A bibliometric and visual analysis of the impact of senescence on tumor immunotherapy DOI Creative Commons
Zixu Liu,

Y. J. Mao,

Shukai Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 11, 2025

Background Recently, many studies have focused on the relationship between senescence and immunotherapy in cancer treatment. However, relatively few examined intrinsic links three. Whether these can act synergistically fight against specific them are still unclear. Methods We extracted, quantified, visualized data from literature (n = 2396) for period 2004-2023 after rigorous quality control using citespace, GraphPad Prism, R software package, VOSviewer. Results Linear fit analyses were generated to predict number of annual publications citations as a function top-performing authors, journals, countries, affiliations academically over past two decades such Weiwei, Aging-us, China, UT MD Anderson Cancer Center. Vosviewer-based hierarchical clustering further categorized study characteristics into six clusters, including major clusters research, immunosenescence-related research factors, timeline distributions suggesting that cellular tumor progression is new cluster warrants exploration development. Study characterization bursts linear regression confirmed findings revealed other important results, aging (a 1.964, R² 0.6803) 16.38, 0.8812). Furthermore, gene frequency analysis this most abundant gene, APOE , SIRT1-7 proteins. Conclusion The combination therapies with immunotherapies currently its preliminary stages. Although has greatest impact ICB therapies, mechanistic investigations, drug development sirt1-7 (Sirtuins family) targets may be key combining treatment tumors.

Language: Английский

Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer DOI
Ming Gu, Yang Liu, Wenhui Zheng

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 43 - 57

Published: Aug. 29, 2024

Language: Английский

Citations

11
Osalmid sensitizes clear cell Renal Cell Carcinoma to navitoclax through a STAT3/BCL-XL pathway DOI Creative Commons
Yizheng Xue, Tianyi Chen, Z. Ma

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 613, P. 217514 - 217514

Published: Jan. 31, 2025

Language: Английский

Citations

0
Effects of Hsa-miR-4741/LILRB2 on Senescence of Nucleus Pulposus Cells and Their Prognostic Values in Lumbar Disc Herniation DOI Creative Commons
Ziwen He, Nanfeng Zheng,

Xiu-Quan Guo

et al.

Journal of Investigative Surgery, Journal Year: 2025, Volume and Issue: 38(1)

Published: Feb. 2, 2025

The incidence of lumbar disk herniation (LDH) is usually caused by degeneration. Surgery a common treatment strategy for LDH, but it can recur, resulting in recurrent (RDH). To explore the predictive value hsa-miR-4741 and LILRB2 prognosis LDH surgery mechanism nucleus pulposus senescence. ROC curves RDH based on were constructed to evaluate their values surgery. Human cells (NPC) was treated TNF-α construct cell senescence model, studying mechanism. Oxidative stress markers detected after overexpression effects NPC. Dual luciferase assay transfection mimics or inhibitor used investigate targeted regulation LILRB2. combination showed higher accuracy predicting outcome (AUC = 0.9367), compared with single molecule. Overexpression enhanced TNF-α-induced oxidative senescence, while had opposite effect. Hsa-miR-4741 attenuated activity NPC transfected wt-LILRB2 vector significantly down-regulated expression. In addition, antioxidant NAC reversed promotion good predictor prognosis. promoted stress-induced negatively regulating

Language: Английский

Citations

0
Targeting leukocyte immunoglobulin‑like receptor B2 in the tumor microenvironment: A new treatment prospect for solid tumors (Review) DOI Open Access
Meng Cao,

Jing Luan,

Cui Zhai

et al.

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(4)

Published: Feb. 12, 2025

Leukocyte immunoglobulin-like receptor B2 (LILRB2) functions as an immunosuppressive that has a prominent role in immune regulation. The expression of LILRB2 is higher variety solid malignant tumors compared with corresponding normal tissues. can be expressed tumor cells and stromal within the microenvironment. Upregulation significantly associated poorer phenotype, increased tolerance to certain therapeutic drugs, escape shorter patient overall survival time. Therefore, utilized novel biomarker predict prognosis patients tumors, targeting may effective strategy for targeted cancer therapy. present review provides general overview mechanisms microenvironment emphasizes significance promising approach tumor-specific

Language: Английский

Citations

0
Identification of RASL11A as a gene conferring radiosensitivity in glioblastoma DOI
Ruilong Lan, Na Zhang, Ruiqing Chen

et al.

Journal of Neuro-Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
A bibliometric and visual analysis of the impact of senescence on tumor immunotherapy DOI Creative Commons
Zixu Liu,

Y. J. Mao,

Shukai Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 11, 2025

Background Recently, many studies have focused on the relationship between senescence and immunotherapy in cancer treatment. However, relatively few examined intrinsic links three. Whether these can act synergistically fight against specific them are still unclear. Methods We extracted, quantified, visualized data from literature (n = 2396) for period 2004-2023 after rigorous quality control using citespace, GraphPad Prism, R software package, VOSviewer. Results Linear fit analyses were generated to predict number of annual publications citations as a function top-performing authors, journals, countries, affiliations academically over past two decades such Weiwei, Aging-us, China, UT MD Anderson Cancer Center. Vosviewer-based hierarchical clustering further categorized study characteristics into six clusters, including major clusters research, immunosenescence-related research factors, timeline distributions suggesting that cellular tumor progression is new cluster warrants exploration development. Study characterization bursts linear regression confirmed findings revealed other important results, aging (a 1.964, R² 0.6803) 16.38, 0.8812). Furthermore, gene frequency analysis this most abundant gene, APOE , SIRT1-7 proteins. Conclusion The combination therapies with immunotherapies currently its preliminary stages. Although has greatest impact ICB therapies, mechanistic investigations, drug development sirt1-7 (Sirtuins family) targets may be key combining treatment tumors.

Language: Английский

Citations

0