A 3D printed polylactic acid-Baghdadite nanocomposite scaffold coated with microporous chitosan-VEGF for bone regeneration applications

Carbohydrate Polymers, Год журнала: 2023, Номер 312, С. 120787 - 120787

Опубликована: Март 9, 2023

Язык: Английский

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Natural polymers in wound healing: From academic studies to commercial products

Journal of Applied Polymer Science, Год журнала: 2023, Номер 140(22)

Опубликована: Апрель 12, 2023

Abstract Natural biopolymers (carbohydrates and proteins) are the family of natural polymers that widely used in wound healing. This is due to their biocompatibility chemical structural similarity extracellular matrix (ECM). Wound healing a complex process requires multidisciplinary approach appropriate treatment product enable full recovery. Chronic nonhealing wounds significantly caused reduction. Currently, diabetic considered unmet clinical need new effective will benefit patients economy. research was aimed critically review both literature as well industrial products carbohydrates proteins dressing for wound. The outcome chitosan (CS), carbohydrate, has most application it readily available affordable, shown excellent antibacterial activity. Among proteins, keratin (Kr) can be an option with similar characteristics, however, Kr not yet found use when compared CS.

Язык: Английский

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Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 237, С. 123944 - 123944

Опубликована: Март 9, 2023

Язык: Английский

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Designing biomimetic scaffolds for skin tissue engineering

Biomaterials Science, Год журнала: 2023, Номер 11(9), С. 3051 - 3076

Опубликована: Янв. 1, 2023

This review offers systematic considerations of material design principles and fabrication techniques for biomimetic skin tissue engineering scaffolds.

Язык: Английский

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Angiogenesis, hemocompatibility and bactericidal effect of bioactive natural polymer‐based bilayer adhesive skin substitute for infected burned wound healing

Bioactive Materials, Год журнала: 2023, Номер 29, С. 177 - 195

Опубликована: Июль 15, 2023

Thermal wounds are complex and lethal with irregular shapes, risk of infection, slow healing, large surface area. The mortality rate in patients infected burns is twice that non-infected burns. Developing multifunctional skin substitutes to augment the healing vital. Herein, we 3D printed a hydrogel scaffold comprising carboxymethyl chitosan (CMCs) oxidized alginate grafted catechol (O-AlgCat) on hydrophobic electrospun layer, forming bilayer substitute (BSS). functional layer (FL) was fabricated by physiochemical crosslinking ensure favorable biodegradability. gallium-containing or backing (BL) could mimic epidermis skin, avoiding fluid penetration offering antibacterial activity. FL contains catechol, gallium, biologically active platelet rich fibrin (PRF) adhere both tissue BL, show activity, encourage angiogenesis, cell growth, migration. bioactive BSS exhibited noticeable adhesive properties (P ≤ 0.05), significant activity faster clot formation, potential promote proliferation 0.05) migration L929 cells. Furthermore, angiogenesis significantly higher when evaluated vivo ovo. BSS-covered healed due low inflammation high collagen density. Based obtained results, be an effective treatment for burn wounds.

Язык: Английский

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Mupirocin loaded core-shell pluronic-pectin-keratin nanofibers improve human keratinocytes behavior, angiogenic activity and wound healing

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126700 - 126700

Опубликована: Сен. 4, 2023

Язык: Английский

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Core-shell nanofibers containing L-arginine stimulates angiogenesis and full thickness dermal wound repair

International Journal of Pharmaceutics, Год журнала: 2024, Номер 653, С. 123931 - 123931

Опубликована: Фев. 20, 2024

Язык: Английский

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Recent progress of electrospun nanofibers as burning dressings

RSC Advances, Год журнала: 2024, Номер 14(20), С. 14374 - 14391

Опубликована: Янв. 1, 2024

Burns are a global public health problem, which brings great challenges to and the economy.

Язык: Английский

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Glucose-Responsive Self-Healing Bilayer Drug Microneedles Promote Diabetic Wound Healing Via a Trojan-Horse Strategy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(19), С. 24351 - 24371

Опубликована: Май 1, 2024

Chronic nonhealing wounds are serious complications of diabetes with a high morbidity, and they can lead to disability or death. Conventional drug therapy is ineffective for diabetic wound healing because the complex environment depth penetration. Here, we developed self-healing, dual-layer, drug-carrying microneedle (SDDMN) healing. This SDDMN realize transdermal delivery broad-spectrum sterilization without resistance meets multiple needs process. Quaternary ammonium chitosan cografted dihydrocaffeic acid (Da) l-arginine oxidized hyaluronic acid-dopamine main parts self-healing hydrogel patch. Methacrylated poly(vinyl alcohol) (methacrylated PVA) phenylboronic (PBA) were used as part MN, gallium porphyrin modified 3-amino-1,2 propanediol (POGa) insulin encapsulated at its tip. Under hyperglycaemic conditions, PBA moiety in MN reversibly formed glucose-boronic that promoted rapid release POGa insulin. disguised hemoglobin through Trojan-horse strategy, which then taken up by bacteria, allowing it target bacteria infected lesions. Based on synergistic properties these components, SDDMN-POGa patches exhibited an excellent biocompatibility, slow release, antimicrobial properties. Thus, provide potential therapeutic approach treatment wounds.

Язык: Английский

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Highly Porous 3D Printed Scaffold Incorporated with Graphene Oxide-Merwinite and Coated with IGF1 Loaded Nanofibers for Calvarial Defect Repair

Journal of Polymers and the Environment, Год журнала: 2024, Номер 32(10), С. 5330 - 5343

Опубликована: Май 28, 2024

Язык: Английский

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