Development of carboxymethyl cellulose/gelatin hydrogel loaded with Omega-3 for skin regeneration DOI
Sepehr Zamani, Nariman Rezaei Kolarijani,

Mahdi Naeiji

et al.

Journal of Biomaterials Applications, Journal Year: 2024, Volume and Issue: 39(4), P. 377 - 395

Published: July 24, 2024

Hydrogels have several characteristics, including biocompatibility, physical similarity with the skin’s extracellular matrix, and regeneration capacity. Cell migration proliferation are facilitated by natural polymers such as gelatin (Gel) carboxymethyl cellulose (CMC). Gelatin dressing acts a structural framework for cell into wound area, stimulating division promoting granulation tissue formation. Omega-3 fatty acids from fish oil may prevent infection improve healing of wounds in early stages. We studied preparation containing its ability to heal wounds. In this study, CMC-Gel hydrogels different concentrations were investigated full-thickness After fabrication using surfactant (tween 20) microemulsion method (oil water), various tests SEM, Water uptake evaluation, weight loss, viability, blood compatibility, vivo study rat cutaneous modeling during 14 days performed evaluate properties fabricated hydrogels. The analysis revealed that they possess porous structures interconnected pores, an average size 83.23 ± 6.43 μm. exhibited swelling capacity up 60% their initial within 24 h, indicated loss measurements. viability MTT technique showed no cytotoxicity was observed at recommended dosage, however, increasing amount omega-3 caused hemolysis, death, inhibition coagulation activity. An adult male rats model greater than 91% improvement primary region after 2 weeks treatment. Histological demonstrated hydrogels, which is promising approach topical skin treatment scar, has shown efficacy improving repair process defect site.

Language: Английский

Developmental prospects of carrageenan-based wound dressing films: Unveiling techno-functional properties and freeze-drying technology for the development of absorbent films — A review DOI

P Amruth,

P Akshay,

Rosemol Jacob M

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133668 - 133668

Published: July 9, 2024

Language: Английский

Citations

5
Fetal milieu-simulating hyaluronic acid-dopamine-chondroitin sulfate hydrogel promoting angiogenesis and hair regeneration for wound healing DOI

Hehui Rong,

Yating Dong,

Junke Zhao

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 248, P. 125739 - 125739

Published: July 7, 2023

Language: Английский

Citations

12
Self-crosslinking hyaluronic acid hydrogel as an enteroprotective agent for the treatment of inflammatory bowel disease DOI
Guangshuai Zhang, Dandan Song, Ruilong Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132909 - 132909

Published: June 6, 2024

Language: Английский

Citations

4
Principles and Design of Bionic Hydrogel Adhesives for Skin Wound Treatment DOI Open Access

Chunxiao Wang,

Xinyu Zhang,

Yinuo Fan

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(13), P. 1937 - 1937

Published: July 6, 2024

Over millions of years evolution, nature has developed a myriad unique features that have inspired the design adhesives for wound healing. Bionic hydrogel adhesives, capable adapting to dynamic movements tissues, possess superior biocompatibility and effectively promote healing both external internal wounds. This paper provides systematic review principles these focusing on treatment skin wounds, explores feasibility incorporating nature-inspired properties into their design. The adhesion mechanisms bionic are analyzed from chemical physical perspectives. Materials natural synthetic polymers commonly used as detailed regarding degradability. multifunctional elements trauma treatment, such self-healing, drug release, responsive design, optimization mechanical properties, further explored. aim is overcome limitations conventional treatments offer safer, more effective solution application dressings.

Language: Английский

Citations

4
Development of carboxymethyl cellulose/gelatin hydrogel loaded with Omega-3 for skin regeneration DOI
Sepehr Zamani, Nariman Rezaei Kolarijani,

Mahdi Naeiji

et al.

Journal of Biomaterials Applications, Journal Year: 2024, Volume and Issue: 39(4), P. 377 - 395

Published: July 24, 2024

Hydrogels have several characteristics, including biocompatibility, physical similarity with the skin’s extracellular matrix, and regeneration capacity. Cell migration proliferation are facilitated by natural polymers such as gelatin (Gel) carboxymethyl cellulose (CMC). Gelatin dressing acts a structural framework for cell into wound area, stimulating division promoting granulation tissue formation. Omega-3 fatty acids from fish oil may prevent infection improve healing of wounds in early stages. We studied preparation containing its ability to heal wounds. In this study, CMC-Gel hydrogels different concentrations were investigated full-thickness After fabrication using surfactant (tween 20) microemulsion method (oil water), various tests SEM, Water uptake evaluation, weight loss, viability, blood compatibility, vivo study rat cutaneous modeling during 14 days performed evaluate properties fabricated hydrogels. The analysis revealed that they possess porous structures interconnected pores, an average size 83.23 ± 6.43 μm. exhibited swelling capacity up 60% their initial within 24 h, indicated loss measurements. viability MTT technique showed no cytotoxicity was observed at recommended dosage, however, increasing amount omega-3 caused hemolysis, death, inhibition coagulation activity. An adult male rats model greater than 91% improvement primary region after 2 weeks treatment. Histological demonstrated hydrogels, which is promising approach topical skin treatment scar, has shown efficacy improving repair process defect site.

Language: Английский

Citations

4