ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
Osteoarthritis
(OA)
is
a
chronic
multifactorial
disease
characterized
by
cartilage
degeneration,
pain,
and
reduced
mobility.
Current
therapies
primarily
aim
to
relieve
pain
restore
function,
but
they
often
have
limited
effectiveness
side
effects.
Coixol,
bioactive
compound
from
Coix
lacryma-jobi
L.,
exhibits
anti-inflammatory
analgesic
properties,
suggesting
potential
benefits
in
OA
treatment.
This
study
explored
the
effects
of
coixol
on
chondrocytes.
Primary
chondrocytes
rats
were
isolated
treated
with
varying
concentrations
coixol.
Cell
viability
proliferation
assessed
using
CCK-8
assays.
The
expression
genes
related
ferroptosis
autophagy
was
analyzed
through
RT-qPCR,
Western
blot,
immunofluorescence.
Moreover,
investigated
characteristics
performance
coixol-loaded
PDLLA–PEG-PDLLA
(PLEL)/gelatin
sponge
(GS)
hydrogels
(Coixol@PLEL/GS)
for
enhancing
osteochondral
defect
repair
specifically
targeting
chondrocyte
autophagy.
PDLLA–PEG-PDLLA/gelatin
evaluated
cryo-scanning
electron
microscopy
(SEM)
or
SEM,
release
kinetics
determined.
In
vivo,
rat
model
used
assess
efficacy
Coixol@PLEL/GS
International
Cartilage
Repair
Society
(ICRS)
scores,
Safranin
O/Fast
green
staining,
Toluidine
blue
Coixol
significantly
increased
dose-dependent
manner.
Furthermore,
inhibited
stimulated
autophagy,
as
evidenced
upregulation
genes.
remarkably
enhanced
defects
compared
that
control
groups.
conclusion,
protects
improving
survival,
inhibiting
ferroptosis,
activating
highlighting
its
therapeutic
strategy
Gels,
Год журнала:
2024,
Номер
10(4), С. 262 - 262
Опубликована: Апрель 13, 2024
Hydrogels,
with
their
distinctive
three-dimensional
networks
of
hydrophilic
polymers,
drive
innovations
across
various
biomedical
applications.
The
ability
hydrogels
to
absorb
and
retain
significant
volumes
water,
coupled
structural
integrity
responsiveness
environmental
stimuli,
renders
them
ideal
for
drug
delivery,
tissue
engineering,
wound
healing.
This
review
delves
into
the
classification
based
on
cross-linking
methods,
providing
insights
synthesis,
properties,
We
further
discuss
recent
advancements
in
hydrogel-based
delivery
systems,
including
oral,
injectable,
topical,
ocular
approaches,
highlighting
significance
enhancing
therapeutic
outcomes.
Additionally,
we
address
challenges
faced
clinical
translation
propose
future
directions
leveraging
potential
personalized
medicine
regenerative
healthcare
solutions.
Advanced Materials,
Год журнала:
2024,
Номер
36(21)
Опубликована: Фев. 16, 2024
Immunotherapy
represents
a
revolutionary
paradigm
in
cancer
management,
showcasing
its
potential
to
impede
tumor
metastasis
and
recurrence.
Nonetheless,
challenges
including
limited
therapeutic
efficacy
severe
immune-related
side
effects
are
frequently
encountered,
especially
solid
tumors.
Hydrogels,
class
of
versatile
materials
featuring
well-hydrated
structures
widely
used
biomedicine,
offer
promising
platform
for
encapsulating
releasing
small
molecule
drugs,
biomacromolecules,
cells
controlled
manner.
Immunomodulatory
hydrogels
present
unique
capability
augmenting
immune
activation
mitigating
systemic
toxicity
through
encapsulation
multiple
components
localized
administration.
Notably,
based
on
biopolymers
have
gained
significant
interest
owing
their
biocompatibility,
environmental
friendliness,
ease
production.
This
review
delves
into
the
recent
advances
bio-based
immunotherapy
synergistic
combinatorial
approaches,
highlighting
diverse
applications.
It
is
anticipated
that
this
will
guide
rational
design
field
immunotherapy,
fostering
clinical
translation
ultimately
benefiting
patients.
Bioactive Materials,
Год журнала:
2024,
Номер
40, С. 597 - 623
Опубликована: Авг. 15, 2024
Tissue
engineering
technology
has
advanced
rapidly
in
recent
years,
offering
opportunities
to
construct
biologically
active
tissues
or
organ
substitutes
repair
even
enhance
the
functions
of
diseased
and
organs.
Tissue-engineered
scaffolds
rebuild
extracellular
microenvironment
by
mimicking
matrix.
Fibrin-based
possess
numerous
advantages,
including
hemostasis,
high
biocompatibility,
good
degradability.
Fibrin
provide
an
initial
matrix
that
facilitates
cell
migration,
differentiation,
proliferation,
adhesion,
also
play
a
critical
role
cell-matrix
interactions.
are
now
widely
recognized
as
key
component
tissue
engineering,
where
they
can
facilitate
defect
repair.
This
review
introduces
properties
fibrin,
its
composition,
structure,
biology.
In
addition,
modification
cross-linking
modes
fibrin
discussed,
along
with
various
forms
commonly
used
engineering.
We
describe
biofunctionalization
fibrin.
provides
detailed
overview
use
applications
skin,
bone,
nervous
tissues,
novel
insights
into
future
research
directions
for
clinical
treatment.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 16, 2024
Topical
drug
delivery
is
widely
used
in
various
diseases
because
of
the
advantages
not
passing
through
gastrointestinal
tract,
avoiding
irritation
and
hepatic
first-pass
effect,
reaching
lesion
directly
to
reduce
unnecessary
adverse
reactions.
The
skin
helps
organism
defend
itself
against
a
huge
majority
external
aggressions
one
most
important
lines
defense
body.
However,
skin’s
strong
barrier
ability
also
obstacle
effectiveness
topical
medications.
Allowing
bioactive,
composition
pass
stratum
corneum
as
needed
reach
target
site
essential
need
for
exert
its
therapeutic
effect.
state
barrier,
choice
system
composition,
individualized
disease
detection
dosing
planning
influence
Nowadays,
enhancing
transdermal
absorption
topically
applied
drugs
hottest
research
area.
first
improve
all
drugs.
Excessive
enhances
accumulation
at
non-target
sites
occurrence
This
paper
introduces
strategies
from
three
perspectives:
delivery,
describes
current
status
shortcomings
research,
provides
new
directions
ideas
research.
Giant,
Год журнала:
2024,
Номер
19, С. 100299 - 100299
Опубликована: Июнь 5, 2024
In
the
era
of
smart
and
sustainable
technology
driven
by
naturally
occurring
materials,
various
nanocellulose-based
materials
play
a
crucial
role.
Shape
memory
behaviour
self-healing
capabilities
nanocelluloses
are
emerging
as
focal
points
in
numerous
research
domains.
Nanocellulose
its
derivatives
such
cellulose
nanocrystals
(CNC)
nanofibers
(CNF),
currently
limelight
due
to
their
excellent
shape-memory
properties,
making
them
suitable
for
multifunctional
devices.
this
regard,
CNF,
cutting-edge
material,
has
spurred
researchers
explore
potential
developing
contemporary
personalized
health
Therefore,
timely
comprehensive
review
is
essential
gain
deep
insights
into
effectiveness
CNF
Herein,
we
first
provide
succinct
introduction
all
nanocellulose
materials.
This
also
depicts
recent
advancements
breakthroughs
large
effective
synthesis
CNF-based
hybrid
Next,
focusing
on
performance,
sheds
new
light
advanced
applications
Finally,
perspectives
current
challenges
opportunities
field
summarized
future
an
in-depth
understanding
"CNF-based
materials."
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Abstract
Biopolymer‐based
hydrogels
offer
versatility
in
biomedical
engineering
due
to
their
abundance,
biocompatibility,
tailorable
properties,
and
environmental
responsiveness.
Realizing
full
potential
requires
understanding
the
molecular‐level
design
principles
that
govern
macroscopic
behavior.
This
review
analyzes
recent
advances
molecular
of
biopolymer‐based
hydrogels,
emphasizing
innovative
network
strategies
processing
methods
for
precise
control
over
material
properties
functions.
How
influences
hydrogel
behavior
across
multiple
length
scales
are
explored,
focusing
on:
1)
strategies:
approaches
like
double
networks,
interpenetrating
supramolecular
assemblies
tailor
mechanical
responsive
properties;
2)
techniques:
such
as
Hofmeister
effect‐induced
chain
aggregating,
cononsolvency‐based
porous
structure
controlling,
directional
freezing‐induced
alignment
achieve
hierarchical
anisotropic
structures.
these
influence
critical
strength,
inner
mass
transportation,
degradation
discussed.
The
also
covers
advanced
fabrication
techniques
leverage
create
complex,
functional
hydrogels.
By
elucidating
relationships
between
architecture,
methods,
resulting
this
work
aims
provide
a
framework
designing
next‐generation
with
enhanced
performance
functionality
various
applications.
Hydrogels
show
great
potential
in
biomedical
applications
due
to
their
inherent
biocompatibility,
high
water
content,
and
resemblance
the
extracellular
matrix.
However,
they
lack
self-powering
capabilities
often
necessitate
external
stimulation
initiate
cell
regenerative
processes.
In
contrast,
piezoelectric
materials
offer
but
tend
compromise
flexibility.
To
address
this,
creating
a
novel
hybrid
biomaterial
of
hydrogels
(PHs),
which
combines
advantageous
properties
both
materials,
offers
systematic
solution
challenges
faced
by
these
when
employed
separately.
Such
innovative
material
system
is
expected
broaden
horizons
applications,
such
as
piezocatalytic
medicinal
health
monitoring
showcasing
its
adaptability
endowing
with
properties.
Unique
functionalities,
like
enabling
self-powered
inducing
electrical
that
mimics
endogenous
bioelectricity,
can
be
achieved
while
retaining
hydrogel
matrix
advantages.
Given
limited
reported
literature
on
PHs,
here
recent
strategies
concerning
design
fabrication,
essential
properties,
distinctive
are
systematically
discussed.
The
review
concluded
providing
perspectives
remaining
future
outlook
for
PHs
field.
As
emerge
rising
star,
comprehensive
exploration
insights
into
new
biomaterials.
