Cited by PD-L1 upregulation in activated fibroblasts promotes silica particle-induced pulmonary fibrosis

The role of cancer-associated fibroblasts and exosomal miRNAs-mediated intercellular communication in the tumor microenvironment and the biology of carcinogenesis: a systematic review DOI

Reza Nedaeinia,

Simin Najafgholian,

Rasoul Salehi

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Aug. 26, 2024

Abstract CAFs (cancer-associated fibroblasts) are highly flexible cells of the cancer microenvironment. They produce extracellular matrix (ECM) constituents that form structure tumor stroma but also a source metabolites, growth factors, chemokines, and exosomes impact every aspect tumor, including its response to treatment. It is believed exosomal miRNAs facilitate intercellular signaling, which essential for development cancer. The role in microenvironment (TME) carcinogenesis reviewed this paper. preferred reporting items systematic reviews meta-analyses (PRISMA) 2020 guidelines were used perform review. Several databases, Web Science, Medline, Embase, Cochrane Library, Scopus, searched using following keywords: CAFs, CAF, cancer-associated fibroblasts, stromal miRNA, miRNAs, exosome similar terms. We identified studies investigating TME their carcinogenesis. A total 12,572 papers identified. After removing duplicates ( n = 3803), 8774 articles screened by title abstract. Of these, 421 excluded from further analysis. has been reported if not functioning correctly, may influence secretory phenotype tip contribute increased invasiveness, spread, decreased treatment efficacy, poorer prognosis. Under influence, normal fibroblasts (NFs) transformed into CAFs. Furthermore, they participate metabolic reprogramming, allows fast proliferation cell population, adaptation growing energy demands, capacity avoid immune system identification.

Language: Английский

Citations

TBX3 shapes an immunosuppressive microenvironment and induces immunotherapy resistance DOI

Zhi Liu, Chunyu Zhang,

Jiatong Xiao

et al.

Theranostics, Journal Year: 2025, Volume and Issue: 15(5), P. 1966 - 1986

Published: Jan. 6, 2025

Background: Identifying biomarkers that predict immunotherapy efficacy and discovering new targets for combination therapies are critical elements improving the prognosis of bladder cancer (BLCA) patients. Methods: Firstly, we explored expression patterns TBX3 in normal pan-cancer tissues correlation between immune microenvironment using data from multiple public databases. Then, combined various techniques, including bulk RNA sequencing, single-cell high-throughput cytokine arrays, functional experiments, ProcartaPlex multiplex immunoassays TissueFAXS panoramic tissue quantification assays, to demonstrate shapes an immunosuppressive tumor (TME) BLCA. Results: We identified as a key factor associated with BLCA through systematic multi-omics analysis. found is primarily expressed malignant cells, where TBX3high cells increase secretion TGFβ1, which promotes infiltration cancer-associated fibroblasts (CAFs), thereby forming microenvironment. further demonstrated enhances TGFβ1 by binding promoter, blocking counteracts effects TBX3. Moreover, reduced cancer-killing efficiency CD8+ T decreasing proportion GZMB+ knocking down anti-PD-1 treatment increased cell CAFs vivo. also validated inverse relationship TBX3+ positive microarrays. Lastly, predicted our real-world cohort cohorts. Conclusion: In summary, progression resistance inducing microenvironment, targeting could enhance

Language: Английский

Citations

Focus on mechano-immunology: new direction in cancer treatment DOI

Lin Zhao,

Yajun Gui,

Xiangying Deng

et al.

International Journal of Surgery, Journal Year: 2025, Volume and Issue: 111(3), P. 2590 - 2602

Published: Jan. 7, 2025

The immune response is modulated by a diverse array of signals within the tissue microenvironment, encompassing biochemical factors, mechanical forces, and pressures from adjacent tissues. Furthermore, extracellular matrix its constituents significantly influence function cells. In case carcinogenesis, changes in biophysical properties tissues can impact received cells, these c1an be translated into through mechano-transduction pathways. These pathways have profound on cellular functions, influencing processes such as cell activation, metabolism, proliferation, migration, etc. Tissue mechanics may undergo temporal during process offering potential for novel dynamic levels regulation. Here, we review advances mechanoimmunology malignancy studies, focusing how mechanosignals modulate behaviors cells at level, thereby triggering an that ultimately influences development progression malignant tumors. Additionally, also focused mechano-immunoengineering systems, with help which could to further understand tumor or alterations microenvironment provide new research directions overcoming immunotherapeutic resistance

Language: Английский

Citations

Modulation of N-glycosylation in the PD-1: PD-L1 axis as a strategy to enhance cancer immunotherapies DOI

Monika Granica, Gustaw Laskowski, Paweł Link-Lenczowski

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189274 - 189274

Published: Jan. 1, 2025

Language: Английский

Citations

EBF1-induced CSRP2 boosts the progression of B-cell acute lymphocytic leukemia by inhibiting ferroptosis DOI

Chengcheng Liu, Gexiu Liu,

Fenling Zhou

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 614, P. 217556 - 217556

Published: Feb. 12, 2025

Language: Английский

Citations

Exploring Immune Checkpoint Inhibitors: Focus on PD-1/PD-L1 Axis and Beyond DOI

Durre Aden, Samreen Zaheer, Niti Sureka

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: 269, P. 155864 - 155864

Published: March 1, 2025

Language: Английский

Citations

The multifaceted role of phosphodiesterase 4 in tumor: from tumorigenesis to immunotherapy DOI

Huimin Ren,

Shaohui Zhang, Peiyuan Li

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 10, 2025

Phosphodiesterase 4 (PDE4) is an enzyme that specifically hydrolyzes the second messenger cAMP and has a critical role in regulation of variety cellular functions. In recent years, PDE4 attracted great interest cancer research, its tumorigenesis development been gradually elucidated. Research indicates abnormal expression or heightened activity associated with initiation progression multiple cancers, including lung, colorectal, hematological by facilitating cell proliferation, migration, invasion, anti-apoptosis. Moreover, also influences tumor immune microenvironment, significantly evasion suppressing anti-tumor responses, reducing T-cell activation, promoting polarization tumor-associated macrophages toward pro-tumorigenic phenotype. However, family may have both oncogenic tumor-suppressive effects, which could depend on specific type grade tumor. inhibitors garnered substantial as potential anti-cancer therapeutics, directly inhibiting growth restoring surveillance capabilities to enhance clearance cells. Several are currently under investigation aim exploring their therapy, particularly combination strategies checkpoint inhibitors, improve therapeutic efficacy mitigate side effects conventional chemotherapy. This review provides overview tumorigenesis, drug resistance, immunotherapy, actions intending guide exploration new target therapy.

Language: Английский

Citations

Comparable Survival Outcomes in HLA-Matched and Haploidentical Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia Patients Aged 40-50: A CBMTR Registry-Based Propensity Score Matching Analysis Over the Last Decade DOI

Zhengli Xu, Yuping Zhang, Baodong Ye

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217594 - 217594

Published: March 1, 2025

Language: Английский

Citations

MEF2A is a transcription factor for circPVT1 and contributes to the malignancy of acute myeloid leukemia DOI

Kun Wu,

Yuntao Li, Bo Nie

et al.

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 65(5)

Published: Sept. 25, 2024

Acute myeloid leukemia (AML) is a hematological malignancy with high relapse rate and poor survival rate. The circular RNA circPVT1 myocyte enhancer factor 2A (MEF2A) have unique functions in the progression of AML; however, underlying mechanisms clinical significance remain to be clarified. Bioinformatics database analyses were used assess transcription factors target genes circPVT1. Dual‑luciferase reporter gene argonaute 2‑RNA immunoprecipitation assays verify targeted relationships. expression levels related proteins detected by reverse transcription‑quantitative PCR western blotting. Cell viability apoptosis Counting Kit‑8 assay flow cytometry, respectively. results revealed that was highly expressed AML samples cell lines, MEF2A regulated overexpression promoted epithelial‑mesenchymal transition (EMT), inhibited apoptosis. In addition, regulation microRNA (miR)‑455‑3p, miR‑455‑3p MCL1 expression, thus indicating through its interaction miR‑455‑3p. Furthermore, cells transfected small interfering RNA‑(si)‑circPVT1, inhibitor or si‑MCL1, si‑circPVT1 si‑MCL1 EMT NB4 HL‑60 cells. However, had opposite effect on conclusion, may act as promote malignant process AML, knockdown could inhibit miR‑455‑3p/MCL1 axis.

Language: Английский

Citations

Biphasic co-detection of melanoma aneuploid tumor cells and tumor endothelial cells in guidance of specifying the field cancerized surgical excision margin and administering immunotherapy DOI

Zhengzheng Fu, Lína Zhang,

Rongyi Chen

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217099 - 217099

Published: July 4, 2024

An optimum safety excision margin (EM) delineated by precise demarcation of field cancerization along with reliable biomarkers that enable predicting and timely evaluating patients' response to immunotherapy significantly impact effective management melanoma. In this study, optimized biphasic "immunofluorescence staining integrated fluorescence insitu hybridization" (iFISH) was conducted the diagnosis-metastasis-treatment-cellular MRD axis longitudinally co-detect a full spectrum intact CD31

Language: Английский

Citations