ISO 10993-4 Compliant Hemocompatibility Evaluation of Gellan Gum Hybrid Hydrogels for Biomedical Applications DOI Creative Commons
Mthabisi Talent George Moyo, Terin Adalı, Oğuz Han Edebal

и другие.

Gels, Год журнала: 2024, Номер 10(12), С. 824 - 824

Опубликована: Дек. 13, 2024

This study examines the hemocompatibility of gellan-gum-based hybrid hydrogels, with varying gellan-gum concentrations and constant sodium alginate silk fibroin concentrations, respectively, in accordance ISO 10993-4 standards. While previous studies have focused on cytocompatibility, these hydrogels remains underexplored. Hydrogels were formulated 0.3%, 0.5%, 0.75%, 1% gellan gum combined 3% 4.2% separately, using physical ionic cross-linking. Swelling behavior was analyzed phosphate (pH 7.4) acetic 1.2) buffers surface morphology examined by scanning electron microscopy (SEM). Hemocompatibility tests included complete blood count (CBC), coagulation assays, hemolysis index, erythrocyte morphology, platelet adhesion analysis. Results showed that gum–sodium exhibited faster swelling than gum–silk formulations. SEM indicated smoother surfaces alginate, while increased roughness, further amplified higher concentrations. assays confirmed normal profiles formulations 0.75% gum, caused significant hemolytic thrombogenic activity. These findings highlight excellent especially variants, supporting their potential bioengineering, tissue engineering, blood-contacting biomedical applications.

Язык: Английский

Developing fibrin-based biomaterials/scaffolds in tissue engineering DOI Creative Commons
Songjie Li,

Xin Dan,

Han Chen

и другие.

Bioactive Materials, Год журнала: 2024, Номер 40, С. 597 - 623

Опубликована: Авг. 15, 2024

Tissue engineering technology has advanced rapidly in recent years, offering opportunities to construct biologically active tissues or organ substitutes repair even enhance the functions of diseased and organs. Tissue-engineered scaffolds rebuild extracellular microenvironment by mimicking matrix. Fibrin-based possess numerous advantages, including hemostasis, high biocompatibility, good degradability. Fibrin provide an initial matrix that facilitates cell migration, differentiation, proliferation, adhesion, also play a critical role cell-matrix interactions. are now widely recognized as key component tissue engineering, where they can facilitate defect repair. This review introduces properties fibrin, its composition, structure, biology. In addition, modification cross-linking modes fibrin discussed, along with various forms commonly used engineering. We describe biofunctionalization fibrin. provides detailed overview use applications skin, bone, nervous tissues, novel insights into future research directions for clinical treatment.

Язык: Английский

Процитировано

18

Polysaccharide-based hydrogels for medical devices, implants and tissue engineering: A review DOI

Dhruv Sanjanwala,

Vaishali Londhe, Rashmi Trivedi

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 256, С. 128488 - 128488

Опубликована: Дек. 2, 2023

Язык: Английский

Процитировано

23

Gellan Gum as a Unique Microbial Polysaccharide: Its Characteristics, Synthesis, and Current Application Trends DOI Creative Commons

Raghad Abdl Karim Abdl Aali,

Shayma Thyab Gddoa Al‐Sahlany

Gels, Год журнала: 2024, Номер 10(3), С. 183 - 183

Опубликована: Март 6, 2024

Gellan gum (GG) is a linear, negatively charged exopolysaccharide that biodegradable and non-toxic. When metallic ions are present, hard transparent gel produced, which remains stable at low pH. It exhibits high water solubility, can be easily bio-fabricated, demonstrates excellent film/hydrogel formation, biodegradable, shows biocompatibility. These characteristics render GG suitable option for use in food, biomedical, cosmetic fields. Thus, this review paper offers concise summary of microbial polysaccharides. Moreover, an in-depth investigation trends different facets GG, such as biosynthesis, chemical composition, physical properties, emphasized. In addition, highlights the process extracting purifying GG. Furthermore, discussion advantages disadvantages concerning other polysaccharides presented. utilization across industries, medicine, pharmaceuticals, cosmetics, etc., thoroughly examined will greatly benefit individuals involved field who seeking fresh opportunities innovative projects future.

Язык: Английский

Процитировано

14

Microscopic and Macroscopic Characterization of Hydrogels Based on Poly(vinyl-alcohol)–Glutaraldehyde Mixtures for Fricke Gel Dosimetry DOI Creative Commons
Silvia Locarno, Paolo Arosio,

Francesca Curtoni

и другие.

Gels, Год журнала: 2024, Номер 10(3), С. 172 - 172

Опубликована: Фев. 28, 2024

In recent decades, hydrogels have emerged as innovative soft materials with widespread applications in the medical and biomedical fields, including drug delivery, tissue engineering, gel dosimetry. this work, a comprehensive study of macroscopic microscopic properties hydrogel matrices based on Poly(vinyl-alcohol) (PVA) chemically crosslinked Glutaraldehyde (GTA) was reported. Five different kinds PVAs differing molecular weight degree hydrolysis were considered. The local organization studied through use

Язык: Английский

Процитировано

10

Conductive interpenetrating network organohydrogels of gellan gum/polypyrrole with weather-tolerance, piezoresistive sensing and shape-memory capability DOI
Panpan Li, Xinyu Jia,

Zhaolong Sun

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 262, С. 130215 - 130215

Опубликована: Фев. 15, 2024

Язык: Английский

Процитировано

9

Recent advances in scaffolding biomaterials for cultivated meat DOI

Samantha Fasciano,

Anas Wheba,

Christopher Ddamulira

и другие.

Biomaterials Advances, Год журнала: 2024, Номер 162, С. 213897 - 213897

Опубликована: Май 21, 2024

Язык: Английский

Процитировано

9

Food-packaging applications and mechanism of polysaccharides and polyphenols in multicomponent protein complex system: A review DOI
Jing Jiang,

Sheng Qian,

Tingyu Song

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132513 - 132513

Опубликована: Май 21, 2024

Язык: Английский

Процитировано

7

Challenges and opportunities in bioprocessing of gellan gum: A review DOI
Nageswar Sahu, Biswanath Mahanty, Dibyajyoti Haldar

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 276, С. 133912 - 133912

Опубликована: Июль 16, 2024

Язык: Английский

Процитировано

6

A review on polysaccharide-based tumor targeted drug nanodelivery systems DOI
Liangxing Tu,

Banghuai Xing,

Shenglin Ma

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140820 - 140820

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Excellent Cartilage Repair Performace Based on Pva/Pmpc-Cacl 2 Double-Network Hydrogel by Radiation Crosslinking Method DOI
X. Zhang, Kun Liu,

Shizhong Zhou

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0