Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer
Seminars in Cancer Biology,
Год журнала:
2024,
Номер
106-107, С. 43 - 57
Опубликована: Авг. 29, 2024
Язык: Английский
Osalmid sensitizes clear cell Renal Cell Carcinoma to navitoclax through a STAT3/BCL-XL pathway
Cancer Letters,
Год журнала:
2025,
Номер
613, С. 217514 - 217514
Опубликована: Янв. 31, 2025
Язык: Английский
Effects of Hsa-miR-4741/LILRB2 on Senescence of Nucleus Pulposus Cells and Their Prognostic Values in Lumbar Disc Herniation
Journal of Investigative Surgery,
Год журнала:
2025,
Номер
38(1)
Опубликована: Фев. 2, 2025
The
incidence
of
lumbar
disk
herniation
(LDH)
is
usually
caused
by
degeneration.
Surgery
a
common
treatment
strategy
for
LDH,
but
it
can
recur,
resulting
in
recurrent
(RDH).
To
explore
the
predictive
value
hsa-miR-4741
and
LILRB2
prognosis
LDH
surgery
mechanism
nucleus
pulposus
senescence.
ROC
curves
RDH
based
on
were
constructed
to
evaluate
their
values
surgery.
Human
cells
(NPC)
was
treated
TNF-α
construct
cell
senescence
model,
studying
mechanism.
Oxidative
stress
markers
detected
after
overexpression
effects
NPC.
Dual
luciferase
assay
transfection
mimics
or
inhibitor
used
investigate
targeted
regulation
LILRB2.
combination
showed
higher
accuracy
predicting
outcome
(AUC
=
0.9367),
compared
with
single
molecule.
Overexpression
enhanced
TNF-α-induced
oxidative
senescence,
while
had
opposite
effect.
Hsa-miR-4741
attenuated
activity
NPC
transfected
wt-LILRB2
vector
significantly
down-regulated
expression.
In
addition,
antioxidant
NAC
reversed
promotion
good
predictor
prognosis.
promoted
stress-induced
negatively
regulating
Язык: Английский
Targeting leukocyte immunoglobulin‑like receptor B2 in the tumor microenvironment: A new treatment prospect for solid tumors (Review)
Oncology Letters,
Год журнала:
2025,
Номер
29(4)
Опубликована: Фев. 12, 2025
Leukocyte
immunoglobulin-like
receptor
B2
(LILRB2)
functions
as
an
immunosuppressive
that
has
a
prominent
role
in
immune
regulation.
The
expression
of
LILRB2
is
higher
variety
solid
malignant
tumors
compared
with
corresponding
normal
tissues.
can
be
expressed
tumor
cells
and
stromal
within
the
microenvironment.
Upregulation
significantly
associated
poorer
phenotype,
increased
tolerance
to
certain
therapeutic
drugs,
escape
shorter
patient
overall
survival
time.
Therefore,
utilized
novel
biomarker
predict
prognosis
patients
tumors,
targeting
may
effective
strategy
for
targeted
cancer
therapy.
present
review
provides
general
overview
mechanisms
microenvironment
emphasizes
significance
promising
approach
tumor-specific
Язык: Английский
Identification of RASL11A as a gene conferring radiosensitivity in glioblastoma
Journal of Neuro-Oncology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
A bibliometric and visual analysis of the impact of senescence on tumor immunotherapy
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 11, 2025
Background
Recently,
many
studies
have
focused
on
the
relationship
between
senescence
and
immunotherapy
in
cancer
treatment.
However,
relatively
few
examined
intrinsic
links
three.
Whether
these
can
act
synergistically
fight
against
specific
them
are
still
unclear.
Methods
We
extracted,
quantified,
visualized
data
from
literature
(n
=
2396)
for
period
2004-2023
after
rigorous
quality
control
using
citespace,
GraphPad
Prism,
R
software
package,
VOSviewer.
Results
Linear
fit
analyses
were
generated
to
predict
number
of
annual
publications
citations
as
a
function
top-performing
authors,
journals,
countries,
affiliations
academically
over
past
two
decades
such
Weiwei,
Aging-us,
China,
UT
MD
Anderson
Cancer
Center.
Vosviewer-based
hierarchical
clustering
further
categorized
study
characteristics
into
six
clusters,
including
major
clusters
research,
immunosenescence-related
research
factors,
timeline
distributions
suggesting
that
cellular
tumor
progression
is
new
cluster
warrants
exploration
development.
Study
characterization
bursts
linear
regression
confirmed
findings
revealed
other
important
results,
aging
(a
1.964,
R²
0.6803)
16.38,
0.8812).
Furthermore,
gene
frequency
analysis
this
most
abundant
gene,
APOE
,
SIRT1-7
proteins.
Conclusion
The
combination
therapies
with
immunotherapies
currently
its
preliminary
stages.
Although
has
greatest
impact
ICB
therapies,
mechanistic
investigations,
drug
development
sirt1-7
(Sirtuins
family)
targets
may
be
key
combining
treatment
tumors.
Язык: Английский