Biochemical Pharmacology, Год журнала: 2025, Номер 236, С. 116887 - 116887
Опубликована: Март 20, 2025
Язык: Английский
Clinical Science, Год журнала: 2025, Номер 139(02), С. 151 - 169
Опубликована: Янв. 1, 2025
Lactylation, a post-translational modification, has been linked to gene transcription regulation through epigenetic modulation in various pathophysiological processes. The lactylation regulatory proteins, known as writers, erasers, and readers, govern their dynamics by adding, removing, recognizing lactyl groups on proteins. Macrophages, cells of the immune system, maintain homeostasis, responding dynamically diverse internal external stimuli. Emerging researches unveil that lactylation, inducing macrophage activation polarization, affects functionality pathological conditions such inflammation, tumor microenvironment, fibrosis. Evidence progressively indicates lactate-driven alterations levels within macrophages can influence pathogenesis numerous diseases. This review aims systematically summarize research progress macrophages, explore its functions mechanisms which contributes pathology different disease phenotypes, propose future directions along with potential diagnostic therapeutic strategies.
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 14, 2025
Metabolic reprogramming is one of the major biological features malignant tumors, playing a crucial role in initiation and progression cancer. The tumor microenvironment consists various non-cancer cells, such as hepatic stellate cancer-associated fibroblasts (CAFs), immune well extracellular matrix soluble substances. In liver cancer, metabolic not only affects its own growth survival but also interacts with other cells by influencing expression release metabolites cytokines (such lactate, PGE2, arginine). This interaction leads to acidification restricts uptake nutrients resulting competition symbiosis. At same time, neighboring during proliferation differentiation processes impacts immunity. article provides comprehensive overview crosstalk between cancer their microenvironment, deepening our understanding relevant findings pathways. contributes further regulation development evasion mechanisms while providing assistance advancing personalized therapies targeting pathways for anti-cancer treatment.
Язык: Английский
Процитировано
1
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217567 - 217567
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217509 - 217509
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 18, 2025
Liver cancer, particularly hepatocellular carcinoma (HCC), is one of the most common and aggressive malignancies worldwide. Immunotherapy has shown promising results in treating HCC, but its efficacy often limited by complex mechanisms immune evasion. Post-translational modifications (PTMs) proteins play a critical role regulating responses within tumor microenvironment (TME). These influence protein function, stability, interactions, which either promote or inhibit cell activity cancer. In this mini-review, we explore diverse PTMs that impact evasion liver including glycosylation, phosphorylation, acetylation, ubiquitination. We focus on how these regulate key checkpoint molecules such as PD-L1, CTLA-4, TCR complex. Furthermore, discuss potential targeting combination with existing immunotherapies to enhance effectiveness treatment HCC. Understanding regulation may lead development novel therapeutic strategies overcome resistance immunotherapy
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117934 - 117934
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
0
Experimental Hematology and Oncology, Год журнала: 2025, Номер 14(1)
Опубликована: Март 8, 2025
Cancer remains the leading cause of mortality worldwide, and emergence drug resistance has made identification new therapeutic targets imperative. Lactate, traditionally viewed as a byproduct glycolysis with limited ATP-producing capacity, recently gained recognition critical signaling molecule. It plays key role not only in cancer cell metabolism but also shaping tumor microenvironment (TME). Histone lysine lactylation, newly identified post-translational modification, been shown to influence range cellular processes cancer. Current research focuses on mechanisms functions histone lactylation cancer, including its gene expression regulation, signal transduction, protein synthesis. However, despite these advancements, there are still plenty barriers quest unravel modification. The single-cell spatial transcriptomics may offer valuable insights for selecting targets. This review provides comprehensive summary applications modification clinical settings. Through detailed analysis, we identify challenges limitations that exist current landscape. These lay groundwork future studies by highlighting promising directions.
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119648 - 119648
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Biochemical Pharmacology, Год журнала: 2025, Номер 236, С. 116887 - 116887
Опубликована: Март 20, 2025
Язык: Английский
Процитировано
0