Journal of Biomaterials Applications,
Год журнала:
2024,
Номер
39(4), С. 377 - 395
Опубликована: Июль 24, 2024
Hydrogels
have
several
characteristics,
including
biocompatibility,
physical
similarity
with
the
skin’s
extracellular
matrix,
and
regeneration
capacity.
Cell
migration
proliferation
are
facilitated
by
natural
polymers
such
as
gelatin
(Gel)
carboxymethyl
cellulose
(CMC).
Gelatin
dressing
acts
a
structural
framework
for
cell
into
wound
area,
stimulating
division
promoting
granulation
tissue
formation.
Omega-3
fatty
acids
from
fish
oil
may
prevent
infection
improve
healing
of
wounds
in
early
stages.
We
studied
preparation
containing
its
ability
to
heal
wounds.
In
this
study,
CMC-Gel
hydrogels
different
concentrations
were
investigated
full-thickness
After
fabrication
using
surfactant
(tween
20)
microemulsion
method
(oil
water),
various
tests
SEM,
Water
uptake
evaluation,
weight
loss,
viability,
blood
compatibility,
vivo
study
rat
cutaneous
modeling
during
14
days
performed
evaluate
properties
fabricated
hydrogels.
The
analysis
revealed
that
they
possess
porous
structures
interconnected
pores,
an
average
size
83.23
±
6.43
μm.
exhibited
swelling
capacity
up
60%
their
initial
within
24
h,
indicated
loss
measurements.
viability
MTT
technique
showed
no
cytotoxicity
was
observed
at
recommended
dosage,
however,
increasing
amount
omega-3
caused
hemolysis,
death,
inhibition
coagulation
activity.
An
adult
male
rats
model
greater
than
91%
improvement
primary
region
after
2
weeks
treatment.
Histological
demonstrated
hydrogels,
which
is
promising
approach
topical
skin
treatment
scar,
has
shown
efficacy
improving
repair
process
defect
site.
Polymers,
Год журнала:
2024,
Номер
16(13), С. 1937 - 1937
Опубликована: Июль 6, 2024
Over
millions
of
years
evolution,
nature
has
developed
a
myriad
unique
features
that
have
inspired
the
design
adhesives
for
wound
healing.
Bionic
hydrogel
adhesives,
capable
adapting
to
dynamic
movements
tissues,
possess
superior
biocompatibility
and
effectively
promote
healing
both
external
internal
wounds.
This
paper
provides
systematic
review
principles
these
focusing
on
treatment
skin
wounds,
explores
feasibility
incorporating
nature-inspired
properties
into
their
design.
The
adhesion
mechanisms
bionic
are
analyzed
from
chemical
physical
perspectives.
Materials
natural
synthetic
polymers
commonly
used
as
detailed
regarding
degradability.
multifunctional
elements
trauma
treatment,
such
self-healing,
drug
release,
responsive
design,
optimization
mechanical
properties,
further
explored.
aim
is
overcome
limitations
conventional
treatments
offer
safer,
more
effective
solution
application
dressings.
Journal of Biomaterials Applications,
Год журнала:
2024,
Номер
39(4), С. 377 - 395
Опубликована: Июль 24, 2024
Hydrogels
have
several
characteristics,
including
biocompatibility,
physical
similarity
with
the
skin’s
extracellular
matrix,
and
regeneration
capacity.
Cell
migration
proliferation
are
facilitated
by
natural
polymers
such
as
gelatin
(Gel)
carboxymethyl
cellulose
(CMC).
Gelatin
dressing
acts
a
structural
framework
for
cell
into
wound
area,
stimulating
division
promoting
granulation
tissue
formation.
Omega-3
fatty
acids
from
fish
oil
may
prevent
infection
improve
healing
of
wounds
in
early
stages.
We
studied
preparation
containing
its
ability
to
heal
wounds.
In
this
study,
CMC-Gel
hydrogels
different
concentrations
were
investigated
full-thickness
After
fabrication
using
surfactant
(tween
20)
microemulsion
method
(oil
water),
various
tests
SEM,
Water
uptake
evaluation,
weight
loss,
viability,
blood
compatibility,
vivo
study
rat
cutaneous
modeling
during
14
days
performed
evaluate
properties
fabricated
hydrogels.
The
analysis
revealed
that
they
possess
porous
structures
interconnected
pores,
an
average
size
83.23
±
6.43
μm.
exhibited
swelling
capacity
up
60%
their
initial
within
24
h,
indicated
loss
measurements.
viability
MTT
technique
showed
no
cytotoxicity
was
observed
at
recommended
dosage,
however,
increasing
amount
omega-3
caused
hemolysis,
death,
inhibition
coagulation
activity.
An
adult
male
rats
model
greater
than
91%
improvement
primary
region
after
2
weeks
treatment.
Histological
demonstrated
hydrogels,
which
is
promising
approach
topical
skin
treatment
scar,
has
shown
efficacy
improving
repair
process
defect
site.
