Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 417 - 417
Опубликована: Март 29, 2024
Radiation-induced
enteritis
is
an
unavoidable
complication
associated
with
pelvic
tumor
radiotherapy,
significantly
influencing
the
prognosis
of
cancer
patients.
The
limited
availability
commercial
gastrointestinal
radioprotectors
in
clinical
settings
poses
a
substantial
challenge
preventing
radiation
enteritis.
Despite
inherent
radioprotective
characteristics
Cur
vitro,
its
poor
solubility
water,
instability,
and
low
bioavailability
lead
to
inferior
therapeutic
effects
vivo.
Herein,
we
developed
novel
ROS-responsive
micelles
(CTI)
from
inulin
curcumin,
aimed
at
mitigating
CTI
had
excellent
stability.
Importantly,
improved
cytotoxicity
thereby
showing
enhanced
effectiveness
neutralizing
ROS
induced
by
radiation,
safeguarding
against
DNA
damage,
reducing
radiation-induced
cellular
mortality.
Moreover,
mice
model,
not
only
alleviated
severe
intestinal
injury
but
also
redox-related
indicators
reduced
inflammatory
cytokine
expression.
Furthermore,
effectively
increased
gut
microbiota
abundance
maintained
homeostasis.
In
conclusion,
could
be
promising
candidate
for
management
Our
study
provides
new
perspective
radioprotection
using
natural
antioxidants.
Gels,
Год журнала:
2024,
Номер
10(9), С. 547 - 547
Опубликована: Авг. 23, 2024
Regenerative
hydrogels
from
natural
polymers
have
come
forth
as
auspicious
materials
for
use
in
regenerative
medicine,
with
interest
attributed
to
their
intrinsic
biodegradability,
biocompatibility,
and
ability
reassemble
the
extracellular
matrix.
This
review
covers
latest
advances
used
wound
healing,
focusing
on
chemical
composition,
cross-linking
mechanisms,
functional
properties.
Key
carbohydrate
polymers,
including
alginate,
chitosan,
hyaluronic
acid,
polysaccharide
gums,
agarose,
carrageenan,
xanthan
gum,
are
discussed
terms
of
sources,
structures
specific
properties
suitable
applications.
The
further
explores
categorization
based
ionic
charge,
response
physiological
stimuli
(i.e.,
pH,
temperature)
particularized
roles
tissue
self-healing.
Various
methods
enhance
mechanical
biological
performance
these
also
examined.
By
highlighting
recent
innovations
ongoing
challenges,
this
article
intends
give
a
detailed
understanding
potential
revolutionize
medicine
improve
patient
healing
outcomes.
Materials & Design,
Год журнала:
2024,
Номер
239, С. 112812 - 112812
Опубликована: Фев. 29, 2024
Surgical
site
infection
(SSI)
is
a
feared
complication
in
liver
resection.
Developing
wound
dressings
that
effectively
combat
bacterial
and
promote
tissue
regeneration
clinically
significant.
Herein,
we
present
near-infrared
(NIR)
light-responsive
multifunctional
hydrogel
system
(PDA/Mup@DA-HA)
consisting
of
mupirocin-loaded
polydopamine
nanoparticles
(PDA)
dopamine-modified
hyaluronic
acid
(DA-HA)
to
accelerate
bacteria-infected
healing.
The
hybrid
has
good
adhesion
three-dimensional
porous
structure,
which
can
adapt
the
shape
for
adequate
hemostasis
provide
suitable
microenvironment
doped
inside
are
uniformly
distributed
have
functions
loading
antibacterial
drugs
photothermal
therapy.
Therefore,
excellent
quickly
attach
infected
wounds
generate
controllable
local
hyperthermia
under
light
irradiation,
induce
destruction
integrity,
increase
effective
release
drug
mupirocin,
thereby
synergistically
leading
inactivation.
Notably,
animal
model
indicates
significantly
healing
caused
by
infections
irradiation
reducing
inflammatory
reactions
promoting
vascular
reconstruction.
dressing
provides
reliable
tool
treating
bacterial-infected
clinical
applications.
