related cell proliferation. In KIRC, increased along TMB scores, likely due regulatory T cells (Tregs) T-helper 2 (Th2) cells. transcriptomics revealed strong correlation between localization Experimental validation confirmed that tissues. Our study explored pan-cancer, especially clear carcinoma, identifying it as promising biomarker therapeutic target.

Язык: Английский

Процитировано

0
Exploring the Anticancer Potential of Furanpydone A: A Computational Study on its Inhibition of MTHFD2 Across Diverse Cancer Cell Lines DOI
Maram B. Alhawarri

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown

Опубликована: Авг. 7, 2024

Язык: Английский

Процитировано

4
Autophagy-Targeted Platinum(IV) Agents: A New Horizon in Antitumor Drug Development DOI
Suying Li, Yan Chen,

Shuaiqi Feng

и другие.

Dalton Transactions, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The recent progress of Pt( iv ) agents with autophagy-promoting or -inhibiting properties as antitumor has been reviewed.

Язык: Английский

Процитировано

0
IgG4-mediated M2 macrophage polarization in tertiary lymphoid structures of esophageal cancer: implications for immunosuppression DOI Creative Commons
Hui Wang, Jirui Li, Wang Yinghai

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 17, 2025

Our previous research highlighted the potential role of immunoglobulin G4 (IgG4) in mediating immunosuppression within tumor microenvironment (TME). Tertiary lymphoid structures (TLS) TME have important immune-related functions. This study aims to analyze distribution characteristics IgG4-expressing cells, regulatory T cells (Tregs), and M2-type macrophages as well elucidate relationship between IgG4 polarization M2 TLS esophageal cancer. To IgG4, Treg assess impact on macrophage polarization. Esophageal cancer tissue were analyzed with multiplex immunofluorescence determine spatial density B their subtypes. The CD8+ TLS, along interleukin-10 (IL-10) expression presence, was studied. Serum IL-10 levels compared patients healthy controls. In vitro, monocyte differentiation into observed. inversely related mature indicating a immunosuppressive (P<0.05,*). analysis revealed that both (P<0.01, **) (P<0.0001, ****) significantly elevated positively correlated controls **). vitro experiments confirmed macrophages, potentially enhancing phenotype TLS. may contribute by promoting which could be therapeutic target.

Язык: Английский

Процитировано

0
Reverse-engineering the FLT3-PI3K/AKT axis to enhance TILs function and improve prognosis in ovarian and cervical cancers DOI Creative Commons
Hao Feng, Yan Zhang,

Lili Shen

и другие.

Journal of Ovarian Research, Год журнала: 2025, Номер 18(1)

Опубликована: Янв. 25, 2025

Ovarian cancers (OC) and cervical (CC) have poor survival rates. Tumor-infiltrating lymphocytes (TILs) play a pivotal role in prognosis, but shared immune mechanisms remain elusive. We integrated single-cell RNA sequencing (scRNA-seq) spatial transcriptomics (ST) to explore regulation OC CC, focusing on the PI3K/AKT pathway FLT3 as key modulators. Seurat Harmony were employed for batch correction dimensionality reduction. expression was mapped with data from 10 × Genomics. FLT3, identified regulator through pathway, showed positive correlations T cells, NK B cells. FLT3-high regions exhibited increased infiltration, particularly enhancing outcomes. This study provides first spatially resolved evidence of FLT3's immune-modulatory positioning it promising immunotherapeutic target. FLT3-targeted strategies may offer new options patients resistant conventional therapies.

Язык: Английский

Процитировано

0